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A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides
Open accessAbstract
A blood clot is a meshwork of fibrin fibers built up by the systematic assembly of fibrinogen molecules proteolyzed by thrombin. Here, we describe a model of how the assembly process occurs. Five kinds of interaction are explicitly defined, including two different knob–hole interactions, an end-to-end association between γ-chains, a lateral association between γ-chains, and a hypothetical lateral interaction between β-chains. The last two of these interactions are responsible for protofibril association and are predicated on intermolecular packing arrangements observed in crystal structures of fibrin double-D fragments cocrystallized with synthetic peptides corresponding to the knobs exposed by the release of the fibrinopeptides A and B.
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Citations
Cited by
Fibrinogen and fibrin structure and functions
MOSESSON, M. W. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01365.x · Cited by 1,695
Weisel, J. W. (2005) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(05)70008-5 · Cited by 816
Fibrin Formation, Structure and Properties
Weisel, J. W., & Litvinov, R. I. (2017) · Subcellular Biochemistry · doi:10.1007/978-3-319-49674-0_13 · Cited by 729
Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics
Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.13 · Cited by 527
Undas, A., & Ariëns, R. A. S. (2011) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.230631 · Cited by 526
Metadata
- Authors
- Yang, Z., Mochalkin, I., & Doolittle, R. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-12-19
- Volume
- 97
- Issue
- 26
- Pages
- 14156-14161
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1972282939
- Cited by
- 200
- References
- 0
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- green
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- Yang, Z., Mochalkin, I., & Doolittle, R. F. (2000). A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.26.14156
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
