The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Excitation-Transcription Coupling Mediated by Zinc Influx through Voltage-dependent Calcium Channels
Open accessAbstract
Electrical activity initiates a program of selective gene expression in excitable cells. Although such transcriptional activation is commonly attributed to depolarization-induced changes in intracellular Ca2+, zinc represents a viable alternative given its prominent role as a cofactor in DNA-binding proteins coupled with evidence that Zn2+ can enter excitable cells in a voltage-dependent manner. Here it is shown that Zn2+ entry into heart cells depends upon electrical stimulation and occurs via dihydropyridine-sensitive Ca2+ channels. The addition of extracellular Zn2+ to spontaneously depolarizing GH3 pituitary tumor cells induced the expression of a reporter gene driven by the metallothionein promoter, an effect that was prevented by exposure to dihydropyridine Ca2+ channel blockers. Thus, Zn2+ influx through L-type Ca2+ channels can mediate voltage-dependent gene expression.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Regulation of Gene Expression in Hippocampal Neurons by Distinct Calcium Signaling Pathways
Bading, H., Ginty, D. D., & Greenberg, M. E. (1993) · Science · doi:10.1126/science.8097060 · Cited by 1,157
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Metadata
- Authors
- Atar, D., Backx, P. H., Appel, M. M., Gao, W. D., & Marban, E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-02
- Volume
- 270
- Issue
- 6
- Pages
- 2473-2477
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2056925277
- Cited by
- 229
- References
- 2
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Atar, D., Backx, P. H., Appel, M. M., Gao, W. D., & Marban, E. (1995). Excitation-Transcription Coupling Mediated by Zinc Influx through Voltage-dependent Calcium Channels. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.6.2473
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
