The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
SH3 Domain-mediated Interaction of Dystroglycan and Grb2
Open accessAbstract
Dystroglycan is a novel laminin receptor that links the extracellular matrix and sarcolemma in skeletal muscle. The dystroglycan complex containing alpha- and beta-dystroglycan also serves as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. beta-Dystroglycan has now been expressed in vitro and shown to directly interact with Grb2, an adapter protein involved in signal transduction and cytoskeletal organization. Protein binding assays with two Grb2 mutants, Grb2/P49L and Grb2/G203R, which correspond to the loss-of-function mutants in the Caenorhabditis elegans sem-5, demonstrated that the dystroglycan-Grb2 association is through beta-dystroglycan C-terminal proline-rich domains and Grb2 Src homology 3 domains. Affinity chromatography has also shown endogenous skeletal muscle Grb2 interacts with beta-dystroglycan. Immunoprecipitation experiments have demonstrated that Grb2 associates with alpha/beta-dystroglycan in vivo in both skeletal muscle and brain. The specific dystroglycan-Grb2 interaction may play an important role in extracellular matrix-mediated signal transduction and/or cytoskeleton organization in skeletal muscle that may be essential for muscle cell viability.
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Cites
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Cited by
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Self-citationRole for α-dystrobrevin in the pathogenesis of dystrophin-dependent muscular dystrophies
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ADHESION MOLECULES AND INHERITED DISEASES OF THE HUMAN NERVOUS SYSTEM
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Metadata
- Authors
- Yang, B., Jung, D., Motto, D., Meyer, J., Koretzky, G., & Campbell, K. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 270
- Issue
- 20
- Pages
- 11711-11714
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1995635449
- Cited by
- 254
- References
- 30
- FWCI
- 5.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Yang, B., Jung, D., Motto, D., Meyer, J., Koretzky, G., & Campbell, K. P. (1995). SH3 Domain-mediated Interaction of Dystroglycan and Grb2. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.20.11711
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
