The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair
Open accessAbstract
DNA ligase III and the essential protein XRCC1 are present at greatly reduced levels in the xrcc1 mutant CHO cell line EM-C11. Cell-free extracts prepared from these cells were used to examine the role of the XRCC1 gene product in DNA base excision repair in vitro. EM-C11 cell extract was partially defective in ligation of base excision repair patches, in comparison to wild type CHO-9 extracts. Of the two branches of the base excision repair pathway, only the single nucleotide insertion pathway was affected; no ligation defect was observed in the proliferating cell nuclear antigen-dependent pathway. Full complementation of the ligation defect in EM-C11 extracts was achieved by addition to the repair reaction of recombinant human DNA ligase III but not by XRCC1. This is consistent with the notion that XRCC1 acts as an important stabilizing factor of DNA ligase III. These data demonstrate for the first time that xrcc1 mutant cells are partially defective in ligation of base excision repair patches and that the defect is specific to the polymerase beta-dependent single nucleotide insertion pathway.
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Citations
Cites
Instability and decay of the primary structure of DNA
Lindahl, T. (1993) · Nature · doi:10.1038/362709a0 · Cited by 5,679
Cited by
Masson, M., Niedergang, C., Schreiber, V., Muller, S., Menissier-de Murcia, J., & de Murcia, G. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3563 · Cited by 910
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753
Cellular Responses to DNA Damage
Norbury, C. J., & Hickson, I. D. (2001) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.41.1.367 · Cited by 623
Whitehouse, C. J., Taylor, R. M., Thistlethwaite, A., Zhang, H., Karimi-Busheri, F., Lasko, D. D., Weinfeld, M., & Caldecott, K. W. (2001) · Cell · doi:10.1016/s0092-8674(01)00195-7 · Cited by 608
Self-citationMolecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
Kohn, K. W. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.8.2703 · Cited by 560
Metadata
- Authors
- Cappelli, E., Taylor, R., Cevasco, M., Abbondandolo, A., Caldecott, K., & Frosina, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-09
- Volume
- 272
- Issue
- 38
- Pages
- 23970-23975
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2013210712
- Cited by
- 333
- References
- 1
- FWCI
- 5.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cappelli, E., Taylor, R., Cevasco, M., Abbondandolo, A., Caldecott, K., & Frosina, G. (1997). Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.38.23970
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