The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Platelet-mediated clumping of Plasmodium falciparum -infected erythrocytes is a common adhesive phenotype and is associated with severe malaria
Open accessAbstract
Sequestration of malaria-infected erythrocytes in the peripheral circulation has been associated with the virulence of Plasmodium falciparum . Defining the adhesive phenotypes of infected erythrocytes may therefore help us to understand how severe disease is caused and how to prevent or treat it. We have previously shown that malaria-infected erythrocytes may form apparent autoagglutinates of infected erythrocytes. Here we show that such autoagglutination of a laboratory line of P. falciparum is mediated by platelets and that the formation of clumps of infected erythrocytes and platelets requires expression of the platelet surface glycoprotein CD36. Platelet-dependent clumping is a distinct adhesive phenotype, expressed by some but not all CD36-binding parasite lines, and is common in field isolates of P. falciparum . Finally, we have established that platelet-mediated clumping is strongly associated with severe malaria. Precise definition of the molecular basis of this intriguing adhesive phenotype may help to elucidate the complex pathophysiology of malaria.
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Citations
Cites
Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta
Fried, M., & Duffy, P. E. (1996) · Science · doi:10.1126/science.272.5267.1502 · Cited by 1,108
Rapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
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Cited by
Genome sequence of the human malaria parasite Plasmodium falciparum
Gardner, M. J., Hall, N., Fung, E., White, O., Berriman, M., Hyman, R. W., Carlton, J. M., Pain, A., Nelson, K. E., Bowman, S., et al. (2002) · Nature · doi:10.1038/nature01097 · Cited by 4,407
Self-citationThe pathogenic basis of malaria
Miller, L. H., Baruch, D. I., Marsh, K., & Doumbo, O. K. (2002) · Nature · doi:10.1038/415673a · Cited by 1,746
Self-citationWhite, N. J., Pukrittayakamee, S., Hien, T. T., Faiz, M. A., Mokuolu, O. A., & Dondorp, A. M. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60024-0 · Cited by 1,123
The pathophysiology of vivax malaria
Anstey, N. M., Russell, B., Yeo, T. W., & Price, R. N. (2009) · Trends in Parasitology · doi:10.1016/j.pt.2009.02.003 · Cited by 428
Clinical features and pathogenesis of severe malaria
Mackintosh, C. L., Beeson, J. G., & Marsh, K. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.09.006 · Cited by 366
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Metadata
- Authors
- Pain, A., Ferguson, D. J. P., Kai, O., Urban, B. C., Lowe, B., Marsh, K., & Roberts, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-02-13
- Volume
- 98
- Issue
- 4
- Pages
- 1805-1810
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2073744746
- Cited by
- 303
- References
- 2
- FWCI
- 20.66
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Platelet-mediated clumping of Plasmodium falciparum -infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. https://app.cochat.ai/papers/10.1073/pnas.98.4.1805
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- Pain, A., Ferguson, D. J. P., Kai, O., Urban, B. C., Lowe, B., Marsh, K., & Roberts, D. J. (2001). Platelet-mediated clumping of Plasmodium falciparum -infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.4.1805
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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