The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Expression of PEX11β Mediates Peroxisome Proliferation in the Absence of Extracellular Stimuli
Open accessAbstract
Mammalian cells typically contain hundreds of peroxisomes but can increase peroxisome abundance further in response to extracellular stimuli. We report here the identification and characterization of two novel human peroxisomal membrane proteins, PEX11alpha and PEX11beta. Overexpression of the human PEX11beta gene alone was sufficient to induce peroxisome proliferation, demonstrating that proliferation can occur in the absence of extracellular stimuli and may be mediated by a single gene. Time course studies indicated that PEX11beta induces peroxisome proliferation through a multistep process involving peroxisome elongation and segregation of PEX11beta from other peroxisomal membrane proteins, followed by peroxisome division. Overexpression of PEX11alpha also induced peroxisome proliferation but at a much lower frequency than PEX11beta in our experimental system. The patterns of PEX11alpha and PEX11beta expression were examined in the rat, the animal in which peroxisome proliferation has been examined most extensively. Levels of PEX11beta mRNA were similar in all tissues examined and were unaffected by peroxisome-proliferating agents. Conversely, PEX11alpha mRNA levels varied widely among different tissues, were highest in tissues that are sensitive to peroxisome-proliferating agents, and were induced more than 10-fold in response to the peroxisome proliferators clofibrate and di(2-ethylhexyl) phthalate. Taken together, these data implicate PEX11beta in the constitutive control of peroxisome abundance and suggest that PEX11alpha may regulate peroxisome abundance in response to extracellular stimuli.
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“PEX11β was shown to mediate peroxisome proliferation in the absence of external stimuli (Schrader et al., 1998). It facilitates peroxisome fission by promoting membrane deformation that depends on its self-dimerization (Bonekamp et al., 2013).”
From The cell biology of the retinal pigment epithelium (2020) · cites this paper as Schrader et al., 1998
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Self-citationWang, Z., Morris, J. C., Drew, M. E., & Englund, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m008405200 · Cited by 519
Smith, J. J., & Aitchison, J. D. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3700 · Cited by 470
The cell biology of the retinal pigment epithelium
Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K., & Williams, D. S. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100846 · Cited by 422
Diverse intracellular pathogens activate type III interferon expression from peroxisomes
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Metadata
- Authors
- Schrader, M., Reuber, B. E., Morrell, J. C., Jimenez-Sanchez, G., Obie, C., Stroh, T. A., Valle, D., Schroer, T. A., & Gould, S. J.
- Affiliations
- Johns Hopkins University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Gould, Stephen J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 273
- Issue
- 45
- Pages
- 29607-29614
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2071649496
- Cited by
- 266
- References
- 22
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 14 · 2014: 11 · 2013: 10 · 2012: 20
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM044589)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK45787, R01DK045787)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- peroxisome proliferation, peroxisome biogenesis, peroxisomal membrane proteins, peroxisome division, clofibrate, DEHP, tissue-specific gene expression, rats
- MeSH terms
- Peroxins, Amino Acid Sequence, Animals, Cell Line, Fungal Proteins, Humans, Membrane Proteins, Microbodies, Molecular Sequence Data, Gene Expression, Sequence Homology, Amino Acid, DNA Primers, DNA, Complementary, Fluorescent Antibody Technique, Indirect, Rats
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