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Cited by 308

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Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion

Open access
Yamamoto, Makiko, Bharti, Ajit, Li, Yongqing, Kufe, Donald·1997·Journal of Biological Chemistry

Abstract

The DF3/MUC1 mucin-like glycoprotein is aberrantly overexpressed in human breast carcinomas. The functional role of DF3 is unknown. The present studies demonstrate that DF3 associates with beta-catenin. Similar findings have been obtained for gamma-catenin but not alpha-catenin. DF3, like E-cadherin and the adenomatous polyposis coli gene product, contains an SXXXXXSSL site that is responsible for direct binding to beta-catenin. The results further demonstrate that interaction of DF3 and beta-catenin is dependent on cell adhesion. These findings and the role of beta-catenin in cell signaling support a role for DF3 in the adhesion of epithelial cells.

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Metadata

Authors
Yamamoto, M., Bharti, A., Li, Y., & Kufe, D.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1997-05
Volume
272
Issue
19
Pages
12492-12494
ISSN
0021-9258 (ISSN-L)
OpenAlex
W2010571201
Cited by
308
References
0
FWCI
2.70
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion. https://app.cochat.ai/papers/10.1074/jbc.272.19.12492
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Yamamoto, M., Bharti, A., Li, Y., & Kufe, D. (1997). Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.19.12492

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.