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Innate Immunity
Open accessAbstract
We have isolated from the blood of immune-challenged and untreated mussels (Mytilus edulis) antibacterial and antifungal peptides. We have characterized two isoforms of a novel 34-residue, cysteine-rich, peptide with potent bactericidal activity and partially characterized a novel 6.2-kDa antifungal peptide containing 12 cysteines. We report the presence of two members of the insect defensin family of antibacterial peptides and provide a phylogenetic analysis that indicates that mollusc and arthropod defensins have a common ancestry. Our data argue that circulating antimicrobial peptides represent an ancient host defense mechanism that predated the separation between molluscs and arthropods at the root of the Cambrian, about 545 million years ago.
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Citations
Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
Anti-microbial peptides: from invertebrates to vertebrates
Bulet, P., Stöcklin, R., & Menin, L. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.0124.x · Cited by 1,107
Self-citationAntimicrobial peptides: premises and promises
Reddy, K. V. R., Yedery, R. D., & Aranha, C. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2004.09.005 · Cited by 1,068
Antimicrobial peptides in insects; structure and function
Bulet, P., Hetru, C., Dimarcq, J.-L., & Hoffmann, D. (1999) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(99)00015-4 · Cited by 1,041
Self-citationAntimicrobial peptides: key components of the innate immune system
Pasupuleti, M., Schmidtchen, A., & Malmsten, M. (2012) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2011.594423 · Cited by 799
Metadata
- Authors
- Charlet, M., Chernysh, S., Philippe, H., Hetru, C., Hoffmann, J. A., & Bulet, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 271
- Issue
- 36
- Pages
- 21808-21813
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2073626830
- Cited by
- 371
- References
- 0
- FWCI
- 5.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Innate Immunity. https://app.cochat.ai/papers/10.1074/jbc.271.36.21808
- The paper
- Charlet, M., Chernysh, S., Philippe, H., Hetru, C., Hoffmann, J. A., & Bulet, P. (1996). Innate Immunity. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.36.21808
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
