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Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae
Open accessAbstract
In the yeast Saccharomyces cerevisiae , meiotic recombination is initiated by double-strand DNA breaks (DSBs). Meiotic DSBs occur at relatively high frequencies in some genomic regions (hotspots) and relatively low frequencies in others (coldspots). We used DNA microarrays to estimate variation in the level of nearby meiotic DSBs for all 6,200 yeast genes. Hotspots were nonrandomly associated with regions of high G + C base composition and certain transcriptional profiles. Coldspots were nonrandomly associated with the centromeres and telomeres.
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Cited by
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International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
Capturing Chromosome Conformation
Dekker, J., Rippe, K., Dekker, M., & Kleckner, N. (2002) · Science · doi:10.1126/science.1067799 · Cited by 3,652
Jeffreys, A. J., Kauppi, L., & Neumann, R. (2001) · Nature Genetics · doi:10.1038/ng1001-217 · Cited by 835
Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination
Myers, S., Bowden, R., Tumian, A., Bontrop, R. E., Freeman, C., MacFie, T. S., McVean, G., & Donnelly, P. (2010) · Science · doi:10.1126/science.1182363 · Cited by 683
Buck, M. J., & Lieb, J. D. (2004) · Genomics · doi:10.1016/j.ygeno.2003.11.004 · Cited by 608
Metadata
- Authors
- Gerton, J. L., DeRisi, J., Shroff, R., Lichten, M., Brown, P. O., & Petes, T. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-10-10
- Volume
- 97
- Issue
- 21
- Pages
- 11383-11390
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2071771941
- Cited by
- 480
- References
- 0
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Gerton, J. L., DeRisi, J., Shroff, R., Lichten, M., Brown, P. O., & Petes, T. D. (2000). Global mapping of meiotic recombination hotspots and coldspots in the yeast Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.21.11383
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