The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
An Evolutionarily Conserved Family of Hsp70/Hsc70 Molecular Chaperone Regulators
Open accessAbstract
Heat Shock Protein 70 kDa (Hsp70) family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells. The mechanisms by which Hsp70 family chaperones are regulated, however, are only partly understood. BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip. We describe the identification of a family of BAG-1-related proteins from humans (BAG-2, BAG-3, BAG-4, BAG-5), the invertebrate Caenorhabditis elegans (BAG-1, BAG-2), and the fission yeast Schizosaccharomyces pombe (BAG-1A, BAG-1B). These proteins all contain a conserved approximately 45-amino acid region near their C termini (the BAG domain) that binds Hsc70/Hsp70, but they differ widely in their N-terminal domains. The human BAG-1, BAG-2, and BAG-3 proteins bind with high affinity (KD congruent with 1-10 nM) to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The findings suggest opportunities for specification and diversification of Hsp70/Hsc70 chaperone functions through interactions with various BAG-family proteins.
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Cites
Molecular chaperones in cellular protein folding
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Self-citationFolding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones
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BAG-1 modulates the chaperone activity of Hsp70/Hsc70
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Self-citationHip, a novel cochaperone involved in the eukaryotic hsc70/hsp40 reaction cycle
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Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.
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Cited by
Rosenzweig, R., Nillegoda, N. B., Mayer, M. P., & Bukau, B. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0133-3 · Cited by 1,285
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Sondermann, H., Scheufler, C., Schneider, C., Höhfeld, J., Hartl, F.-U., & Moarefi, I. (2001) · Science · doi:10.1126/science.1057268 · Cited by 435
Molecular chaperone targeting and regulation by BAG family proteins
Takayama, S., & Reed, J. C. (2001) · Nature Cell Biology · doi:10.1038/ncb1001-e237 · Cited by 400
Self-citationDemand, J., Alberti, S., Patterson, C., & Höhfeld, J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00487-0 · Cited by 377
Metadata
- Authors
- Takayama, S., Xie, Z., & Reed, J. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-01
- Volume
- 274
- Issue
- 2
- Pages
- 781-786
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2158482235
- Cited by
- 517
- References
- 34
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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