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DNA Polymerase β-mediated Long Patch Base Excision Repair
Open accessAbstract
Recently, photoaffinity labeling experiments with mouse cell extracts suggested that PARP-1 functions as a surveillance protein for a stalled BER intermediate. To further understand the role of PARP-1 in BER, we examined the DNA synthesis and flap excision steps in long patch BER using a reconstituted system containing a 34-base pair BER substrate and five purified human enzymes: uracil-DNA glycosylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap endonuclease-1 (FEN-1), and PARP-1. PARP-1 stimulates strand displacement DNA synthesis by DNA polymerase beta in this system; this stimulation is dependent on the presence of FEN-1. PARP-1 and FEN-1, therefore, cooperate to activate long patch BER. The results are discussed in the context of a model for BER sub-pathway choice, illustrating a dual role for PARP-1 as a surveillance protein for a stalled BER intermediate and an activating factor for long patch BER DNA synthesis.
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Citations
Cites
Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair
Matsumoto, Y., & Kim, K. (1995) · Science · doi:10.1126/science.7624801 · Cited by 683
Fortini, P., Pascucci, B., Parlanti, E., Sobol, R. W., Wilson, S. H., & Dogliotti, E. (1998) · Biochemistry · doi:10.1021/bi972999h · Cited by 232
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Cited by
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Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
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Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727
El-Khamisy, S. F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg761 · Cited by 659
Bernstein, C. (2002) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(02)00009-1 · Cited by 527
Vidal, A. E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6530 · Cited by 458
Metadata
- Authors
- Prasad, R., Lavrik, O. I., Kim, S.-J., Kedar, P., Yang, X.-P., Vande Berg, B. J., & Wilson, S. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 276
- Issue
- 35
- Pages
- 32411-32414
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1967634425
- Cited by
- 198
- References
- 2
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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