The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Polycystic Kidney Disease 1 Gene Product Modulates Wnt Signaling
Open accessAbstract
Two distinct signaling pathways, involving Wnt signaling and polycystin, have been found to be critical for normal kidney development. Renal tubulogenesis requires the presence of certain Wnt proteins, whereas mutations in polycystin impede the terminal differentiation of renal tubular epithelial cells, causing the development of large cystic kidneys that characterize autosomal dominant polycystic kidney disease. Polycystin is an integral membrane protein, consisting of several extracellular motifs indicative of cell-cell and cell-matrix interactions, coupled through multiple transmembrane domains to a functionally active cytoplasmic domain. We report here that expression of the C-terminal cytoplasmic domain of polycystin stabilizes soluble endogenous beta-catenin and stimulates TCF-dependent gene transcription in human embryonic kidney cells. Microinjection of the polycystin C-terminal cytoplasmic domain induces dorsalization in zebrafish. Our findings suggest that polycystin has the capacity to modulate Wnt signaling during renal development.
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Cites
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Cited by
Autosomal dominant polycystic kidney disease
Torres, V. E., Harris, P. C., & Pirson, Y. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60601-1 · Cited by 1,550
Wilson, P. D. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022161 · Cited by 916
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Self-citationGenetics and Pathogenesis of Polycystic Kidney Disease
Igarashi, P., & Somlo, S. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000028643.17901.42 · Cited by 593
A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
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Metadata
- Authors
- Kim, E., Arnould, T., Sellin, L. K., Benzing, T., Fan, M. J., Grüning, W., Sokol, S. Y., Drummond, I., & Walz, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-02
- Volume
- 274
- Issue
- 8
- Pages
- 4947-4953
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1969887954
- Cited by
- 271
- References
- 39
- FWCI
- 11.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kim, E., Arnould, T., Sellin, L. K., Benzing, T., Fan, M. J., Grüning, W., Sokol, S. Y., Drummond, I., & Walz, G. (1999). The Polycystic Kidney Disease 1 Gene Product Modulates Wnt Signaling. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.8.4947
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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