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Cloning and Functional Expression of Rat CLC-5, a Chloride Channel Related to Kidney Disease
Open accessAbstract
We have cloned a novel member of the CLC chloride channel family from rat brain, rCLC-5. The cDNA predicts a 83-kDa protein belonging to the branch including CLC-3 and CLC-4, with which it shares approximately 80% identity. Expression of rCLC-5 in Xenopus oocytes elicits novel anion currents. They are strongly outwardly rectifying and have a conductivity sequence of NO3- > Cl- > Br- > I- >> glutamate-. Although CLC-5 has consensus sites for phosphorylation by protein kinase A, raising the intracellular cAMP concentration had no effect on these currents. Currents were also unchanged when rCLC-5 was coexpressed with rCLC-3 and rCLC-4, either singly or in combination. rCLC-5 is expressed predominantly in kidney and also in brain, lung, and liver. Along the nephron, rCLC-5 message is detectable in all tubule segments investigated, but expression in the glomerulus and the S2 segment of the proximal tubule is low.
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Cited by
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Self-citationStobrawa, S. M., Breiderhoff, T., Takamori, S., Engel, D., Schweizer, M., Zdebik, A. A., Bösl, M. R., Ruether, K., Jahn, H., Draguhn, A., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00189-1 · Cited by 508
Self-citationStructure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle
Feng, L., Campbell, E. B., Hsiung, Y., & MacKinnon, R. (2010) · Science · doi:10.1126/science.1195230 · Cited by 270
Metadata
- Authors
- Steinmeyer, K., Schwappach, B., Bens, M., Vandewalle, A., & Jentsch, T. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 270
- Issue
- 52
- Pages
- 31172-31177
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2122901539
- Cited by
- 282
- References
- 0
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Steinmeyer, K., Schwappach, B., Bens, M., Vandewalle, A., & Jentsch, T. J. (1995). Cloning and Functional Expression of Rat CLC-5, a Chloride Channel Related to Kidney Disease. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.52.31172
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