The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Functional Embryonic Cardiomyocytes after Disruption of the L-type α1C (Ca 1.2) Calcium Channel Gene in the Mouse
Open accessAbstract
The L-type alpha(1C) (Ca(v)1.2) calcium channel is the major calcium entry pathway in cardiac and smooth muscle. We inactivated the Ca(v)1.2 gene in two independent mouse lines that had indistinguishable phenotypes. Homozygous knockout embryos (Ca(v)1. 2-/-) died before day 14.5 postcoitum (p.c.). At day 12.5 p.c., the embryonic heart contracted with identical frequency in wild type (+/+), heterozygous (+/-), and homozygous (-/-) Ca(v)1.2 embryos. Beating of isolated embryonic cardiomyocytes depended on extracellular calcium and was blocked by 1 microm nisoldipine. In (+/+), (+/-), and (-/-) cardiomyocytes, an L-type Ba(2+) inward current (I(Ba)) was present that was stimulated by Bay K 8644 in all genotypes. At a holding potential of -80 mV, nisoldipine blocked I(Ba) of day 12.5 p.c. (+/+) and (+/-) cells with two IC(50) values of approximately 0.1 and approximately 1 microm. Inhibition of I(Ba) of (-/-) cardiomyocytes was monophasic with an IC(50) of approximately 1 microm. The low affinity I(Ba) was also present in cardiomyocytes of homozygous alpha(1D) (Ca(v)1.3) knockout embryos at day 12.5 p.c. These results indicate that, up to day 14 p.c., contraction of murine embryonic hearts requires an unidentified, low affinity L-type like calcium channel.
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Cites
Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels
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Self-citationPrimary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel
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An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness
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Ion Channels and Synaptic Organization
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MOLECULAR DETERMINANTS OF DRUG BINDING AND ACTION ON L-TYPE CALCIUM CHANNELS
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Self-citationStructural basis of drug binding to L Ca2+ channels
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Observational fear learning involves affective pain system and Cav1.2 Ca2+ channels in ACC
Jeon, D., Kim, S., Chetana, M., Jo, D., Ruley, H. E., Lin, S.-Y., Rabah, D., Kinet, J.-P., & Shin, H.-S. (2010) · Nature Neuroscience · doi:10.1038/nn.2504 · Cited by 651
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Metadata
- Authors
- Seisenberger, C., Specht, V., Welling, A., Platzer, J., Pfeifer, A., Kühbandner, S., Striessnig, J., Klugbauer, N., Feil, R., & Hofmann, F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-12
- Volume
- 275
- Issue
- 50
- Pages
- 39193-39199
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1998672281
- Cited by
- 269
- References
- 25
- FWCI
- 6.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Functional Embryonic Cardiomyocytes after Disruption of the L-type α1C (Ca 1.2) Calcium Channel Gene in the Mouse. https://app.cochat.ai/papers/10.1074/jbc.m006467200
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- Seisenberger, C., Specht, V., Welling, A., Platzer, J., Pfeifer, A., Kühbandner, S., Striessnig, J., Klugbauer, N., Feil, R., & Hofmann, F. (2000). Functional Embryonic Cardiomyocytes after Disruption of the L-type α1C (Ca 1.2) Calcium Channel Gene in the Mouse. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m006467200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
