A Di-leucine Motif and an Upstream Serine in the Interleukin-6 (IL-6) Signal Transducer gp130 Mediate Ligand-induced Endocytosis and Down-regulation of the IL-6 Receptor

Cited by (160)

Items 101–160 of 160

1. A complex of the soluble interleukin‐6 receptor and interleukin‐6 is internalized via the signal transducer gp130
   Lutz Graeve, Т. А. Короленко, Ulrike Hemmann, Oliver H. Weiergräber, Elke Dittrich, Peter Claus Heinrich · 1996 · FEBS Letters
2. Oncogenic deletion mutants of gp130 signal from intracellular compartments
   Dirk Schmidt‐Arras, Miryam Müller, Marija Stevanovic, Silke Horn, Antje Schütt, Juri Bergmann, Ruven Wilkens, Annett Lickert, Stefan Rose‐John · 2013 · Journal of Cell Science
3. SorLA in Interleukin-6 Signaling and Turnover
   Jakob Vejby Larsen, Claus Munck Petersen · 2017 · Molecular and Cellular Biology
4. Termination of IL‐6‐induced STAT activation is independent of receptor internalization but requires de novo protein synthesis
   Stefanie Thiel, U. Sommer, M. Kortylewski, C. Haan, I. Behrmann, Peter C. Heinrich, L. Graeve · 2000 · FEBS Letters
5. Structural Determinants Regulating Expression of the High Affinity Leukotriene B4 Receptor
   Rémi Gaudreau, Marie-Ève Beaulieu, Zhangguo Chen, Christian Le Gouill, Pierre Lavigne, Jana Staňková, Marek Rola‐Pleszczynski · 2004 · Journal of Biological Chemistry
6. A Balance of Opposing Signals within the Cytoplasmic Tail Controls the Lysosomal Targeting of P-selectin
   Anastasia D. Blagoveshchenskaya, Eric W. Hewitt, Daniel F. Cutler · 1998 · Journal of Biological Chemistry
7. SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
   Dorota Kmieć, Bengisu Akbil, Swetha Ananth, Dominik Hotter, Konstantin M. J. Sparrer, Christina Martina Stürzel, Birthe Trautz, Ahidjo Ayouba, Martine Peeters, Zhong Yao et al. · 2018 · PLoS Pathogens
8. Increased interleukin-6 receptor expression in the paraventricular nucleus of rats with heart failure
   Bryan Glen Helwig, Timothy I. Musch, Robin A. Craig, Michael Kenney · 2006 · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
9. Interleukin-6 controls recycling and degradation, but not internalization of its receptors
   Charlotte M. Flynn, Birte Kespohl, Tina Daunke, Yvonne Garbers, Stefan Düsterhöft, Stefan Rose‐John, Johannes Haybaeck, Juliane Lokau, Samadhi Aparicio-Siegmund, Christoph Garbers · 2021 · Journal of Biological Chemistry
10. Directed Covalent Immobilization of Fluorescently Labeled Cytokines
    Tobias Recker, Daniel Haamann, Anne Schmitt, Andrea Küster, Doris Klee, Stefan Barth, Gerhard Müller‐Newen · 2011 · Bioconjugate Chemistry
11. Role of the carboxyl terminal di-leucine in phosphorylation and internalization of C5a receptor
    Elena S. Suvorova, Jeannie M. Gripentrog, Martin Oppermann, Heini M. Miettinen · 2008 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
12. The Endocytosis and Signaling of the γδ T Cell Coreceptor WC1 Are Regulated by a Dileucine Motif
    Haoting Hsu, Cynthia L. Baldwin, Janice C. Telfer · 2015 · The Journal of Immunology
13. Mutational analysis of the carboxy-terminal phosphorylation site of GLUT-4 in 3T3-L1 adipocytes
    Brad J. Marsh, Sally Martin, Derek R. Melvin, Laura B. Martin, Richard A. Alm, Gwyn W. Gould, David Ernest James · 1998 · American Journal of Physiology-Endocrinology and Metabolism
14. Proteasome-Mediated Proteolysis of the Interleukin-10 Receptor Is Important for Signal Downregulation
    Sherry H.-Y. Wei, Andrew Ming‐Lum, Ying Liu, David Wallach, Christopher John Ong, Stephen W. Chung, Kevin W. Moore, Alice Mui · 2006 · Journal of Interferon & Cytokine Research
15. Molecular Characterization of the Signal Responsible for the Targeting of the Interleukin 2 Receptor β Chain toward Intracellular Degradation
    Agathe Subtil, Anna Rocca, Alice Dautry‐Varsat · 1998 · Journal of Biological Chemistry
16. Desensitization of Signaling by Oncostatin M in Human Vascular Cells Involves Cytoplasmic Tyr Residue 759 in gp130 but Is Not Mediated by Either Src Homology 2 Domain-containing Tyrosine Phosphatase 2 or Suppressor of Cytokine Signaling 3
    Keyvan Mahboubi, Nancy C. Kirkiles-Smith, Jim Karras, Jordan S. Pober · 2003 · Journal of Biological Chemistry
17. Integration of JAK/STAT receptor-ligand trafficking, signalling and gene expression in Drosophila melanogaster cells
    Rachel K. Moore, Katja L. Vogt, Adelina E. Acosta‐Martin, Patrick Shire, Martin Peter Zeidler, Elizabeth Smythe · 2020 · Journal of Cell Science
18. Plasticity and Rigidity in Adaptor Protein-2-Mediated Internalization of the TCR:CD3 Complex
    Andrea L. Szymczak-Workman, Dario A.A. Vignali · 2005 · The Journal of Immunology
19. Replacing factor‐dependency with that for lysozyme: Affordable culture of IL‐6‐dependent hybridoma by transfecting artificial cell surface receptor
    Masahiro Kawahara, Akito Natsume, Satoshi Terada, Koichi Kato, Kouhei Tsumoto, Izumi Kumagai, Masao Miki, Walter C. Mahoney, Hiroshi Ueda, Teruyuki Nagamune · 2001 · Biotechnology and Bioengineering
20. Intracellular Dynamics and Fate of a Humanized Anti–Interleukin-6 Receptor Monoclonal Antibody, Tocilizumab
    Keiko Fujimoto, Hiroaki Ida, Yuko Hirota, Masaki Ishigai, Jun Amano, Yoshitaka Tanaka · 2015 · Molecular Pharmacology
21. Calmodulin-dependent protein kinases phosphorylate gp130 at the serine-based dileucine internalization motif
    Robin M. Gibson, George S. Laszlo, Neil M. Nathanson · 2005 · Biochimica et Biophysica Acta (BBA) - Biomembranes
22. New Dominant-Negative IL6ST Variants Expand the Immunological and Clinical Spectrum of GP130-Dependent Hyper-IgE Syndrome
    Tiphaine Arlabosse, Marie Materna, Orbicia Riccio, Caroline Schnider, Federica Angelini, Matthieu Perreau, Isabelle Rochat, Andrea Superti‐Furga, Belinda Campos‐Xavier, Sébastien Héritier et al. · 2023 · Journal of Clinical Immunology
23. Identification of a basolateral sorting signal within the cytoplasmic domain of the interleukin-6 signal transducer gp130
    Jordan A. Doumanov, Merle Daubrawa, Heike Unden, Lutz Graeve · 2005 · Cellular Signalling
24. Identification of a Novel Binding Site Between HIV Type 1 Nef C-Terminal Flexible Loop and AP2 Required for Nef-Mediated CD4 Downregulation
    Yong‐Jiu Jin, Catherine Yi Cai, Mihaly Mezei, Michael H. J. Ohlmeyer, Roberto Sánchez, Steven J. Burakoff · 2012 · AIDS Research and Human Retroviruses
25. Dileucine and YXXL Motifs in the Cytoplasmic Tail of the Bovine Leukemia Virus Transmembrane Envelope Protein Affect Protein Expression on the Cell Surface
    Sinisa Novakovic, Earl T. Sawai, Kathryn Radke · 2004 · Journal of Virology
26. Colorectal cancer cell-derived interleukin-6 enhances the phagocytic capacity and migration of THP-1 cells
    Kun‐Yun Yeh, Tsung‐Han Wu, Tai-Ling Wu · 2016 · Cytokine
27. The Box-1 Region of the Leukemia Inhibitory Factor Receptor α-Chain Cytoplasmic Domain Is Sufficient for Hemopoietic Cell Proliferation and Differentiation
    Yu Zhang, Tracy A. Willson, Donald Metcalf, Dale Cary, Douglas J. Hilton, Roslyn Clark, Nicos Anthony Nicola · 1998 · Journal of Biological Chemistry
28. Transactivation of gp130 in Myeloma Cells 1
    J. French, D. K. Walters, D. Jelinek · 2003 · Journal of Immunology
29. Amino acid residues 268–276 of the erythropoietin receptor contain an endocytosis motif and are required for erythropoietin‐mediated proliferation
    Galit Flint-Ashtamker, Ronit Eisen-Lev, Jacob R. Cohen, Lily Jun-shen Huang, Drorit Neumann · 2002 · FEBS Letters
30. Endocytosis of pro-inflammatory cytokine receptors and its relevance for signal transduction
    Heike M. Hermanns, Julia Wohlfahrt, Christine Mais, Sabine Hergovits, Daniel Jahn, Andreas Geier · 2016 · Biological Chemistry
31. A 5′ distal palindrome within the mouse mammary tumor virus-long terminal repeat recruits a mammary gland-specific complex and is required for a synergistic response to progesterone plus prolactin
    Joseph E. Morabito, Josephine F. Trott, Dorian Korz, Heather E. Fairfield, Sarah H. Buck, Russell C. Hovey · 2008 · Journal of Molecular Endocrinology
32. Termination and modulation of IL-6-type cytokine signaling.
    Peter C. Heinrich, Johannes G. Bode, M. Decker, L. Graeve, Astrid S. Martens, G. Müller-Newen, S. Pflanz, F. Schaper, Jochen Schmitz · 2001 · Advances in Experimental Medicine and Biology
33. Cytoplasmic and Nuclear Cytokine Receptor Complexes
    Hichem C. Mertani, Gérard Morel, Peter Edward Lobie · 1997 · Vitamins and hormones
34. Eliminative Signaling by Janus Kinases: Role in the Downregulation of Associated Receptors
    Christopher J. Carbone, Serge Yu. Fuchs · 2013 · Journal of Cellular Biochemistry
35. Regulation of neurokine receptor signaling and trafficking
    Neil M. Nathanson · 2012 · Neurochemistry International
36. The gp130/STAT3-endoplasmic reticulum stress axis regulates hepatocyte necroptosis in acute liver injury
    Xia Li, Jie Wang, Ying Li, Wei He, Qijiao Cheng, Xia Liu, Delin Xu, Zhigang Jiang, Xue Xiao, Yi-Huai He · 2023 · Croatian Medical Journal
37. Exon–intron organization of the human gp130 gene
    C. Szalai, Sára Tóth, András Falus · 2000 · Gene
38. Hepatotoxicity: A Major Complication with Critical Treatment
    Sharma Mukesh K · 2015 · MOJ Toxicology
39. Understanding Prostate-Specific Membrane Antigen and Its Implication in Prostate Cancer
    Arundhati Ghosh, Warren D.W. Heston · 2005 · Humana Press eBooks
40. Differential functional coupling in Gp130-JAK complexes expands the plasticity of the interleukin-6 signaling axis
    Alison McFarlane, Junel Sotolongo Bellón, Thomas Meyer, Elizabeth Pöhler, Jacob Piehler, Ignacio Moraga · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
41. Divergent Pathways in COS-7 Cells Mediate Defective Internalization and Intracellular Routing of Truncated G-CSFR Forms in SCN/AML
    Melissa G Hunter, Morgan L. McLemore, Daniel C. Link, Megan Loveland, Alexander Z. Copelan, Belinda Rene Avalos · 2008 · PLoS ONE
42. Hepatotoxicity: A Major Complication with Critical Treatment
    Sharma Mukesh K · 2015 · MOJ Toxicology
43. gp130-mediated signalling as a therapeutic target
    Takuya Ohtani, Katsuhiko Ishihara, Toru Atsumi, Yuichi Yoshida, Keigo Nishida, Masahiro Narimatsu, Takahiro Shirogane, Masahiko Hibi, Toshio Hirano · 2000 · Emerging Therapeutic Targets
44. Negative-feedback Regulations Of Cytokine Signals
    Tadamitsu Kishimoto, Masashi Narazaki, Tetsuji Naka · 2000 · CRC Press eBooks
45. Fine mapping of heterozygous IL6ST nonsense variants underlying autosomal dominant hyper-IgE syndrome
    Kosuke Ashihara, Takaki Asano, Kanako Takeuchi, Kosuke Noma, Miyuki Tsumura, Wenjie Wang, Wei‐Te Lei, Hisao Higo, Toshio Kubo, Yoko Mizoguchi et al. · 2025 · JCI Insight
46. Current status of prediction of IL-6 mediated cytochrome P450 activity modulation using in vitro data and PBPK modeling
    V.P. Georgiev, Isabelle Anderka, Delia Bucher, Lena C. Preiss, Jitao David Zhang, Kenichi Umehara, Neil John Parrott · 2025 · Drug Metabolism and Pharmacokinetics
47. The role of the systemic inflammatory response, the JAK STAT pathway and the MAPK pathway in the prognosis of resectable pancreatic cancer
    Simon M. Denley · 2008 · OpenGrey (Institut de l'Information Scientifique et Technique)
48. Mimics of Growth Factors and Cytokines
    Jürgen Scheller, Joachim Grötzinger, Stefan Rose‐John · 2009
49. Eine neue Domäne der IL-6 Rezeptor β -Kette, gp130, vermittelt Zellwachstum und die Aktivierung der Kinasen Hck und Erk
    Schäffer, Michael · 2000 · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München)
50. JAK/STAT Signaling: A Tale of Jeeps and Trains
    Ana P. Costa‐Pereira, Birgit Strobl, Björn F. Lillemeier, Hayaatun Is’harc, Ian Macpherson Kerr · 2003 · Springer eBooks
51. Ligand-independent gp130-type receptor activation by forced homo- and heterodimerization
    Jan Suthaus · 2010 · MACAU: Open Access Repository of Kiel University (University Library Kiel)
52. Konstruktion und Charakterisierung eines konstitutiv aktiven Zytokin Rezeptors: gp130
    Sigrid Lang · 2004 · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)
53. COMMENTARY The ubiquitin-proteasome system and endocytosis
    Ger J. Strous, Roland Govers · 1999
54. The regulation of gp130 surface expression on monocytes : implications in chronic inflammation
    Nora Honke, P Idm, Rainer Fischer, Klaus Tenbrock · 2014 · RWTH Publications (RWTH Aachen)
55. Characterisation of a negative regulator of hydrophobic amino acid transport in Saccharomyces cerevisiae.
    Joanne M. Kingsbury · 2000 · UC Research Repository (University of Canterbury)
56. Konstruktion und Charakterisierung eines konstitutiv aktiven Zytokin Rezeptors: gp130
    Doktor der Naturwissenschaften · 2004
57. Effects of gp130 cytokines on adipocytes
    Sanjin Zvonic · 2004
58. Effects of methylxanthine on STAT3 mediated regulation of cytokines involved in tumor development and tumor induced angiogenesis in melanoma cells
    Mohammad Zahid Kamran · 2014 · INFLIBNET
59. Jak2, cytokines et récepteurs dans la polyglobulie de Vaquez
    Marjorie Boissinot · 2008
60. Struktur- und Funktionsuntersuchungen am humanen Interleukin-11-Rezeptorkomplex
    Ingrid Tacken, Peter Claus Heinrich · 2002 · RWTH Publications (RWTH Aachen)