The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase
Open accessAbstract
Clones encoding a new human P2Y receptor, provisionally called P2Y11, have been isolated from human placenta complementary DNA and genomic DNA libraries. The 1113-base pair open reading frame is interrupted by one intron. The P2Y11 receptor is characterized by considerably larger second and third extracellular loops than the subtypes described so far. The deduced amino acid sequence exhibits 33% amino acid identity with the P2Y1 receptor, its closest homolog. Northern blot analysis detected human P2Y11 receptor messenger RNA in spleen and HL-60 cells. The level of P2Y11 transcripts was strongly increased in these cells after granulocyte differentiation induced by retinoic acid or dimethyl sulfoxide. The new receptor was stably expressed in 1321N1 astrocytoma and CHO-K1 cells, where it couples to the stimulation of both the phosphoinositide and adenylyl cyclase pathways, a unique feature among the P2Y family. The rank order of agonists potency was: ATP > 2-methylthio-ATP >>> ADP, whereas UTP and UDP were inactive, indicating that it behaves as a selective purinoceptor.
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Cites
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid
Breitman, T. R., Selonick, S. E., & Collins, S. J. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.2936 · Cited by 1,966
Cited by
Pharmacological characterization of the human P2Y11 receptor
Communi, D., Robaye, B., & Boeynaems, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702909 · Cited by 271
Self-citationA sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo
Wu, Z., He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Xi, F., Deng, F., Wang, H., et al. (2022) · Neuron · doi:10.1016/j.neuron.2021.11.027 · Cited by 204
Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti
Piazza, V., Ciubotaru, C. D., Gale, J. E., & Mammano, F. (2007) · Cell Calcium · doi:10.1016/j.ceca.2006.05.005 · Cited by 105
Metadata
- Authors
- Communi, D., Govaerts, C., Parmentier, M., & Boeynaems, J.-M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-12
- Volume
- 272
- Issue
- 51
- Pages
- 31969-31973
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1981183509
- Cited by
- 341
- References
- 1
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Communi, D., Govaerts, C., Parmentier, M., & Boeynaems, J.-M. (1997). Cloning of a Human Purinergic P2Y Receptor Coupled to Phospholipase C and Adenylyl Cyclase. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.51.31969
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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