Cited by 647Inflammatory mediators and NSAID effectsNF-κB Signaling PathwaysSignaling Pathways in Disease

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells.

Open access

Yamamoto, Kei, Arakawa, Toshiya, Ueda, Natsuo, Yamamoto, Shozo·1995·Journal of Biological Chemistry

Open this paper in CoChat — free account Open PDF

Abstract

When a mouse osteoblastic cell line MC3T3-E1 was cultured in the presence of tumor necrosis factor alpha (TNF alpha), the release of prostaglandin E2 and the cyclooxygenase activity increased in a dose- and time-dependent manner. The increase of the enzyme activity was attributed mostly to the induction of cyclooxygenase-2 rather than cyclooxygenase-1 as judged by the inhibitory effect of NS398, Western blotting, and Northern blotting. In this system we attempted to elucidate the transcriptional regulation of the cyclooxygenase-2 gene. As examined by the luciferase assay, two positive regulatory regions (-186 to -131 and -512 to -385 base pairs) were found in the 5'-flanking promoter region of the mouse cyclooxygenase-2 gene in the TNF alpha-stimulated cells. The former included putative NF-IL6 (C/EBP beta) and AP2 elements, and the latter contained the NF kappa B motif. A DNA probe including the NF-IL6 and AP2 sites gave positive bands upon electrophoretic mobility shift assay using the nuclear extracts of MC3T3-E1 cells. The bands were supershifted by the addition of anti-NF-IL6 antibody but not by anti-AP2 antibody. A probe including the NF kappa B site also gave positive bands, which were supershifted by anti-NF kappa B p50 and p65 antibodies. Furthermore, when the motif of NF-IL6 or NF kappa B or both was subjected to point mutation, the luciferase activity was markedly reduced. These data suggested a potential role of both NF-IL6 and NF kappa B in the induction of cyclooxygenase-2 by TNF alpha.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1074/jbc.270.52.31315

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O. H., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 316,394
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
Sen, R., & Baltimore, D. (1986) · Cell · doi:10.1016/0092-8674(86)90346-6 · Cited by 2,754
In vitro differentiation and calcification in a new clonal osteogenic cell line derived from newborn mouse calvaria.
Sudo, H., Kodama, H. A., Amagai, Y., Yamamoto, S., & Kasai, S. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.1.191 · Cited by 1,673
NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control
Lenardo, M. J., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90833-7 · Cited by 1,542
A nuclear factor for IL‐6 expression (NF‐IL6) is a member of a C/EBP family.
Akira, S., Isshiki, H., Sugita, T., Tanabe, O., Kinoshita, S. M., Nishio, Y., Nakajima, T., Hirano, T., & Kishimoto, T. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08316.x · Cited by 1,450
The inducible transcription activator NF-κB: regulation by distinct protein subunits
Baeuerle, P. A. (1991) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(91)90007-8 · Cited by 1,025
Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
Matsusaka, T., Fujikawa, K., Nishio, Y., Mukaida, N., Matsushima, K., Kishimoto, T., & Akira, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10193 · Cited by 959
Compilation of vertebrate-encoded transcription factors
Faisst, S., & Meyer, S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.1.3 · Cited by 902
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., & Otomo, S. (1994) · Prostaglandins · doi:10.1016/0090-6980(94)90074-4 · Cited by 821
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
Wiegmann, K., Schütze, S., Machleidt, T., Witte, D., & Krönke, M. (1994) · Cell · doi:10.1016/0092-8674(94)90275-5 · Cited by 714

Flagged first, then by citations

Show all 38 references

Research works printed but not linked: 4

Xie, 1994, Mol. Cell. Biol., 14, 6531
Kusaka, 1988, Biochim. Biophys. Acta, 972, 339
Isshiki, 1990, Mol. Cell. Biol., 10, 2757
Baeuerle, 1991, Biochim. Biophys. Acta, 1072, 63

Sorted by citations

Items 401–500 of 645

Dietary Cameroonian Plants Exhibit Anti-Inflammatory Activity in Human Gastric Epithelial Cells
Nwakiban, A. P. A., Fumagalli, M., Piazza, S., Magnavacca, A., Martinelli, G., Beretta, G., Magni, P., Tchamgoue, A. D., Agbor, G. A., Kuiate, J., et al. (2020) · Nutrients · doi:10.3390/nu12123787 · Cited by 34
Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide
Kobayashi, M., Watanabe, K., Yokoyama, S., Matsumoto, C., Hirata, M., Tominari, T., Inada, M., & Miyaura, C. (2012) · ISRN Pharmacology · doi:10.5402/2012/439860 · Cited by 34
Translationally regulated C/EBPβ isoform expression upregulates metastatic genes in hormone‐independent prostate cancer cells
Kim, M. H., & Field, J. (2008) · The Prostate · doi:10.1002/pros.20801 · Cited by 34
Interleukin-1β and dexamethasone regulate gene expression of prostaglandin H synthase-2 via the NF-kB pathway in human amnion derived WISH cells
Wang, Z., & Tai, H. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90053-9 · Cited by 34
Expression of cyclooxygenase-2 in rat vascular smooth muscle cells is unrelated to nuclear factor-κB activation
Chen, G., Wood, E. G., Wang, S. H., & Warner, T. D. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00055-7 · Cited by 33
NF-?B-dependent gene expression of proinflammatory cytokines in T24 cells: possible role in interstitial cystitis
Abdel‐Mageed, A. B. (2003) · Urological Research · doi:10.1007/s00240-003-0339-9 · Cited by 33
“Cyclooxygenase-2, another inducible enzyme regulated by NFjB [ 26 ], is responsible for the increased production of prostaglandin and thromboxane in inflammatory diseases [9].”
Background
Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve
Hu, W. W., Mathey, E. K., Hartung, H., & Kieseier, B. C. (2003) · Neurology · doi:10.1212/01.wnl.0000098884.75756.4d · Cited by 33
C/EBPβ regulates metastatic gene expression and confers TNF‐α resistance to prostate cancer cells
Kim, M. H., Minton, A. Z., & Agrawal, V. (2009) · The Prostate · doi:10.1002/pros.20993 · Cited by 33
Cyclolinteinone, a sesterterpene from sponge Cacospongia linteiformis, prevents inducible nitric oxide synthase and inducible cyclo-oxygenase protein expression by blocking nuclear factor-κB activation in J774 macrophages
D’Acquisto, F., Lanzotti, V., & Carnuccio, R. (2000) · Biochemical Journal · doi:10.1042/bj3460793 · Cited by 36
Cross-linking of the high-affinity IgE receptor induces the expression of cyclo-oxygenase 2 and attendant prostaglandin generation requiring interleukin 10 and interleukin 1β in mouse cultured mast cells
ASHRAF, M., Murakami, M., & Kudo, I. (1996) · Biochemical Journal · doi:10.1042/bj3200965 · Cited by 33
Cyclooxygenase-2 Expression, Prostacyclin Production and Endothelial Protection of High-density Lipoprotein
Liu, D., Liang, J., Wang, Y., & Zheng, L. (2012) · Cardiovascular & Haematological Disorders - Drug Targets · doi:10.2174/1871529x11202020098 · Cited by 33
“activation [77, 78].”
Modulation of Ovarian Structure and Abdominal Obesity in Curcumin- and Flutamide-treated Aging FSH-R Haploinsufficient Mice
Tiwari-Pandey, R., & Sairam, M. R. (2009) · Reproductive Sciences · doi:10.1177/1933719109332822 · Cited by 32
Risk Assessment of Tetrabromobisphenol a on Cyclooxygenase-2 Expression Via Map Kinase/NF-κB/AP-1 Signaling Pathways in Murine Macrophages
Han, E. H., Park, J. H., Kang, K. W., Jeong, T. C., Kim, H. S., & Jeong, H. G. (2009) · Journal of Toxicology and Environmental Health · doi:10.1080/15287390903212873 · Cited by 32
“To date, NF-kB, AP-1, NF-IL6, CRE, and the E-box transcriptional elements were reported to be involved in COX-2 expression (Yamamoto et al., 1995; Guo et al., 2001; Zhou et al., 2003).”
Background
Nuclear Factor- B p50 Is Required for Tumor Necrosis Factor- -Induced Colony-Stimulating Factor-1 Gene Expression in Osteoblasts
Yao, G., Sun, B., Insogna, K. L., & Weir, E. C. (2000) · Endocrinology · doi:10.1210/endo.141.8.7592 · Cited by 34
Hypertonic induction of COX-2 expression in renal medullary epithelial cells requires transactivation of the EGFR
Zhao, H., Tian, W., Tai, C., & Cohen, D. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00030.2003 · Cited by 32
Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38 mitogen-activated protein kinase and cytoplasmic shuttling of HuR
Jin, S. H., Kim, T. I., Yang, K. M., & Kim, W. H. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.060 · Cited by 32
Ginsenoside Rg1 protects against hind-limb ischemia reperfusion induced lung injury via NF-κB/COX-2 signaling pathway
Ye, Y., Shan, Y., Bao, C.-Y., Hu, Y., & Wang, L. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.04.040 · Cited by 31
The Involvement of NFAT Transcriptional Activity Suppression in SIRT1-Mediated Inhibition of COX-2 Expression Induced by PMA/Ionomycin
Jia, Y., Lu, J., Huang, Y., Liu, G., Gao, P., Wan, Y.-Z., Zhang, R., Zhang, Z., Yang, R., Tang, X., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097999 · Cited by 31
“In addition, a NF-kB binding site also exists in human COX-2 promoter region: 59GGGATTCCC-39 (2447 to 2439 bp) [27,28].”
Background
An Asp49 Phospholipase A2from Snake Venom Induces Cyclooxygenase-2 Expression and Prostaglandin E2Production via Activation of NF-κB, p38MAPK, and PKC in Macrophages
Moreira, V., Lomonte, B., Vinolo, M. A. R., Curi, R., Gutiérrez, J. M., & Teixeira, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/105879 · Cited by 31
15-Deoxy-Δ12,14-prostaglandin J2 induces Cox-2 expression in human osteosarcoma cells through MAPK and EGFR activation involving reactive oxygen species
Kitz, K., Windischhofer, W., Leis, H., Huber, E., Kollroser, M., & Malle, E. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.12.039 · Cited by 31
“NF-κBmediated activation might be involved in Cox-2 expression [56–58],”
Background
MicroRNA Involved in Inflammation: Control of Eicosanoid Pathway
Ochs, M. J., Steinhilber, D., & Suess, B. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00039 · Cited by 31
“Numerous transcription factors such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), or cAMP-responsive element binding protein (CREP) are involved in the transcriptional regulation (Yamamoto et al., 1995; Kang et al., 2007).”
Background
RNAi-Based Strategies for Cyclooxygenase-2 Inhibition in Cancer
Strillacci, A., Griffoni, C., Valerii, M. C., Lazzarini, G., Tomasi, V., & Spisni, E. (2010) · BioMed Research International · doi:10.1155/2010/828045 · Cited by 31
Localization of cyclooxygenase-2 induced following traumatic spinal cord injury
Adachi, K., Yimin, Y., Satake, K., Matsuyama, Y., Ishiguro, N., Sawada, M., Hirata, Y., & Kiuchi, K. (2004) · Neuroscience Research · doi:10.1016/j.neures.2004.10.007 · Cited by 31
“Nuclear factor-kB (NF-kB) responsive elements are known to exist in the promoter region of the COX-2 gene (Yamamoto et al., 1995; Jobin et al., 1998) as well as in iNOS (Chao et al.”
Background
Effects of NSAIDs on the kidney
Murray, M. D., & Brater, D. C. (1997) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8863-9_5 · Cited by 31
Zyflamend, a Polyherbal Preparation, Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis Through Down-Regulation of NF-κ B Activation and NF-κ B–Regulated Gene Products
Sandur, S. K., Ahn, K. S., Ichikawa, H., Sethi, G., Shishodia, S., Newman, R. A., & Aggarwal, B. B. (2007) · Nutrition and Cancer · doi:10.1080/01635580701268295 · Cited by 30
Ephedorae herba Decreases Lipopolysaccharide-Induced Cyclooxgenase-2 Protein Expression and NF-κB-Dependent Transcription in C6 Rat Glioma Cells
Aoki, K., Yamakuni, T., Yoshida, M., & Ohizumi, Y. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.sc0050118 · Cited by 30
Effect of nonsteroidal anti-inflammatory drugs on the gastrointestinal tract: diagnosis by wireless capsule endoscopy
Chutkan, R. K., & Toubia, N. A. (2004) · Gastrointestinal Endoscopy Clinics of North America · doi:10.1016/j.giec.2003.10.009 · Cited by 30
Involvement of CCAAT Enhancer Binding Protein Transcription Factors in the Regulation of Prostaglandin G/H Synthase 2 Expression by Interleukin-1 in Osteoblastic MC3T3-E1 Cells
Harrison, J. R., Kelly, P. L., & Pilbeam, C. C. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.6.1138 · Cited by 30
“(25) reported that the C/EBP site as well as an NFkB site located at 2401/2393 bp are required for maximal PGHS-2 responsiveness to TNFa.”
Background
Tanshinone IIA attenuates Aβ-induced neurotoxicity by down-regulating COX-2 expression and PGE2 synthesis via inactivation of NF-κB pathway in SH-SY5Y cells
Geng, L., Liu, W., & Chen, Y. (2019) · Journal of Biological Research - Thessaloniki · doi:10.1186/s40709-019-0102-1 · Cited by 29
Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
Ahmad, B., Gamallat, Y., Khan, M. F., Din, S. R. U., Israr, M., Ahmad, M., Tahir, N., Azam, N., Rahman, K. U., Wang, X., et al. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s287354 · Cited by 30
Cyclooxygenase-2 and n-6 PUFA are lower and DHA is higher in the cortex of fat-1 mice
Boudrault, C., Bazinet, R. P., Kang, J. X., & David, W. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2009.12.022 · Cited by 29
Behavioral suppression induced by cannabinoids is due to activation of the arachidonic acid cascade in rats
Yamaguchi, T., Shoyama, Y., Watanabe, S., & Yamamoto, T. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03127-9 · Cited by 29
Regulation of nuclear factor‐κB in intestinal epithelial cells in a cell model of inflammation
Homaidan, F. R., Chakroun, I., & El-Sabban, M. E. (2003) · Mediators of Inflammation · doi:10.1080/09629350310001619681 · Cited by 29
Signaling Pathways for Tnfa-Induced Cox-2 Expression: Mediation Through Map Kinases And Nfkb, And Inhibition By Certain Nonsteroidal Anti-Inflammatory Drugs
Paik, J., Lee, J. Y., & Hwang, D. H. (2002) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0193-0_77 · Cited by 29
Ischemic tolerance in the brain
Kapinya, K. J. (2005) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.92.2005.1.9 · Cited by 28
Nitric oxide stimulates cyclooxygenase-2 in cultured cTAL cells through a p38-dependent pathway
Cheng, H., Zhang, M., & Harris, R. C. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00315.2005 · Cited by 28
Nitric oxide prevents inducible cyclooxygenase expression by inhibiting nuclear factor-κB and nuclear factor-interleukin-6 activation
D’Acquisto, F., Maiuri, M. C., de Cristofaro, F., & Carnuccio, R. (2001) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100100435 · Cited by 28
“Yamamoto et al. (1995) were used as probes:”
Influential
Complement C5b-9 induces cyclooxygenase-2 gene transcription in glomerular epithelial cells
Takano, T., Cybulsky, A. V., Yang, X., & Aoudjit, L. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.0048.2001 · Cited by 28
Anti-inflammatory and anti-catabolic effects of TENDOACTIVE® on human tenocytes in vitro.
Shakibaei, M., Buhrmann, C., & Mobasheri, A. (2011) · PubMed · doi:10.14670/hh-26.1173 · Cited by 27
Contribution of a Nuclear Factor-κB Binding Site to Human Angiotensinogen Promoter Activity in Renal Proximal Tubular Cells
Acres, O. W., Satou, R., Navar, L. G., & Kobori, H. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.165464 · Cited by 27
Combination chemoprevention
Zhou, P., Cheng, S., Yang, R. H., Wang, B., & Liu, J. (2012) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e32834dbbfd · Cited by 27
Saponin fraction isolated from Conyza blinii H.Lév. demonstrates strong anti-cancer activity that is due to its NF-κB inhibition
Ma, L., Liu, H., Qin, P., Hu, C., Man, S., Li, Y., Liu, Z., Liu, Z., & Diao, A. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.066 · Cited by 27
COX-2 inhibition results in alterations in nuclear factor (NF)-κB activation but not cytokine production in acute pancreatitis
Slogoff, M. I., Ethridge, R. T., Rajaraman, S., & Evers, B. M. (2004) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2003.11.023 · Cited by 27
Cytosolic phospholipase A2 and the distinct transcriptional programs of astrocytoma cells
Hernández, M., Nieto, M. L., & Crespo, M. S. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01563-0 · Cited by 27
Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF
Aggarwal, S., Takada, Y., Mhashilkar, A. M., Sieger, K., Chada, S., & Aggarwal, B. B. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4368 · Cited by 27
DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site
Crawley, C. D., Raleigh, D. R., Kang, S., Voce, D. J., Schmitt, A. M., Weichselbaum, R. R., & Yamini, B. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1120 · Cited by 27
RETRACTED: Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway
Park, B., Sung, B., Yadav, V. R., Chaturvedi, M. M., & Aggarwal, B. B. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.062 · Cited by 26
Retracted
Coenzyme Q10 attenuated β-amyloid25–35–induced inflammatory responses in PC12 cells through regulation of the NF–κB signaling pathway
Li, L., Xu, D., Lin, J., Zhang, D., Wang, G.-H., Sui, L., Ding, H., & Du, J. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.04.014 · Cited by 26
“A number of studies suggest that NF–κB activation and binding to the Cox–2 promoter region are required for inducing COX–2 expression (Yamamoto et al.1995; Hwang et al. 1997).”
Background
Suppression of the NF‑κB signaling pathway in colon cancer cells by the natural compound Riccardin D from Dumortierahirsute
Liu, H., Li, G., Zhang, B., Sun, D., Wu, J., Chen, F., Kong, F., Luan, Y., Jiang, W., Wang, R., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8617 · Cited by 26
Extracellular HIV-Tat Induces Cyclooxygenase-2 in Glial Cells through Activation of Nuclear Factor of Activated T Cells
Blanco, A., Álvarez, S., Fresno, M., & Muñoz‐Fernández, M. Á. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.530 · Cited by 26
“For example, in macrophages NF- B (36), NF-IL6/CCAAT enhancer-binding protein (37), and cAMP response element-binding proteins are required for COX-2 transcriptional induction in response to variety of stimuli.”
Background
Enhanced secretion of prostaglandin E2 from osteoblasts by exposure to a strong static magnetic field
Sakurai, T., Terashima, S., & Miyakoshi, J. (2007) · Bioelectromagnetics · doi:10.1002/bem.20392 · Cited by 26
“…field in a Tesla (1 Tesla (T)¼ 10,000 Gauss)-order strong SMF, which is not observed under exposure to weak magnetic fields [Torbet and Dickens, 1984; Ueno et al., 1993; Iwasaka et al., 1994; Yamamoto et al., 1995; Kotani et al., 2000; Hirose et al., 2003a; Iwasaka and Ueno, 2005; Miyakoshi, 2005].”
Background
Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes
Jiménez, J. L., Iñiguez, M. A., Muñoz‐Fernández, M. Á., & Fresno, M. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.002 · Cited by 26
Induction of Cyclooxygenase‐2 by Overexpression of the Human Catalase Gene in Cerebral Microvascular Endothelial Cells
Fang, X., Moore, S. A., Nwankwo, O. J., Weintraub, N. L., Oberley, W. L., Snyder, D. G., & Spector, A. A. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0750614.x · Cited by 26
“Substances that affect COX-2 gene transcription include nuclear factorkB, cyclic AMP response element, nuclear factor IL-6, peroxisome proliferators, and activator factor-1 (Inoue et al., 1995; Yamamoto et al., 1995; Xie and Herschman, 1996; Dean et al., 1999; Meade et al., 1999).”
Background
Cyclooxygenase-2 downregulates inducible nitric oxide synthase in rat intestinal epithelial cells
Kobayashi, O., Miwa, H., Watanabe, S., Tsujii, M., DuBois, R. N., & Sato, N. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.3.g688 · Cited by 26
Signaling Mechanisms of Endogenous Angiogenesis Inhibitors Derived from Type IV Collagen
Sudhakar, A., & Boosani, C. S. (2007) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s345 · Cited by 25
“NFκB may facilitate the induction of COX-2 by lipopolysaccharide and phorbol ester in concert with the nuclear factorinterleukin-6 expression site and a cAMP responsive element site in bovine aortic endothelial cells (Inoue et al. 1995; Yamamoto et al. 1995).”
Background
Modulation by gamithromycin and ketoprofen of in vitro and in vivo porcine lipopolysaccharide-induced inflammation
Wyns, H., Meyer, E., Plessers, E., Watteyn, A., van Bergen, T., Schauvliege, S., Baere, S. D., Devreese, M., Backer, P. D., & Croubels, S. (2015) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2015.09.014 · Cited by 25
Proinflammatory and Proadhesive Activation of Lymphocytes and Macrophages in Sudden Sensorineural Hearing Loss
Kassner, S. S., Schoettler, S., Bonaterra, G. A., Stern-Sträter, J., Sommer, U. J., Hörmann, K., Kinscherf, R., & Gössler, U. R. (2010) · Audiology and Neurotology · doi:10.1159/000320610 · Cited by 25
“CD40 belongs to the TNF- superfamily inducing nuclear factor- B (NFB) that induces inflammatory enzymes like COX-2 [Yamamoto et al., 1995].”
Background
Transcription factor NF-κB (p50/p50, p65/p65) controls porcine ovarian cells functions
Pavlová, S., Klucska, K., Vašíček, D., Kotwica, J., & Sirotkin, A. V. (2011) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2011.09.005 · Cited by 25
Activation of NF‐κB in human osteoblasts by stimulators of bone resorption
Ali, N. N., Gilston, V., & Winyard, P. G. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01370-8 · Cited by 25
Angiotensin II Activates the Calcineurin/NFAT Signaling Pathway and Induces Cyclooxygenase-2 Expression in Rat Endometrial Stromal Cells
Abraham, F., Sacerdoti, F., León, R. D., Gentile, T., & Canellada, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037750 · Cited by 24
“These sequences have been shown to act as positive regulatory elements for the Cox-2 gene transcription in various cell types [47–50].”
Selective cyclooxygenase-2 inhibitor ameliorates cholecystokinin-octapeptide-induced acute pancreatitis in rats
Seo, S.-W. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i16.2298 · Cited by 25
Protein kinase C‐ε mediates bradykinin‐induced cyclooxygenase‐2 expression in human airway smooth muscle cells
Pang, L., Nie, M., Corbett, L. M., Donnelly, R., Gray, S., & Knox, A. J. (2002) · The FASEB Journal · doi:10.1096/fj.02-0169fje · Cited by 25
Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate
Nguyen, L. K., Cavadas, M. A. S., Kholodenko, B. Ν., Frank, T. D., & Cheong, A. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1850-1 · Cited by 25
Multi-Target Approaches in Colon Cancer Chemoprevention Based on Systems Biology of Tumor Cell-Signaling
Guruswamy, S., & Rao, C. V. (2008) · Gene Regulation and Systems Biology · doi:10.4137/grsb.s486 · Cited by 23
“NFκB (Nuclear factor κB) is another important signaling molecule whose activation induces the expression of COX-2, which leads to tissue infl ammation (Yamamoto et al. 1995).”
Background
Natural gypenosides: targeting cancer through different molecular pathways
Ahmad, B., Khan, S., Nabi, G., Gamallat, Y., Su, P., Jamalat, Y., Duan, P., & Yao, L. (2019) · Cancer Management and Research · doi:10.2147/cmar.s185232 · Cited by 24
CD40 promotion of amyloid beta production occurs via the NF‐κB pathway
Ait‐Ghezala, G., Volmar, C., Frieling, J. S., Paris, D., Tweed, M., Bakshi, P., & MULLAN, M. J. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05424.x · Cited by 24
“This is exemplified by, for instance, mutation analysis of the COX-2 promoter region using a luciferase assay, which shows that the mutation of the NF-jB site results in a 63% decrease in luciferase activity (Yamamoto et al., 1995; D’Acquisto et al., 1997; Kniss et al., 2001).”
Method
3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells
Yadav, V. R., Prasad, S., Gupta, S. C., Sung, B., Phatak, S. S., Zhang, S., & Aggarwal, B. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.274613 · Cited by 22
Retracted
Roles of microRNAs in Regulating Cancer Stemness in Head and Neck Cancers
Fitriana, M., Hwang, W., Chan, P.-Y., Hsueh, T.-Y., & Liao, T. (2021) · Cancers · doi:10.3390/cancers13071742 · Cited by 24
“The NF-κB pathway maintains stemness by regulating many tumor-promoting inflammation-related cytokines, like tumor necrosis factor (TNF)-α [203], IL-1 [204], IL-6 [205,206], monocyte chemoattractant protein 1 (MCP1) [207], cytochrome oxidase subunit 2 (COX2) [203], and inducible nitric oxide synthase (iNOS) [203,208].”
Background
Inhibition of skin tumor promotion by TPA using a combination of topically applied ursolic acid and curcumin
Tremmel, L., Rho, O., Slaga, T. J., & DiGiovanni, J. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22918 · Cited by 22
Functional polymorphism of theNFKB1gene promoter is not relevant in predisposition to celiac disease
Rueda‐Medina, B., Núñez, C., López‐Nevot, M. Á., Ruiz, M. P., Urcelay, E., de la Concha, E. G., & Martin, J. J. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500325929 · Cited by 22
Cyclooxygenase‐2 inhibitor NS‐398 suppresses cell growth and constitutive production of granulocyte‐colony stimulating factor and granulocyte macrophage‐colony stimulating factor in lung cancer cells
Nakata, H., Uemura, Y., Kobayashi, M., Harada, R., & Taguchi, H. (2003) · Cancer Science · doi:10.1111/j.1349-7006.2003.tb01415.x · Cited by 22
Supplementary Materials and Methods
Groenendijk, F. H., Zwart, W. T., Floore, A. N., Akbari, S., & Bernards, R. (2013) · Cited by 22
Dexamethasone enhances trichosanthin-induced apoptosis in the HepG2 hepatoma cell line
Li, M., Chen, F., Liu, C., Li, D., Li, X., Wang, C., & Li, J. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.10.016 · Cited by 21
Transcription-based COX-2 inhibition: A therapeutic strategy
Wu, K. K. (2006) · Thrombosis and Haemostasis · doi:10.1160/th06-07-0403 · Cited by 21
Classic and Novel Signaling Pathways Involved in Cancer: Targeting the NF-κB and Syk Signaling Pathways
Tang, C., & Zhu, G. (2018) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x13666180723104340 · Cited by 21
Dihydro-N-caffeoyltyramine down-regulates cyclooxygenase-2 expression by inhibiting the activities of C/EBP and AP-1 transcription factors
Han, E. H., Kim, J. Y., Kim, H. G., Choi, J. H., Im, J. H., Woo, E. R., & Jeong, H. G. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.11.035 · Cited by 21
Recent Progress in the Cellular and Molecular Biology of Prostaglandin Synthesis
Herschman, H. R. (1998) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(98)00004-8 · Cited by 21
Promoter hypermethylation of cyclooxygenase-2 gene in esophageal squamous cell carcinoma
Meng, X., Zhu, S., Zong, Y., Wang, Y. J., Li, P., & Zhang, S. T. (2010) · Diseases of the Esophagus · doi:10.1111/j.1442-2050.2010.01159.x · Cited by 20
Phase 0 of the Xenobiotic Response: Nuclear Receptors and Other Transcription Factors As a First Step in Protection from Xenobiotics
Baldwin, W. S. (2019) · Nuclear Receptor Research · doi:10.32527/2019/101447 · Cited by 20
“Genes regulated by NF-κB include GSTP 1-1, COX-2, IL-1, C-reactive protein, phospholipase A2, DT-diaphorase, superoxide dismutase, α-1-antichymotrypsin, caspase 10, and IGF-BP1 [173-181] Comprehensive reviews on NF-κB can be found at [164, 173], or a website maintained by Dr.”
Background
Arachidonate 12-lipoxygenases with reference to their selective inhibitors
Yamamoto, S., Katsukawa, M., Nakano, A., Hiraki, E., Nishimura, K., Jisaka, M., Yokota, K., & Ueda, N. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.214 · Cited by 20
COX-2: an in vivo evidence of its participation in heat stress-induced myocardial preconditioning
Arnaud, C. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00295-5 · Cited by 20
“and nuclear factor kappa B (NF-B) [19], [28].”
Background
Effect of Mannitol on Helicobacter pylori-Induced Cyclooxygenase-2 Expression in Gastric Epithelial AGS Cells
Kim, H., Seo, J., & Kim, K. H. (2002) · Pharmacology · doi:10.1159/000065532 · Cited by 21
Bradykinin induces a rapid cyclooxygenase-2 mRNA expression via Ca2+mobilization in human gingival fibroblasts primed with interleukin-1 β
Nakao, S., Ogata, Y., Modéer, T., Segawa, M., Furuyama, S., & Sugiya, H. (2001) · Cell Calcium · doi:10.1054/ceca.2001.0206 · Cited by 20
Brucella Lipopolysaccharides Induce Cyclooxygenase-2 Expression in Monocytic Cells
López-Urrutia, L., Alonso, A., Bayón, Y., Nieto, M. L., Orduña, A., & Crespo, M. S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5995 · Cited by 20
Effects of calpain inhibitor I on multiple organ failure induced by zymosan in the rat*
Cuzzocrea, S., Chatterjee, P. K., Mazzon, E., Serraino, I., Dugo, L., Centorrino, T., Barbera, A., Ciccolo, A., Fulia, F., McDonald, M. C., et al. (2002) · Critical Care Medicine · doi:10.1097/00003246-200210000-00017 · Cited by 20
Cyclooxygenase-2 expression in non-Hodgkin's lymphomas
Paydaş, S., Ergin, M., Erdoğan, Ş., & Şeydaoğlu, G. (2007) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190601059787 · Cited by 19
Corosolic acid stimulates osteoblast differentiation by activating transcription factors and MAP kinases
Shim, K. S., Lee, S., Ryu, S. Y., Min, Y. K., & Kim, S. H. (2009) · Phytotherapy Research · doi:10.1002/ptr.2843 · Cited by 19
“Furthermore, NF-kB regulates the expression of genes specific to osteoblast differentiation (Yamamoto et al., 1995).”
Background
Regulation of Eicosanoid Pathways by MicroRNAs
Saul, M. J., Emmerich, A. C., Steinhilber, D., & Suess, B. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00824 · Cited by 19
“Various transcription factors such as NFκB, activator protein 1 (AP1), or the cAMP-responsive element-binding protein (CREB) are involved in its transcriptional regulation (Yamamoto et al., 1995; Kang et al., 2007).”
Background
Calcium-mediated increased expression of fibroblast growth factor-2 acts through NF-κB and PGE2/EP4 receptor signaling pathways in cementoblasts
Kanaya, S., Nemoto, E., Sakisaka, Y., & Shimauchi, H. (2013) · Bone · doi:10.1016/j.bone.2013.06.031 · Cited by 19
Inhibitory effect of triamcinolone acetonide on synthesis of inflammatory mediators in the equine
Mangal, D., Uboh, C. E., Soma, L. R., & Liu, Y. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.04.013 · Cited by 19
Uteroglobin Inhibits Prostaglandin F2α Receptor-mediated Expression of Genes Critical for the Production of Pro-inflammatory Lipid Mediators
Mandal, A. K., Ray, R., Zhang, Z., Chowdhury, B., Pattabiraman, N., & Mukherjee, A. B. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502375200 · Cited by 19
Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells
Ingram, A. J., James, L. R., Thai, K., Ly, H., Cai, L., & Scholey, J. W. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.2.f243 · Cited by 19
Barrett’s oesophagus: an ideal model to study cancer genetics
di Pietro, M., & Fitzgerald, R. C. (2009) · Human Genetics · doi:10.1007/s00439-009-0665-2 · Cited by 18
“Its expression has been shown to be responsive to NF-kB, a transcription factor which mediates an early transcriptional response in Barrett’s oesophagus in the context of inXammation (Yamamoto et al. 1995).”
Background
Activation of aryl hydrocarbon receptor signaling by gallic acid suppresses progression of human breast cancer in vitro and in vivo
Hanieh, H., Ibrahim, H.-I. M., Mohammed, M., Alwassil, O. I., Abukhalil, M. H., & Farhan, M. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153817 · Cited by 18
Human 5-lipoxygenase regulates transcription by association to euchromatin
Kreiß, M., Oberlis, J. H., Seuter, S., Bischoff‐Kont, I., Sürün, D., Thomas, D., Göbel, T., Schmid, T., Rådmark, O., Brandes, R. P., et al. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115187 · Cited by 20
“4A) [62 – 64].”
Involvement of inflammasomes in the pathogenesis of Alzheimer's disease
Beder, N., Belkhelfa, M., & Leklou, H. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241283677 · Cited by 20
Alleviative effects of s-allyl cysteine and s-ethyl cysteine on MCD diet-induced hepatotoxicity in mice
Lin, C.-C., Yin, M., & Liu, W. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.08.010 · Cited by 18
“It is well known that TNF-alpha could mediate the regulation of inflammation, endothelial dysfunction and coagulation; TGF-beta1 could induce the expression of type IV collagen and fibronectin (Yamamoto et al., 1995; Tang et al., 2002).”
Background
Teaching an old dog new tricks: reactivated developmental signaling pathways regulate ABCB1 and chemoresistance in cancer
Lee, W., & Thévenod, F. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2020.114 · Cited by 18
Effect of caffeic acid phenethyl ester on cartilage in experimental osteoarthritis
Elmalı, N., Ayan, İ., Türköz, Y., Mızrak, B., Germen, B., & Bora, A. (2002) · Rheumatology International · doi:10.1007/s00296-002-0232-9 · Cited by 18
“Nuclear factor jB also can induce activation of MMPs, cyclo-oxygenase-2 (COX-2), and inducible NO synthase (iNOS), the enzyme responsible for NO production [ 12 ].”
Background
Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase‐2 expression in neuroblastoma cells through a nuclear factor‐κB and activating protein‐1 mediated mechanism
Álvarez, S., Serramía, M. J., Fresno, M., & Muñoz‐Fernández, M. Á. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03267.x · Cited by 18
“For example, in macrophages, nuclear factor-jB (NF-jB) (Yamamoto et al. 1995), nuclear factor-IL-6/CCAAT-enhancer binding protein (Mestre et al. 2001) and cyclic AMPresponse element (CRE)-binding proteins (Mestre et al. 2001) are required for COX-2 transcriptional induction in response to variety…”
Background

Authors: Yamamoto, K., Arakawa, T., Ueda, N., & Yamamoto, S.
Affiliations: Tokushima University (JP)
Corresponding author: Yamamoto, Kei
Yamamoto, Shozo
ORCID: Yamamoto, Kei
Arakawa, Toshiya
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1995-12
Volume: 270
Issue: 52
Pages: 31315-31320
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.270.52.31315
OpenAlex: W2002708977
Cited by: 647
References: 38
Citations by year: 2026: 2 · 2025: 2 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 17 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 10 · 2015: 8 · 2014: 10 · 2013: 15 · 2012: 14
FWCI: 17.65
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9116 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Japan Foundation for Applied Enzymology
Japan Research Foundation for Clinical Pharmacology
Kissei
Ono Pharmaceutical
Japan Society for the Promotion of Science
Daiichi Sankyo Company
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: cyclooxygenase-2, NF-κB, NF-IL6, C/EBPβ, TNF-α, transcriptional regulation, prostaglandin E2, MC3T3-E1 cells, osteoblasts, promoter regulation, gene induction
MeSH terms: Animals, Base Sequence, DNA-Binding Proteins, Enzyme Induction, Isoenzymes, Molecular Sequence Data, Nuclear Proteins, Oligodeoxyribonucleotides, Promoter Regions, Genetic, Prostaglandin-Endoperoxide Synthases, Regulatory Sequences, Nucleic Acid, Transcription, Genetic, Tumor Necrosis Factor-alpha, NF-kappa B, 3T3 Cells, CCAAT-Enhancer-Binding Proteins, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transcriptional roles of nuclear factor κB and nuclear factor-interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks