The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer
Open accessAbstract
The sequences of the metabotropic glutamate receptors (mGluRs) show little homology with other members of the G protein-coupled receptor family and exhibit several distinctive features, including a large N-terminal extracellular domain with 17 cysteines in conserved positions. Here we demonstrate that mGluR5, as well as other mGluRs, behave as species approximately twice as large as expected from their sequence, but reducing conditions cause a decrease to the predicted molecular mass. Co-immunoprecipitation experiments using wild type and epitope-tagged receptors demonstrate that this is due to specific, disulfide-dependent dimerization of the receptor. The intermolecular disulfide that mediates dimerization occurs in the extracellular domain, within about 17 kDa from the N terminus.
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Cites
A family of metabotropic glutamate receptors
Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992) · Neuron · doi:10.1016/0896-6273(92)90118-w · Cited by 940
Baude, A., Nusser, Z., Roberts, J. D. B., Mulvihill, E., Jeffrey Mcllhinney, R. A., & Somogyi, P. (1993) · Neuron · doi:10.1016/0896-6273(93)90086-7 · Cited by 927
Cited by
Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P. J., Neki, A., Abe, T., Nakanishi, S., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07503.1997 · Cited by 1,116
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Kew, J. N. C., & Kemp, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2200-z · Cited by 788
Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors
Pin, J.-P., Galvez, T., & Prézeau, L. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00038-x · Cited by 662
AT1-receptor heterodimers show enhanced G-protein activation and altered receptor sequestration
AbdAlla, S., Lother, H., & Quitterer, U. (2000) · Nature · doi:10.1038/35024095 · Cited by 503
Doumazane, E., Scholler, P., Zwier, J. M., Trinquet, E., Rondard, P., & Pin, J. (2011) · The FASEB Journal · doi:10.1096/fj.10-163147 · Cited by 324
Metadata
- Authors
- Romano, C., Yang, W.-L., & O'Malley, K. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 271
- Issue
- 45
- Pages
- 28612-28616
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2007051067
- Cited by
- 536
- References
- 2
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Romano, C., Yang, W.-L., & O'Malley, K. L. (1996). Metabotropic Glutamate Receptor 5 Is a Disulfide-linked Dimer. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.45.28612
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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