A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism

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The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc

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Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

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IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System

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THE ROLE OF ENDOTHELIAL CELLS IN INFLAMMATION

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Participation of the Calcium/Calmodulin-dependent Kinases in Hydrogen Peroxide-induced IκB Phosphorylation in Human T Lymphocytes

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Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides

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Gene knockdown studies revealed CCDC50 as a candidate gene in mantle cell lymphoma and chronic lymphocytic leukemia

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Novel Pharmacologic Approaches to the Management of Sepsis: Targeting the Host Inflammatory Response

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Overexpression of A1, an NF-κB–Inducible Anti-Apoptotic Bcl Gene, Inhibits Endothelial Cell Activation

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Activation and regulation of Hsp32 and Hsp70

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Resistance of Human Ovarian Cancer Cells to Tumor Necrosis Factor α Is a Consequence of Nuclear Factor κB-Mediated Induction of Fas-Associated Death Domain-Like Interleukin-1β-Converting Enzyme-Like Inhibitory Protein

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TNFα-induced macrophage death via caspase-dependent and independent pathways

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A20 zinc finger protein inhibits TNF-induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF2 or 14-3-3 proteins

Lademann, U. A., Kallunki, T., & Jäättelä, M. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400805 · Cited by 51

αvβ3-integrin-dependent activation of focal adhesion kinase mediates NF-κB activation and motogenic activity by HIV-1 Tat in endothelial cells

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Interleukin 2 Activates Brain Microvascular Endothelial Cells Resulting in Destabilization of Adherens Junctions

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Localization of A20 to a lysosome-associated compartment and its role in NFκB signaling

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Role of NF-κB in Endotoxemia-Induced Alterations of Lung Neutrophil Apoptosis

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A20 INHIBITS NF-κB ACTIVATION DOWNSTREAM OF MULTIPLE MAP3 KINASES AND INTERACTS WITH THE IκB SIGNALOSOME

Zetoune, F. S., Murthy, A. R., Shao, Z., Hlaing, T., Zeidler, M. G., Li, Y., & Vincenz, C. (2001) · Cytokine · doi:10.1006/cyto.2001.0921 · Cited by 45

Oxidized LDL Suppresses NF-κB and Overcomes Protection from Apoptosis in Activated Endothelial Cells

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A20 Inhibits NF-κB Activation Independently of Binding to 14-3-3 Proteins

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ROS-induced ZNF580 expression: a key role for H2O2/NF-κB signaling pathway in vascular endothelial inflammation

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Loss of A20 in BM-MSCs regulates the Th17/Treg balance in Rheumatoid Arthritis

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Targeted inhibition of endothelial calpain delays wound healing by reducing inflammation and angiogenesis

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Infection of Endothelial Cells with Virulent Rickettsia prowazekii Increases the Transmigration of Leukocytes

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Anti‐inflammatory and anti‐osteoclastogenic effects of zinc finger protein A 20 overexpression in human periodontal ligament cells

Hong, J., Bae, W. ‐., Yi, J.-K., Kim, G., & Kim, E. ‐. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12332 · Cited by 40

ASSOCIATION OF GLUCOCORTICOIDS AND CYCLOSPORIN A OR RAPAMYCIN PREVENTS E-SELECTIN AND IL-8 EXPRESSION DURING LPS- AND TNF??-MEDIATED ENDOTHELIAL CELL ACTIVATION1

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Early Activation Signals in Endothelial Cells

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A20 Modulates Lipid Metabolism and Energy Production to Promote Liver Regeneration

Damrauer, S. M., Studer, P., da Silva, C. G., Longo, C. R., Ramsey, H. E., Csizmadia, E., Shrikhande, G., Scali, S. T., Libermann, T. A., Bhasin, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017715 · Cited by 37

TRANSIENT COMPLEMENT INHIBITION PLUS T-CELL IMMUNOSUPPRESSION INDUCES LONG-TERM SURVIVAL OF MOUSE-TO-RAT CARDIAC XENOGRAFTS1, 2

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Immune-Mediated Vascular Injury and Dysfunction in Transplant Arteriosclerosis

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Single Nucleotide Polymorphisms at the TNFAIP3/A20 Locus and Susceptibility/Resistance to Inflammatory and Autoimmune Diseases

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Lipopolysaccharide-Induced NF-κB Activation in Human Endothelial Cells Involves Degradation of IκBα but Not IκBβ

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Tumor Necrosis Factor (TNF)-α Persistently Activates Nuclear Factor-κB Signaling through the Type 2 TNF Receptor in Chromaffin Cells: Implications for Long-Term Regulation of Neuropeptide Gene Expression in Inflammation

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Zinc and Zinc Transporter Regulation in Pancreatic Islets and the Potential Role of Zinc in Islet Transplantation

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A Novel Leucine-Rich Repeat Protein (LRR-1): Potential Involvement in 4-1BB-mediated Signal Transduction

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TRAIL and inhibitors of apoptosis are opposing determinants for NF-κB-dependent, genotoxin-induced apoptosis of cancer cells

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Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells

Kunter, U., Daniel, S., Arvelo, M. B., Choi, J. Y., Shukri, T., Patel, V. I., Longo, C. R., Scali, S. T., Shrikhande, G., Rocha, E., et al. (2005) · Kidney International · doi:10.1111/j.1523-1755.2005.00564.x · Cited by 32

Endothelial monocyte activating polypeptide-II induced gene expression changes in endothelial cells

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Dysregulated Chemokine Signaling in Cystic Fibrosis Lung Disease: A Potential Therapeutic Target

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Gene activation by a CRISPR-assisted trans enhancer

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Deubiquitylating enzymes: potential target in autoimmune diseases

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SURVIVAL OF ACCOMMODATED CARDIAC XENOGRAFTS UPON RETRANSPLANTATION INTO CYCLOSPORINE-TREATED RECIPIENTS1,2

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Sulindac activates NF-κB signaling in colon cancer cells

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Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation

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Accommodation of xenografts: Expression of “protective genes” in endothelial and smooth muscle cells

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Characterization of focused ultrasound blood-brain barrier disruption effect on inflammation as a function of treatment parameters

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Improved renal function after kidney transplantation is associated with heme oxygenase‐1 polymorphism

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A20-Mediated Modulation of Inflammatory and Immune Responses in Aortic Allografts and Development of Transplant Arteriosclerosis

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The Universal NF-kappaB Inhibitor A20 Protects From Transplant Vasculopathy by Differentially Affecting Apoptosis in Endothelial and Smooth Muscle Cells

Daniel, S., Patel, V. I., Shrikhande, G., Scali, S. T., Ramsey, H. E., Csizmadia, E., Benhaga, N., Fisher, M. D., Arvelo, M. B., & Ferran, C. J. (2006) · Transplantation Proceedings · doi:10.1016/j.transproceed.2006.10.167 · Cited by 28

Ca2+ influx via TRPC channels induces NF-κB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells

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A20—A Bipartite Ubiquitin Editing Enzyme with Immunoregulatory Potential

Wertz, I. E., & Dixit, V. M. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0398-6_1 · Cited by 27

A20 Regulates Atherogenic Interferon (IFN)-γ Signaling in Vascular Cells by Modulating Basal IFNβ Levels

Moll, H. P., Lee, A., Minussi, D. C., da Silva, C. G., Csizmadia, E., Bhasin, M., & Ferran, C. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.591966 · Cited by 27

Temporal Network Based Analysis of Cell Specific Vein Graft Transcriptome Defines Key Pathways and Hub Genes in Implantation Injury

Bhasin, M., Huang, Z. S., Pradhan‐Nabzdyk, L., Malek, J. Y., LoGerfo, P. J., Contreras, M., Guthrie, P., Csizmadia, E., Andersen, N. D., Kocher, O. N., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039123 · Cited by 27

Synergistic Effects of Sonoporation and Taurolidin/TRAIL on Apoptosis in Human Fibrosarcoma

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TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma

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Adenovirus-mediated gene transfer of A20 renders endothelial cells resistant to activation: A means of evaluating the role of endothelial cell activation in xenograft rejection

Ferran, C. J., Stroka, D., Badrichani, A. Z., Cooper, J. T., & Bach, F. H. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(96)00184-4 · Cited by 25

Pleiotropic Effects of HTLV Type 1 Tax Protein on Cellular Metabolism: Mitotic Checkpoint Abrogation and NF- κ B Activation

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Cardiac functional improvement by a human Bcl-2 transgene in a mouse model of ischemia/reperfusion injury

Brocheriou, V., Hagège, A. A., Oubena�ssa, A., Lambert, M., Mallet, V. O., Duriez, M., Wassef, M., Kahn, A., Menasché, P., & Gilgenkrantz, H. (2000) · The Journal of Gene Medicine · doi:10.1002/1521-2254(200009/10)2:5 · Cited by 196

Protective Genes in the Vessel Wall: Modulators of Graft Survival and Function

Ferran, C. J. (2006) · Transplantation · doi:10.1097/01.tp.0000231445.62162.d5 · Cited by 24

A new role for the anti-apoptotic gene A20 in angiogenesis

Chng, H. W., Camplejohn, R. S., Stone, M. G., Hart, I. R., & Nicholson, L. J. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.05.015 · Cited by 24

A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi’s sarcoma-associated herpesvirus vFLIP oncoprotein

Sakakibara, S., Espígol‐Frigolé, G., Gasperini, P., Uldrick, T. S., Yarchoan, R., & Tosato, G. (2012) · Oncogene · doi:10.1038/onc.2012.145 · Cited by 23

The Promyelocytic Leukemia Protein Represses A20-mediated Transcription

Wu, W.-S., Xu, Z., & Chang, K.-S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201648200 · Cited by 23

GENE THERAPY AND TRANSPLANTATION1

Gojo, S., Cooper, D. K. C., Iacomini, J., & LeGuern, C. (2000) · Transplantation · doi:10.1097/00007890-200005270-00001 · Cited by 23

A20 (tnfaip3) is a negative feedback regulator of RIG-I-Mediated IFN induction in teleost

Mérour, E., Jami, R., Lamoureux, A., Bernard, J., Brémont, M., & Biacchesi, S. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.10.082 · Cited by 22

Significant lethality following liver resection in A20 heterozygous knockout mice uncovers a key role for A20 in liver regeneration

Studer, P., da Silva, C. G., Revuelta‐Cervantes, J., Mele, A. A., Csizmadia, E., Siracuse, J. J., Damrauer, S. M., Peterson, C. R., Candinas, D., Stroka, D., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.52 · Cited by 22

Modulation of the Vascular Endothelium during Infection - The Role of NF-κB Activation

Bierhaus, A., & Nawroth, P. P. (2002) · KARGER eBooks · doi:10.1159/000068133 · Cited by 22

Gene therapy and allotransplantation

Wood, K. J. (1997) · Current Opinion in Immunology · doi:10.1016/s0952-7915(97)80046-5 · Cited by 22

(E )‐2,4‐bis(p‐hydroxyphenyl)‐2‐butenal has an antiproliferative effect on NSCLC cells induced by p38 MAPK ‐mediated suppression of NF ‐κ B and up‐regulation of TNFRSF10B (DR5)

Kollipara, P. S., Jeong, H. S., Han, S., & Hong, J. T. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12024 · Cited by 21

Hepatocyte growth factor preferentially activates the anti‐inflammatory arm of NF‐κB signaling to induce A20 and protect renal proximal tubular epithelial cells from inflammation

da Silva, C. G., Maccariello, E. R., Wilson, S., Putheti, P., Daniel, S., Damrauer, S. M., Peterson, C. R., Siracuse, J. J., Kaczmarek, E., & Ferran, C. J. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22851 · Cited by 21

The role of A20 in the pathogenesis of lymphocytic malignancy

Zhang, F., Yang, L., & Li, Y. (2012) · Cancer Cell International · doi:10.1186/1475-2867-12-44 · Cited by 21

A20 Attenuates FFAs-induced Lipid Accumulation in Nonalcoholic Steatohepatitis

Ai, L., Xu, Q., Wu, C. W., Wang, X., Chen, Z., Su, D., Jiang, X., Xu, A., Lin, Q., & Fan, Z. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13371 · Cited by 21

A20, an essential component of the ubiquitin-editing protein complex, is a negative regulator of inflammation in human myometrium and foetal membranes

Lappas, M. (2017) · Molecular Human Reproduction · doi:10.1093/molehr/gax041 · Cited by 21

Activation of non-ischemic, hypoxia-inducible signalling pathways up-regulate cytoprotective genes in the murine liver

Plock, J. A., Frese, S., Keogh, A., Bisch-Knaden, S., Ayuni, E., Corazza, N., Weikert, C., Jakob, S. M., Erni, D., Dufour, J., et al. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.04.016 · Cited by 21

Tumor Necrosis Factor and Endothelial Cell Death

Karsan, A. (1998) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(97)00126-6 · Cited by 21

A20 deficiency leads to angiogenesis of pulmonary artery endothelial cells through stronger NF ‐κB activation under hypoxia

Li, J., Zhang, L., Zhang, Y., Liu, Y., Zhang, H., Wei, L., Shen, T., Jiang, C. L., & Zhu, D. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12816 · Cited by 19

Cytotoxic Role of Nitric Oxide in Diabetes

Heitmeier, M. R., & Corbett, J. A. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50050-2 · Cited by 19

A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation

Angolano, C., Kaczmarek, E., Essayagh, S., Daniel, S., Choi, L. Y., Tung, B., Sauvage, G., Lee, A., Kipper, F. C., Arvelo, M. B., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.651230 · Cited by 18

Feasibility of xeno-transplantation

Hoerbelt, R., & Madsen, J. C. (2004) · Surgical Clinics of North America · doi:10.1016/s0039-6109(03)00208-1 · Cited by 18

A20 regulates lymphocyte adhesion in murine neuroinflammation by restricting endothelial ICOSL expression in the CNS

Johann, L., Soldati, S. G., Müller, K., Lampe, J., Marini, F., Klein, M., Schramm, E., Ries, N., Schelmbauer, C., Palagi, I., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168314 · Cited by 19

The zinc finger protein A20 protects endothelial cells from burns serum injury

Zhu, C., Ying, D., Mi, J., Zhang, W., Dong, S., Sun, J., & Zhang, J.-P. (2004) · Burns · doi:10.1016/j.burns.2003.08.010 · Cited by 16

Induction of Protective Genes Leads to Islet Survival and Function

Wang, H., Ferran, C. J., Attanasio, C., Calise, F., & Otterbein, L. E. (2011) · Journal of Transplantation · doi:10.1155/2011/141898 · Cited by 15

Anti-Viral Tetris: Modulation of the Innate Anti-Viral Immune Response by A20

Arguello, M., Paz, S., Ferran, C. J., Moll, H. P., & Hiscott, J. B. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0398-6_4 · Cited by 15

Sequential Expression of Three Known Protective Genes in Cardiac Biopsies After Transplantation

Souza, A. I. D., Felkin, L. E., McCormack, A. M., Holder, A. L., Barton, P. J. R., Banner, N. R., & Rose, M. L. (2005) · Transplantation · doi:10.1097/01.tp.0000153154.37616.94 · Cited by 15

Protective genes expressed in endothelial cells of second hamster heart transplants to rats carrying an accommodated first graft

Hechenleitner, P., Mark, W., Candinas, D., Miyatake, T., Koyamada, N., Hancock, W. W., & Bach, F. H. (1996) · Xenotransplantation · doi:10.1111/j.1399-3089.1996.tb00149.x · Cited by 15

IL-8 and global gene expression analysis define a key role of ATP in renal epithelial cell responses induced by uropathogenic bacteria

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Vascular Injury Post Stent Implantation: Different Gene Expression Modulation in Human Umbilical Vein Endothelial Cells (HUVECs) Model

Campolo, J., Vozzi, F., Penco, S., Cozzi, L., Caruso, R., Domenici, C., Ahluwalia, A. D., Rial, M., Marraccini, P., & Parodi, O. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090213 · Cited by 13

Dynamism of NF-κB and AP-1 Activation in the Signal Transduction of Ischaemic Myocardial Preconditioning

Jancso, G., Lantos, J., Borsiczky, B., Szántó, Z., & Rőth, E. (2004) · European Surgical Research · doi:10.1159/000077253 · Cited by 13

The transfection of A20 gene prevents kidney from ischemia reperfusion injury in rats

Wei, L., Zhang, X., Ye, Q., Yang, Y., & Chen, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6725 · Cited by 13

A20 suppresses vascular inflammation by recruiting proinflammatory signaling molecules to intracellular aggresomes

Enesa, K., Moll, H. P., Luong, L. A., Ferran, C. J., & Evans, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-258533 · Cited by 12

A zebrafish functional genomics model to investigate the role of human A20 variants in vivo

Cultrone, D., Zammit, N. W., Self, E., Postert, B., Han, J. Z. R., Bailey, J., Warren, J. A., Croucher, D. R., Kikuchi, K., Bogdanović, O., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-75917-6 · Cited by 12

Zinc finger protein A20 protects rats against chronic liver allograft dysfunction

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A20 Haploinsufficiency Aggravates Transplant Arteriosclerosis in Mouse Vascular Allografts: Implications for Clinical Transplantation

Moll, H., Lee, A., Peterson, C. R., Cervantes, J. R., Wojcik, B. M., Parulkar, A., Mele, A., LoGerfo, P. J., Siracuse, J., Csizmadia, E., et al. (2016) · Transplantation · doi:10.1097/tp.0000000000001407 · Cited by 13

A20 Expressing Tumors and Anticancer Drug Resistance

da Silva, C. G., Minussi, D. C., Ferran, C. J., & Bredel, M. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-0398-6_5 · Cited by 11

Endothelial cells from bovine pulmonary microvasculature respond to Mycoplasma bovis preferentially with signals for mononuclear cell transmigration

Lü, X., & Rosenbusch, R. F. (2004) · Microbial Pathogenesis · doi:10.1016/j.micpath.2004.08.001 · Cited by 11

Elevated serum A20 is associated with severity of chronic hepatitis B and A20 inhibits NF-κB-mediated inflammatory response

Xu, H., Wang, L., Zheng, P., Liu, Y., Zhang, C., Jiang, K., Song, H., & Ji, G. (2017) · Oncotarget · doi:10.18632/oncotarget.17153 · Cited by 11

Molecular Mechanism of Preventive Effect of Peony Root Extract on Neuron Damage

Sunaga, K., Sugaya, E., Kajiwara, K., Tsuda, T., Sugaya, A., & Kimura, M. (2004) · Journal of Herbal Pharmacotherapy · doi:10.1080/j157v04n01_02 · Cited by 11

NFκB Activation During Ischemia/Reperfusion in Heart: Friend or Foe?

Kukreja, R. C. (2002) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2002.2067 · Cited by 11

The A20‐binding protein ABIN‐2 exerts unexpected function in mediating transcriptional coactivation

Chien, C.-Y., Liu, W.-K., Chou, C.-K., & Su, J.-Y. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00401-0 · Cited by 11

Pathogenesis of and potential therapies for delayed xenograft rejection

Soares, M. P., Lin, Y., Sato, K., Takigami, K., Anrather, J., Ferran, C. J., Robson, S. C., & Bach, F. H. (1999) · Current Opinion in Organ Transplantation · doi:10.1097/00075200-199903000-00015 · Cited by 11

Characterization of bovine A20 gene: Expression mediated by NF-κB pathway in MDBK cells infected with bovine viral diarrhea virus-1

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Genetic analysis of a mouse cross implicates an anti-inflammatory gene in control of atherosclerosis susceptibility

Garrett, N. E., III, Grainger, A. T., Li, J., Chen, M., & Shi, W. (2017) · Mammalian Genome · doi:10.1007/s00335-016-9677-0 · Cited by 10

Bovine Viral Diarrhoea Virus Infection Alters Global Transcription Profiles in Bovine Endothelial Cells

Neill, J. D., Ridpath, J. F., Lange, A., & Zuerner, R. L. (2008) · Developments in biologicals · doi:10.1159/000317148 · Cited by 10

Intraoperative biomarkers in renal transplantation

Lohkamp, L., Öllinger, R., Chatzigeorgiou, A., Illigens, B. M. W., & Siepmann, T. (2015) · Nephrology · doi:10.1111/nep.12556 · Cited by 10

A20 Inhibits NF-κB Activation in Endothelial Cells Without Sensitizing to Tumor Necrosis Factor–Mediated Apoptosis

Ferran, C. J., Stroka, D., Badrichani, A. Z., Cooper, J. T., Wrighton, C. J., Soares, M. P., Grey, S. T., & Bach, F. H. (1998) · Blood · doi:10.1182/blood.v91.7.2249 · Cited by 159

RAPID COMMUNICATION A20 Inhibits NF-kB Activation in Endothelial Cells Without Sensitizing to Tumor Necrosis Factor–Mediated Apoptosis

Ferran, C. J., Stroka, D. M., Badrichani, A. Z., Cooper, J. T., Wrighton, C. J., Soares, M., Grey, S. T., & Bach, F. H. (2016)

The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN

Heyninck, K., VALCK, D. D., Berghe, W. V., Criekinge, W. V., Contreras, R., Fiers, W., Haegeman, G., & Beyaert, R. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.7.1471 · Cited by 295

A20 expression inhibits endothelial cell activation

Cooper, J. T., Stroka, D., Brostjan, C., Palmetshofer, A., Bach, F. H., & Ferran, C. J. (1997) · Transplantation Proceedings · doi:10.1016/s0041-1345(96)00185-6 · Cited by 9

Article Role of A20 in cIAP-2 Protection against Tumor Necrosis Factor α (TNF-α)-Mediated Apoptosis in Endothelial Cells

Guo, S., Messmer-Blust, A. F., Wu, J., Song, X., Philbrick, M. J., Shie, J.-L., Rana, J. S., & Li, J. (2014)