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Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives
Open accessAbstract
There has been much confusion recently about the relative merits of different approaches, osmotic stress, preferential interaction, and crowding, to describe the indirect effect of solutes on macromolecular conformations and reactions. To strengthen all interpretations of measurements and to forestall further unnecessary conceptual or linguistic confusion, we show here how the different perspectives all can be reconciled. Our approach is through the Gibbs-Duhem relation, the universal constraint on the number of ways it is possible to change the temperature, pressure, and chemical potentials of the several components in any thermodynamically defined system. From this general Gibbs-Duhem equation, it is possible to see the equivalence of the different perspectives and even to show the precise identity of the more specialized equations that the different approaches use.
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Minton, A. P. (1998) · Methods in Enzymology · doi:10.1016/s0076-6879(98)95038-8 · Cited by 317
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BISCHOF, J. C., & HE, X. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1363.003 · Cited by 351
Athawale, M. V., Dordick, J. S., & Garde, S. (2005) · Biophysical Journal · doi:10.1529/biophysj.104.056671 · Cited by 153
Schneck, E., Horinek, D., & Netz, R. R. (2013) · The Journal of Physical Chemistry B · doi:10.1021/jp400790f · Cited by 115
Metadata
- Authors
- Parsegian, V. A., Rand, R. P., & Rau, D. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-04-11
- Volume
- 97
- Issue
- 8
- Pages
- 3987-3992
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1970157213
- Cited by
- 490
- References
- 1
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Parsegian, V. A., Rand, R. P., & Rau, D. C. (2000). Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.97.8.3987
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