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A Role for Sam68 in Cell Cycle Progression Antagonized by a Spliced Variant within the KH Domain
Open accessAbstract
Sam68 is the main tyrosine-phosphorylated and Src-associated protein in mitotic cells. Sam68 exhibits a conserved functional KH (hnRNPK homology) RNA binding domain and binds single strand nucleic acids. Tyrosine phosphorylation mediates the interaction of Sam68 with many SH3- and SH2-containing proteins and negatively regulates its nucleic acid binding properties. But the function and the impact of Sam68 on cell signaling and cell proliferation remains elusive. We report here the identification of a natural isoform of Sam68 with a deletion within the KH domain. This isoform, called Sam68DeltaKH, is specifically expressed at growth arrest upon confluency in normal cells. In cells that do not enter quiescence at confluency such as Src-transformed cells, no recruitment of Sam68DeltaKH is observed. Transfected Sam68DeltaKH inhibits serum-induced DNA synthesis and cyclin D1 expression. Sam68 overcomes these effects, suggesting that isoforms of Sam68 are involved, through KH domain signaling, in cell proliferation, and more precisely in G1/S transition.
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“Several noteworthy interactions include a regulator of cell cycle progression, KHDRBS1 (ref. 72), the oxygen sensor, EGLN2 (ref. 73), and a stabilizer of p53, BRI3BP74”
From The origins and genetic interactions of KRAS mutations are allele- and tissue-specific (2021) · cites this paper as [72]
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Cyclin D1 is a nuclear protein required for cell cycle progression in G1
Baldin, V, Lukas, J., Marcote, M. J., Pagano, M., & Draetta, G. (1993) · Genes & Development · doi:10.1101/gad.7.5.812 · Cited by 1,614
Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.Preprint
Quelle, D. E., Ashmun, R. A., Shurtleff, S. A., Kato, J., Bar‐Sagi, D., Roussel, M. F., & Sherr, C. J. (1993) · Genes & Development · doi:10.1101/gad.7.8.1559 · Cited by 1,031
Association between the PDGF receptor and members of the src family of tyrosine kinases
Kypta, R. M., Goldberg, Y., Ulug, E. T., & Courtneidge, S. A. (1990) · Cell · doi:10.1016/0092-8674(90)90013-5 · Cited by 635
Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
Kiledjian, M., & Dreyfuss, G. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05331.x · Cited by 619
An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis
Taylor, S. J., & Shalloway, D. I. (1994) · Nature · doi:10.1038/368867a0 · Cited by 412
Fumagalli, S., Totty, N. F., Hsuan, J. J., & Courtneidge, S. A. (1994) · Nature · doi:10.1038/368871a0 · Cited by 365
Swanson, M. S., & Dreyfuss, G. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.5.2237 · Cited by 331
Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
Barone, M. V., & Courtneidge, S. A. (1995) · Nature · doi:10.1038/378509a0 · Cited by 308
Wong, G. A., Müller, O., Clark, R., Conroy, L., Moran, M. F., Polakis, P. G., & McCormick, F. (1992) · Cell · doi:10.1016/0092-8674(92)90455-l · Cited by 258
Requirement for Src Family Protein Tyrosine Kinases in G 2 for Fibroblast Cell Division
Roche, S., Fumagalli, S., & Courtneidge, S. A. (1995) · Science · doi:10.1126/science.7545311 · Cited by 252
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- Weng, 1994, Mol. Cell. Biol., 14, 4509
- Swanson, 1988, Mol. Cell. Biol., 8, 2237
- Gould, 1988, Mol. Cell. Biol., 8, 3345
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Items 101–111 of 111
RNA Binding Protein Khdrbs1 Regulates Hematopoietic Stem and Progenitor Cell Emergence via SplicingPreprint
Karp, I., & Bowman, T. V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.01.621494
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927056
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927077
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927062
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927059
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927065
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927068
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927071
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927053
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927080
Liao, W.-T., Liu, J.-L., Wang, Z.-G., Cui, Y.-M., Shi, L., Li, T.-T., Zhao, X., Chen, X.-T., Ding, Y.-Q., & Song, L.-B. (2021) · Figshare · doi:10.6084/m9.figshare.14927074
Metadata
- Authors
- Barlat, I., Maurier, F., Duchesne, M., Guitard, E., Tocque, B., & Schweighoffer, F.
- Corresponding author
- Schweighoffer, Fabien
- ORCID
- Maurier, Florence
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 272
- Issue
- 6
- Pages
- 3129-3132
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2026506733
- Cited by
- 111
- References
- 22
- Citations by year
- 2024: 4 · 2023: 2 · 2021: 12 · 2019: 2 · 2018: 1 · 2016: 4 · 2015: 3 · 2013: 5 · 2012: 2
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- Sam68, KH domain, alternative splicing, protein isoforms, cell cycle progression, G1/S transition, cyclin D1, tyrosine phosphorylation, RNA binding, cell proliferation, quiescence, confluency, DNA synthesis
- MeSH terms
- Cell Cycle, DNA-Binding Proteins, Humans, Phosphoproteins, Phosphorylation, Structure-Activity Relationship, Transfection, Tyrosine, Polymerase Chain Reaction, S Phase, RNA-Binding Proteins, Adaptor Proteins, Signal Transducing
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