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Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10)
Open accessAbstract
We identified a viral IL-10 homolog encoded by an ORF (UL111a) within the human cytomegalovirus (CMV) genome, which we designated cmvIL-10. cmvIL-10 can bind to the human IL-10 receptor and can compete with human IL-10 for binding sites, despite the fact that these two proteins are only 27% identical. cmvIL-10 requires both subunits of the IL-10 receptor complex to induce signal transduction events and biological activities. The structure of the cmvIL-10 gene is unique by itself. The gene retained two of four introns of the IL-10 gene, but the length of the introns was reduced. We demonstrated that cmvIL-10 is expressed in CMV-infected cells. Thus, expression of cmvIL-10 extends the range of counter measures developed by CMV to circumvent detection and destruction by the host immune system.
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Metadata
- Authors
- Kotenko, S. V., Saccani, S., Izotova, L. S., Mirochnitchenko, O. V., & Pestka, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-02-15
- Volume
- 97
- Issue
- 4
- Pages
- 1695-1700
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2068665787
- Cited by
- 519
- References
- 0
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- green
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- Kotenko, S. V., Saccani, S., Izotova, L. S., Mirochnitchenko, O. V., & Pestka, S. (2000). Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.4.1695
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