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Unique Inactivation Properties of NAADP-sensitive Ca2+ Release
Open accessAbstract
Ca2+ mobilization from intracellular stores constitutes an important mechanism for generating cytoplasmic Ca2+ signals. Inositol trisphosphate (InsP3) and ryanodine receptors are the two families of intracellular Ca2+ release channels that have been identified, which may be regulated by separate intracellular messengers, InsP3, and cyclic adenosine 5'-diphosphate ribose, respectively. A third molecule, nicotinic acid adenine dinucleotide phosphate (NAADP), has recently been recognized as a potent Ca2+ releasing agent in sea urchin eggs and microsomes. We now report that non-releasing concentrations of NAADP fully and irreversibly inactivate the NAADP-sensitive Ca2+ release mechanism. This phenomenon occurred both in intact sea urchin eggs and in homogenates and is not shared by either InsP3 or cyclic adenosine 5'-diphosphate ribose. The novel properties of this Ca2+ release mechanism, giving a one-shot Ca2+ release, may be suited to irreversible cellular events.
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Cited by
Calcium signalling—an overview
Bootman, M. D., Collins, T. J., Peppiatt, C. M., Prothero, L. S., MacKenzie, L., De Smet, P., Travers, M., Tovey, S. C., Seo, J. T., Berridge, M. J., et al. (2001) · Seminars in Cell & Developmental Biology · doi:10.1006/scdb.2000.0211 · Cited by 531
Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers
Lee, H. C. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.317 · Cited by 433
Metadata
- Authors
- Genazzani, A. A., Empson, R. M., & Galione, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 271
- Issue
- 20
- Pages
- 11599-11602
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2063327869
- Cited by
- 163
- References
- 0
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Genazzani, A. A., Empson, R. M., & Galione, A. (1996). Unique Inactivation Properties of NAADP-sensitive Ca2+ Release. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.20.11599
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