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Understanding Enzyme Superfamilies
Open accessAbstract
We have described four superfamilies of enzymes where the members within each catalyze different overall reactions using broadly varied substrates. Within each superfamily, the different overall reactions are facilitated by a common mechanistic strategy that can be rationalized in the context of the structural scaffold. Although space limitations prevent their discussion, a number of additional superfamilies have been described in which these principles appear to obtain. Analyses of the relationships between structure and function in all of these superfamilies suggest two general conclusions regarding the evolution of new catalytic activities.
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Cited by
Origin and evolution of metabolic pathways
Fani, R., & Fondi, M. (2009) · Physics of Life Reviews · doi:10.1016/j.plrev.2008.12.003 · Cited by 117
Gulick, A. M., Hubbard, B. K., Gerlt, J. A., & Rayment, I. (2001) · Biochemistry · doi:10.1021/bi010733b · Cited by 25
Self-citationAngeletti, A., Migliorini, P., Bruschi, M., Pratesi, F., Candiano, G., Prunotto, M., Verrina, E., & Ghiggeri, G. M. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102977 · Cited by 18
Identification of sequence determinants for the ABHD14 enzymes
Vaidya, K., Rodrigues, G., Gupta, S., Devarajan, A., Yeolekar, M., Madhusudhan, M. S., & Kamat, S. S. (2025) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.26632 · Cited by 9
Metadata
- Authors
- Babbitt, P. C., & Gerlt, J. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 272
- Issue
- 49
- Pages
- 30591-30594
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2017661263
- Cited by
- 272
- References
- 0
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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