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Cited by 613

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Mechanisms of use-dependent plasticity in the human motor cortex

Open access
Bütefisch, Cathrin M., Davis, Benjamin C., Wise, Steven P., Sawaki, Lumy, Kopylev, Leonid, Classen, Joseph, Cohen, Leonardo G.·2000·Proceedings of the National Academy of Sciences

Abstract

Practicing movements results in improvement in performance and in plasticity of the motor cortex. To identify the underlying mechanisms, we studied use-dependent plasticity in human subjects premedicated with drugs that influence synaptic plasticity. Use-dependent plasticity was reduced substantially by dextromethorphan (an N- methyl- d -aspartate receptor blocker) and by lorazepam [a γ-aminobutyric acid (GABA) type A receptor-positive allosteric modulator]. These results identify N -methyl- d -aspartate receptor activation and GABAergic inhibition as mechanisms operating in use-dependent plasticity in intact human motor cortex and point to similarities in the mechanisms underlying this form of plasticity and long-term potentiation.

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Crossref · 10.1073/pnas.97.7.3661

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Metadata

Authors
Bütefisch, C. M., Davis, B. C., Wise, S. P., Sawaki, L., Kopylev, L., Classen, J., & Cohen, L. G.
Venue
Proceedings of the National Academy of Sciences
Published
2000-03-14
Volume
97
Issue
7
Pages
3661-3665
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1977716670
Cited by
613
References
5
FWCI
7.60
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Mechanisms of use-dependent plasticity in the human motor cortex. https://app.cochat.ai/papers/10.1073/pnas.97.7.3661
The paper
Bütefisch, C. M., Davis, B. C., Wise, S. P., Sawaki, L., Kopylev, L., Classen, J., & Cohen, L. G. (2000). Mechanisms of use-dependent plasticity in the human motor cortex. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.7.3661

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.