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Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction
Open accessAbstract
In a process inhibited by the quinoline antimalarial drugs, Plasmodia detoxify heme released during the degradation of hemoglobin by aggregating it into malarial pigment, an insoluble crystalline heme coordination polymer. Synchrotron x-ray powder diffraction patterns for intact desiccated malarial trophozoites and synthetic beta-hematin have been measured; both materials correspond to a single crystalline triclinic lattice with unit cell parameters a = 12.2176(4), b = 14.7184(5), c = 8.0456(3) A; alpha = 90.200(2), beta = 96.806(3), gamma = 97.818(3) degrees and Z = 2. These results unambiguously demonstrate that hemozoin crystallites are identical to synthetic beta-hematin.
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Cited by
Quinoline Antimalarials Mechanisms of Action and Resistance and Prospects for New Agents
Foley, M. (1998) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(98)00012-6 · Cited by 592
Egan, T. J., Hunter, R., Kaschula, C. H., Marques, H. M., Misplon, A., & Walden, J. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990437l · Cited by 317
Malarial hemozoin: From target to tool
Coronado, L. M., Nadovich, C. T., & Spadafora, C. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.02.009 · Cited by 289
The Peculiarities and Paradoxes of Plasmodium Heme Metabolism
Sigala, P. A., & Goldberg, D. E. (2014) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091313-103537 · Cited by 129
(1998) · PubMed Central
Metadata
- Authors
- Bohle, D. S., Dinnebier, R. E., Madsen, S. K., & Stephens, P. W.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-01
- Volume
- 272
- Issue
- 2
- Pages
- 713-716
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2040765604
- Cited by
- 166
- References
- 0
- FWCI
- 17.12
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction. https://app.cochat.ai/papers/10.1074/jbc.272.2.713
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- Bohle, D. S., Dinnebier, R. E., Madsen, S. K., & Stephens, P. W. (1997). Characterization of the Products of the Heme Detoxification Pathway in Malarial Late Trophozoites by X-ray Diffraction. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.2.713
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