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The Molecular Basis of Substrate Channeling
Open accessAbstract
Substrate channeling is the process of direct transfer of an intermediate between the active sites of two enzymes that catalyze sequential reactions in a biosynthetic pathway (for reviews see Refs. 1 and 2). The active sites can be located either on separate domains in a multifunctional enzyme or on separate subunits in a multienzyme complex.
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Citations
Cited by
Structural biology of proline catabolism
Tanner, J. J. (2008) · Amino Acids · doi:10.1007/s00726-008-0062-5 · Cited by 154
The advantage of channeling nucleotides for very processive functions
Zala, D., Schlattner, U., Desvignes, T., Bobe, J., Roux, A., Chavrier, P., & Boissan, M. (2017) · F1000Research · doi:10.12688/f1000research.11561.2 · Cited by 79
Enzyme co-localisation: Mechanisms and benefits
Kondrat, S., Krauss, U., & von Lieres, E. (2022) · Current Research in Chemical Biology · doi:10.1016/j.crchbi.2022.100031 · Cited by 19
Fluorescent Biosensor-Guided Engineering of Enzyme Cascades for Electrochemical Applications
Ricks, N. J., Brachi, M., Arun, F., Baiarashov, E., Minteer, S. D., & Hammond, M. C. (2026) · ACS Catalysis · doi:10.1021/acscatal.5c08170 · Cited by 2
Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase
Thach, T., Dhanabalan, K., Maurya, S., Han-Hallett, Y., Quan, S., Allison, J., Ramanathan, G., & Subramanian, R. (2026) · eLife · doi:10.7554/elife.109964
Metadata
- Authors
- Miles, E. W., Rhee, S., & Davies, D. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 274
- Issue
- 18
- Pages
- 12193-12196
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2033832729
- Cited by
- 370
- References
- 0
- FWCI
- 12.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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