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The molecular basis of vernalization: The central role of FLOWERING LOCUS C ( FLC )
Abstract
In Arabidopsis , the MADS-box protein encoded by FLOWERING LOCUS C ( FLC ) is a repressor of flowering. Vernalization, which promotes flowering in the late-flowering ecotypes and many late-flowering mutants, decreases the level of FLC transcript and protein in the plant. This vernalization-induced reduction in FLC transcript levels is mitotically stable and occurs in all tissues. FLC activity is restored in each generation, as is the requirement of a low-temperature exposure for the promotion of flowering. The level of FLC determines the extent of the vernalization response in the promotion of flowering, and there is a quantitative relationship between the duration of cold treatment and the extent of down-regulation of FLC activity. We conclude that FLC is the central regulator of the induction of flowering by vernalization. Other vernalization-responsive late-flowering mutants, which are disrupted in genes that encode regulators of FLC , are late-flowering as a consequence of their elevated levels of FLC .
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Cited by
Jaenisch, R., & Bird, A. (2003) · Nature Genetics · doi:10.1038/ng1089 · Cited by 6,325
EPIGENETIC VARIATION IN ASEXUALLY REPRODUCING ORGANISMS: SPECIAL SECTION
Verhoeven, K. J. F., & Preite, V. (2014) · Evolution · doi:10.1111/evo.12320 · Cited by 216
Metadata
- Authors
- Sheldon, C. C., Rouse, D. T., Finnegan, E. J., Peacock, W. J., & Dennis, E. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-03-14
- Volume
- 97
- Issue
- 7
- Pages
- 3753-3758
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W4235210785
- Cited by
- 604
- References
- 0
- FWCI
- 35.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sheldon, C. C., Rouse, D. T., Finnegan, E. J., Peacock, W. J., & Dennis, E. S. (2000). The molecular basis of vernalization: The central role of FLOWERING LOCUS C ( FLC ). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.7.3753
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