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β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor
Open accessAbstract
beta-Arrestins mediate agonist-dependent desensitization of G protein-coupled receptors and target the receptors to clathrin-coated pits for internalization. Here we report an expanded role of beta-arrestins in promoting clathrin-mediated endocytosis of a tyrosine kinase growth factor receptor, i.e. the insulin-like growth factor I (IGF-1) receptor. beta-Arrestins bind to the ligand-occupied IGF-1 receptors, promote their endocytosis, and enhance IGF-1-dependent mitogen-activated protein kinase phosphorylation and DNA synthesis. Our results suggest a role for beta-arrestins in regulating mitogenic signaling and clathrin-mediated endocytosis of receptors not classically coupled to G proteins.
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Citations
Cited by
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Self-citationBeyond Desensitization: Physiological Relevance of Arrestin-Dependent Signaling
Luttrell, L. M., Gesty-Palmer, D., & Sibley, D. R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002436 · Cited by 369
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
Lefkowitz, R. J., Rajagopal, K., & Whalen, E. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.11.007 · Cited by 301
Self-citationRaehal, K. M., Schmid, C. L., Groer, C. E., & Bohn, L. M. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004598 · Cited by 256
Subcellular Organization of GPCR Signaling
Eichel, K., & von Zastrow, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.009 · Cited by 250
Metadata
- Authors
- Lin, F.-T., Daaka, Y., & Lefkowitz, R. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 273
- Issue
- 48
- Pages
- 31640-31643
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2163304919
- Cited by
- 182
- References
- 0
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor. https://app.cochat.ai/papers/10.1074/jbc.273.48.31640
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- Lin, F.-T., Daaka, Y., & Lefkowitz, R. J. (1998). β-Arrestins Regulate Mitogenic Signaling and Clathrin-mediated Endocytosis of the Insulin-like Growth Factor I Receptor. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.48.31640
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