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Delayed Mammary Tumor Progression in Muc-1 Null Mice
Open accessAbstract
The mucin gene, Muc-1, encodes a high molecular weight integral membrane glycoprotein that is present on the apical surface of most simple secretory epithelial cells. Muc-1 is highly expressed and aberrantly glycosylated by most carcinomas and metastatic lesions. Numerous functions have been proposed for this molecule, including protection of the epithelial cell surface, an involvement in epithelial organogenesis, and a role in tumor progression. Mice deficient in Muc-1 were generated using homologous recombination in embryonic stem cells. These mice appeared to develop normally and were healthy and fertile. However, the growth rate of primary breast tumors induced by polyoma middle T antigen was found to be significantly slower in Muc-1 deficient mice. This suggests that Muc-1 plays an important role in the progression of mammary carcinoma.
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Cited by
Camenisch, T. D., Spicer, A. P., Brehm-Gibson, T., Biesterfeldt, J., Augustine, M. L., Calabro, A., Kubalak, S., Klewer, S. E., & McDonald, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10272 · Cited by 901
Self-citationTerminal Differentiation of Human Breast Cancer through PPARγ
Mueller, E., Sarraf, P., Tontonoz, P., Evans, R. M., Martin, K. J., Zhang, M., Fletcher, C., Singer, S., & Spiegelman, B. M. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80047-7 · Cited by 851
MUC1 cell surface mucin is a critical element of the mucosal barrier to infection
McAuley, J. L., Linden, S. K., Png, C. W., King, R. M., Pennington, H. L., Gendler, S. J., Florin, T. H., Hill, G. R., Korolik, V., & McGuckin, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci26705 · Cited by 438
Self-citationOrigin and Secretion of Milk Lipids
Mather, I. H., & Keenan, T. W. (1998) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/a:1018711410270 · Cited by 360
Kirby, A., Gnirke, A., Jaffe, D. B., Barešová, V., Pochet, N., Blumenstiel, B., Ye, C., Aird, D., Stevens, C., Robinson, J. T., et al. (2013) · Nature Genetics · doi:10.1038/ng.2543 · Cited by 306
Metadata
- Authors
- Spicer, A. P., Rowse, G. J., Lidner, T. K., & Gendler, S. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 270
- Issue
- 50
- Pages
- 30093-30101
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2027233329
- Cited by
- 266
- References
- 0
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Spicer, A. P., Rowse, G. J., Lidner, T. K., & Gendler, S. J. (1995). Delayed Mammary Tumor Progression in Muc-1 Null Mice. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.50.30093
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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