Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger
Open accessAbstract
Research into phospholipid signaling continues to flourish, as more and more bioactive lipids are being identified and their actions characterized. One interesting addition to the growing list of lipid messengers is lysophosphatidic acid (LPA1(1) ; 1-acyl-glycerol-3-phosphate), the simplest of all glycerophospholipids. While LPA has long been known as a precursor of phospholipid biosynthesis in both eukaryotic and prokaryotic cells, only recently has LPA emerged as an intercellular signaling molecule that is rapidly produced and released by activated cells, notably platelets, to influence target cells by acting on a specific cell-surface receptor (1).
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Serum factors such as lysophosphatidic acid use alternative intermediates to activate RhoA.
“However, GEF-H1 knockout cells could still trigger RhoA in response to serum addition, indicating that serum factors such as lysophosphatidic acid 44 use alternative intermediates to activate RhoA.”
From Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling (2026) · cites this paper as [44]
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Research works printed but not linked: 5
- Tigyi, G., Dyer, D. L., and Miledi, R (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1908-1912
- Jalink, K, Moolenaar, W. H., and van Duijn, B. (1993) Proc. Natl. Acad. Sci.
- Van Corven, E. J., Hordijk, P. L., Medema, R H., Bos, J. L., and Moolenaar, W. H. (1993) Proc. Nat!. Acad. Sci. U. S. A. 90, 1257-1261
- Koch, W. J., Hawes, B. E., Allen, L. F., and Lefkowitz, R J. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12706-12710
- Roche, S., Koegl, M., and Courtneidge, S. A (1994) Proc. Natl. Acad. Sci.
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Athenstaedt, K., & Daum, G. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00822.x · Cited by 403 · see citing works
PCSK9 deficiency alters brain lipid composition without affecting brain development and function
Pärn, A., Olsen, D., Tuvikene, J., Kaas, M., Borisova, E., Bilgin, M., Elhauge, M., Vilstrup, J., Madsen, P., Ambrozkiewicz, M. C., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1084633 · Cited by 16 · see citing works
Meiring, J. C. M., Mahapatra, V., Liu, R., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Pelster José, A., Karhanova, A., Metallidou, I., et al. (2026) · Nature Cell Biology · doi:10.1038/s41556-026-02079-4
- Authors
- Moolenaar, W. H.
- Affiliations
- The Netherlands Cancer Institute (NL)
- Corresponding author
- Moolenaar, Wouter H.
- ORCID
- Moolenaar, Wouter H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 270
- Issue
- 22
- Pages
- 12949-12952
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2092869660
- Cited by
- 584
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 11 · 2012: 14
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- lysophosphatidic acid, lipid signaling, bioactive lipids, glycerophospholipids, platelet activation, LPA1 receptor, intercellular communication, phospholipid synthesis
- MeSH terms
- Animals, Lysophospholipids, Phospholipids, Structure-Activity Relationship, Signal Transduction, GTP-Binding Proteins
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