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G Protein-coupled Receptors
Open accessAbstract
The majority of transmembrane signal transduction in response to hormones and neurotransmitters is mediated by G protein-coupled receptors (GPCRs). 1 Moreover, GPCRs are the principal signal transducers for the senses of sight and smell. GPCRs are characterized by seven membrane-spanning domains with an extracellular N terminus and a cytoplasmic C terminus (Fig. 1) (GPCR structure reviewed in Refs.1-3). Based on certain key sequences, GPCRs can be divided into three major subfamilies, receptors related to rhodopsin (type A), receptors related to the calcitonin receptor (type B), and receptors related to the metabotropic receptors (type C).
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Cited by
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Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
A transmembrane intracellular estrogen receptor mediates rapid cell signaling
Revankar, C. M., Cimino, D. F., Sklar, L. A., Arterburn, J. B., & Prossnitz, E. R. (2005) · Science · doi:10.1126/science.1106943 · Cited by 2,302
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
Olsen, R. H. J., DiBerto, J. F., English, J. G., Glaudin, A. M., Krumm, B. E., Slocum, S. T., Che, T., Gavin, A. C., McCorvy, J. D., Roth, B. L., et al. (2020) · Nature Chemical Biology · doi:10.1038/s41589-020-0535-8 · Cited by 544
Expression analysis of G Protein-Coupled Receptors in mouse macrophages
Lattin, J. E., Schroder, K., Su, A. I., Walker, J. R., Zhang, J., Wiltshire, T., Saijo, K., Glass, C. K., Hume, D. A., Kellie, S., et al. (2008) · Immunome Research · doi:10.1186/1745-7580-4-5 · Cited by 438
Metadata
- Authors
- Gether, U., & Kobilka, B. K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 273
- Issue
- 29
- Pages
- 17979-17982
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1970736649
- Cited by
- 578
- References
- 0
- FWCI
- 17.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
