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Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers
Open accessAbstract
Intoxication of mammalian cells with the vacuolating toxin (VacA) released by Helicobacter pylori causes the formation of large acidic vacuoles containing the vacuolar ATPase proton pump and Rab7, a late endosome marker. Here, we describe a novel subcellular fractionation procedure, and we show that nanomolar concentrations of VacA induce a clear redistribution of lysosomal membrane glycoproteins among endocytic compartments. This redistribution is an early event in the process of cellular intoxication by VacA and precedes the formation of macroscopic vacuoles. The absence of the cation independent mannose 6-P receptor and the presence of Rab7 and of lysosomal membrane proteins in the newly formed compartment suggest that the vacuolating toxin induces the accumulation of a post-endosomal hybrid compartment presenting both late endosomal and lysosomal features.
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Citations
Cited by
Helicobacter pylori Virulence and Genetic Geography
Covacci, A., Telford, J. L., Giudice, G. D., Parsonnet, J., & Rappuoli, R. (1999) · Science · doi:10.1126/science.284.5418.1328 · Cited by 1,049
Self-citationPersistent bacterial infections: the interface of the pathogen and the host immune system
Monack, D. M., Mueller, A., & Falkow, S. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro955 · Cited by 572
Rhead, J. L., Letley, D. P., Mohammadi, M., Hussein, N., Mohagheghi, M. A., Eshagh Hosseini, M., & Atherton, J. C. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.056 · Cited by 435
Motyka, B., Korbutt, G., Pinkoski, M. J., Heibein, J. A., Caputo, A., Hobman, M., Barry, M., Shostak, I., Sawchuk, T., Holmes, C. F. B., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00140-9 · Cited by 398
Steele-Mortimer, O., Meresse, S., Gorvel, J.-P., Toh, B.-H., & Finlay, B. B. (1999) · Cellular Microbiology · doi:10.1046/j.1462-5822.1999.00003.x · Cited by 334
Metadata
- Authors
- Molinari, M., Galli, C., Norais, N., Telford, J. L., Rappuoli, R., Luzio, J. P., & Montecucco, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-10
- Volume
- 272
- Issue
- 40
- Pages
- 25339-25344
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1995163933
- Cited by
- 186
- References
- 0
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Molinari, M., Galli, C., Norais, N., Telford, J. L., Rappuoli, R., Luzio, J. P., & Montecucco, C. (1997). Vacuoles Induced by Helicobacter pylori Toxin Contain Both Late Endosomal and Lysosomal Markers. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.40.25339
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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