The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport
Open accessAbstract
The ATX1 gene of Saccharomyces cerevisiae was originally identified as a multi-copy suppressor of oxidative damage in yeast lacking superoxide dismutase. We now provide evidence that Atx1p helps deliver copper to the copper requiring oxidase Fet3p involved in iron uptake. atx1Delta null mutants are iron-deficient and are defective in the high affinity uptake of iron. These defects due to ATX1 inactivation are rescued by copper treatment, and the same has been reported for strains lacking either the cell surface copper transporter, Ctr1p, or the putative copper transporter in the secretory pathway, Ccc2p. Atx1p localizes to the cytosol, and our studies indicate that it functions as a carrier for copper that delivers the metal from the cell surface Ctr1p to Ccc2p and then to Fet3p within the secretory pathway. The iron deficiency of atx1 mutants is augmented by mutations in END3 blocking endocytosis, suggesting that a parallel pathway for intracellular copper trafficking is mediated by endocytosis. As additional evidence for the role of Atx1p in iron metabolism, we find that the gene is induced by the same iron-sensing trans-activator, Aft1p, that regulates CCC2 and FET3.
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Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,664
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,430
Ferrozine---a new spectrophotometric reagent for iron
Stookey, L. L. (1970) · Analytical Chemistry · doi:10.1021/ac60289a016 · Cited by 4,661
The Wilson disease gene is a putative copper transporting P–type ATPase similar to the Menkes gene
Bull, P. C., Thomas, G. R., Rommens, J. M., Forbes, J. R., & Cox, D. W. (1993) · Nature Genetics · doi:10.1038/ng1293-327 · Cited by 1,948
Methods in Yeast Genetics: A Laboratory Course Manual
Rose, M. D., Winston, F., & Hieter, P. (1990) · Medical Entomology and Zoology · Cited by 1,894
Vulpe, C., Levinson, B., Whitney, S., Packman, S., & Gitschier, J. (1993) · Nature Genetics · doi:10.1038/ng0193-7 · Cited by 1,418
Methods in Yeast Genetics — A Laboratory Course Manual
Radford, A. (1991) · Biochemical Education · doi:10.1016/0307-4412(91)90039-b · Cited by 1,235
Synaptic vesicle membrane fusion complex: action of clostridial neurotoxins on assembly.
Hayashi, T., McMahon, H., Yamasaki, S., Binz, T., Hata, Y., Südhof, T. C., & Niemann, H. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06834.x · Cited by 797
[12] High-efficiency transformation of yeast by electroporation
(1991) · Methods in Enzymology · doi:10.1016/0076-6879(91)94015-5 · Cited by 788
Chelly, J., Tümer, Z., Tønnesen, T., Petterson, A., Ishikawa-Brush, Y., Tommerup, N., Horn, N., & Monaco, A. P. (1993) · Nature Genetics · doi:10.1038/ng0193-14 · Cited by 726
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Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
Rae, T. D., Schmidt, P. J., Pufahl, R. A., Culotta, V. C., & V. O'Halloran, T. (1999) · Science · doi:10.1126/science.284.5415.805 · Cited by 1,629
Self-citationTransition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors
Finney, L. A., & O'Halloran, T. V. (2003) · Science · doi:10.1126/science.1085049 · Cited by 1,100
Self-citationThe Copper Chaperone for Superoxide Dismutase
Culotta, V. C., Klomp, L. W. J., Strain, J., Casareno, R. L. B., Krems, B., & Gitlin, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23469 · Cited by 850
Self-citationMetallochaperones, an Intracellular Shuttle Service for Metal Ions
O'Halloran, T. V., & Culotta, V. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000006200 · Cited by 806
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Metadata
- Authors
- Lin, S.-J., Pufahl, R. A., Dancis, A., O'Halloran, T. V., & Culotta, V. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-04
- Volume
- 272
- Issue
- 14
- Pages
- 9215-9220
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011444292
- Cited by
- 411
- References
- 46
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lin, S.-J., Pufahl, R. A., Dancis, A., O'Halloran, T. V., & Culotta, V. C. (1997). A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.14.9215
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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