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Effect of S(−) perillic acid on protein prenylation and arterial smooth muscle cell proliferation☆2☆This research was partially supported by Institut of Recherches Internationales Servier, Paris, France. N. Ferri, L. Arnaboldi, and A. Corsini are also partially supported by a grant from the Ministero dell’Università e della Ricerca Scientifica e Tecnologica (cofinanziamento 1999, progetto “Role of smooth muscle cells in atherogenesis: pharmacological implications,” protocollo 9905157119. M. H. Gelb and K. Yokoyama are supported by a Grant from the National Institute of Health (CA 52874). A. Corsini is a visiting scientist under the terms of the US (National Heart, Lung, and Blood Institute)-Italy bilateral agreement in the cardiovascular area.2Abbreviations: FOH, farnesol; GGOH, geranylgeraniol; PFTase, protein farnesyltransferase; PGGTase, protein geranylgeranyltransferase; PA, perillic acid; SMC, smooth muscle cell; MVA, mevalonate; HMG-CoA, 3-hydroxy-3-methyl-glutaryl coenzyme A; FCS, fetal calf serum; MEM, Minimum Essential Medium; PBS, phosphate buffered saline; PI, propidium iodide.

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