The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain
Open accessAbstract
Signaling for cell death by Fas/APO1 occurs via a distinct region in its intracellular domain. This region contains a conserved sequence motif, the death domain motif, that is also found in the intracellular domains of the p55 tumor necrosis factor receptor and the low affinity nerve growth factor receptor, as well as in the regulatory domain of the ankyrins. A novel protein that specifically binds to the death domain of Fas/APO1 but not to Fas/APO1 molecules with a loss of function point mutation occurring in lprcg mice was cloned by a two-hybrid screen of a HeLa cells' cDNA library. The cloned protein itself contains a death domain motif, and this region binds to the death domain of Fas/APO1, while the region upstream to the death domain prompts self-association of the protein. Induced expression of the protein results in ligand-independent triggering of cytotoxicity, suggesting that it is involved in cell death induction by Fas/APO1.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the case of FAS and TRAILRs, the cognate ligands—namely, FAS ligand (FASLG; also known as CD95L or APO-1L) and TNF superfamily member 10 (TNFSF10; best known as TRAIL), respectively—stabilize preformed receptor homotrimers to induce a conformational change at their intracellular tails that enables the death domain (DD)-dependent association of the adapter Fas associated via death domain (FADD)”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [277]
Citations
Cites
A novel genetic system to detect protein–protein interactions
Fields, S., & Song, O.-K. (1989) · Nature · doi:10.1038/340245a0 · Cited by 6,152
Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.
Gossen, M., & Bujard, H. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5547 · Cited by 4,943
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153
Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716
Database of homology‐derived protein structures and the structural meaning of sequence alignment
Sander, C., & Schneider, R. (1991) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340090107 · Cited by 1,646
Yonehara, S., Ishii, A., & Yonehara, M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1747 · Cited by 1,398
A novel domain within the 55 kd TNF receptor signals cell death
Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290
Expression and structure of the human NGF receptor
Johnson, D., Lanahan, A. A., Buck, C. R., Sehgal, A., Morgan, C. J., Mercer, E., Bothwell, M. A., & Chao, M. V. (1986) · Cell · doi:10.1016/0092-8674(86)90619-7 · Cited by 963
Frangioni, J. V., & Neel, B. G. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1170 · Cited by 883
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
Itoh, N., & Nagata, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82075-0 · Cited by 845
Induction of Apoptosis by the Low-Affinity NGF Receptor
Rabizadeh, S., Oh, J. D., Zhong, L.-T., Yang, J., Bitler, C. M., Butcher, L. L., & Bredesen, D. E. (1993) · Science · doi:10.1126/science.8332899 · Cited by 775
Berger, J., Hauber, J., Hauber, R., Geiger, R. E., & Cullen, B. R. (1988) · Gene · doi:10.1016/0378-1119(88)90219-3 · Cited by 667
Engelmann, H., Novick, D., & Wallach, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)40049-5 · Cited by 547
Self-citationLux, S. E., John, K. M., & Bennett, V. (1990) · Nature · doi:10.1038/344036a0 · Cited by 522
Boldin, M., Mett, I. L., Varfolomeev, E. E., Chumakov, I., Shemer‐Avni, Y., Camonis, J., & Wallach, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.387 · Cited by 386
Self-citationAntibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.
Engelmann, H., Holtmann, H., Brakebusch, C., Avni, Y. S., SAROV, I., Nophar, Y., Hadas, E., Leitner, O., & Wallach, D. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77330-4 · Cited by 374
Self-citationCYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle, N., & Waksman, B. (1968) · Journal of Experimental Medicine · doi:10.1084/jem.128.6.1267 · Cited by 348
Lymphocyte Cytotoxicity in vitro: Activation and Release of a Cytotoxic Factor
Granger, G. A., & Williams, T. W. (1968) · Nature · doi:10.1038/2181253a0 · Cited by 264
Dicistronic transcription units for gene expression in mammalian cells
Dirks, W. G., Wirth, M., & Häuser, H. (1993) · Gene · doi:10.1016/0378-1119(93)90569-o · Cited by 176
Preparations of lymphotoxin induce resistance to their own cytotoxic effect.
Wallach, D. (1984) · The Journal of Immunology · doi:10.4049/jimmunol.132.5.2464 · Cited by 160
Self-citationBrakebusch, C., Nophar, Y., Kemper, O., Engelmann, H., & Wallach, D. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05133.x · Cited by 143
Self-citationDual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.
Bigda, J., Петрович, Б. И., Brakebusch, C., Varfolomeev, Y., Engelmann, H., Bigda, J., Holtmann, H., & Wallach, D. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.2.445 · Cited by 140
Self-citationRAMPAGE: Promoter Activity Profiling by Paired-End Sequencing of 5′-Complete cDNAs
Batut, P. J., & Gingeras, T. (2013) · Current Protocols in Molecular Biology · doi:10.1002/0471142727.mb25b11s104 · Cited by 79
From anemia to cerebellar dysfunction
LAMBERT, S., & Bennett, V. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb19863.x · Cited by 60
Song, H., Dunbar, J. D., & Donner, D. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31673-3 · Cited by 60
Wallach, D., Boldin, M., Varfolomeev, E. E., Bigda, Y., Camonis, J., & Mett, I. L. (1994) · Cytokine · doi:10.1016/1043-4666(94)90185-6 · Cited by 2
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,934
Caspases: the executioners of apoptosis
Cohen, G. M. (1997) · Biochemical Journal · doi:10.1042/bj3260001 · Cited by 4,737
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Two CD95 (APO‐1/Fas) signaling pathways
Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K., Krammer, P. H., & Peter, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1675 · Cited by 3,000
Metadata
- Authors
- Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., & Wallach, D.
- Affiliations
- Weizmann Institute of Science (IL)
- Inserm (FR)
- Corresponding author
- Wallach, David
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 270
- Issue
- 14
- Pages
- 7795-7798
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1968328677
- Cited by
- 993
- References
- 27
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 15 · 2018: 17 · 2017: 11 · 2016: 8 · 2015: 6 · 2014: 10 · 2013: 15 · 2012: 10
- FWCI
- 34.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- death domain, death receptor signaling, apoptosis, protein-protein interaction, p75 neurotrophin receptor, lpr mice, two-hybrid screen, protein self-association
- MeSH terms
- Amino Acid Sequence, Animals, Antigens, Surface, Carrier Proteins, Cloning, Molecular, HeLa Cells, Humans, Molecular Sequence Data, Proteins, Apoptosis, Sequence Homology, Amino Acid, DNA, Complementary, fas Receptor, Adaptor Proteins, Signal Transducing, Mice, Fas-Associated Death Domain Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
