Cited by 282Lipid metabolism and biosynthesisCancer, Lipids, and MetabolismPeroxisome Proliferator-Activated Receptors

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Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats

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Luiken, Joost J.F.P., Arumugam, Yoga, Dyck, David J., Bell, Rhonda C., Pelsers, Maurice M.L., Turcotte, Lorraine P., Tandon, Narendra N., Glatz, Jan F.C., Bonen, Arend·2001·Journal of Biological Chemistry

DOI 10.1074/jbc.m100052200

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Abstract

Giant vesicles were used to study the rates of uptake of long-chain fatty acids by heart, skeletal muscle, and adipose tissue of obese and lean Zucker rats. With obesity there was an increase in vesicular fatty acid uptake of 1.8-fold in heart, muscle and adipose tissue. In some tissues only fatty acid translocase (FAT) mRNA (heart, +37%; adipose, +80%) and fatty acid-binding protein (FABPpm) mRNA (heart, +148%; adipose, +196%) were increased. At the protein level FABPpm expression was not changed in any tissues except muscle (+14%), and FAT/CD36 protein content was altered slightly in adipose tissue (+26%). In marked contrast, the plasma membrane FAT/CD36 protein was increased in heart (+60%), muscle (+80%), and adipose tissue (+50%). The plasma membrane FABPpm was altered only in heart (+50%) and adipose tissues (+70%). Thus, in obesity, alterations in fatty acid transport in metabolically important tissues are not associated with changes in fatty acid transporter mRNAs or altered fatty acid transport protein expression but with their increased abundance at the plasma membrane. We speculate that in obesity fatty acid transporters are relocated from an intracellular pool to the plasma membrane in heart, muscle, and adipose tissues.

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“, 2015), which ultimately supports increased fatty acid uptake into both skeletal muscle (Luiken et al., 2001; Bonen et al., 2004; Han et al., 2007; Holloway et al., 2008) and liver (Westerbacka et al.”
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Authors: Luiken, J. J. F. P., Arumugam, Y., Dyck, D. J., Bell, R. C., Pelsers, M. M. L., Turcotte, L. P., Tandon, N. N., Glatz, J. F. C., & Bonen, A.
Affiliations: University of Waterloo (CA)
University of Guelph (CA)
University of Alberta (CA)
University of Southern California (US)
Maastricht University (NL)
Corresponding author: Bonen, Arend
ORCID: Luiken, Joost J.F.P.
Dyck, David J.
Bell, Rhonda C.
Turcotte, Lorraine P.
Glatz, Jan F.C.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2001-11
Volume: 276
Issue: 44
Pages: 40567-40573
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m100052200
OpenAlex: W2069262764
Cited by: 282
References: 42
Citations by year: 2026: 1 · 2025: 4 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 17 · 2020: 10 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 14 · 2012: 14
FWCI: 8.37
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 6909 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29ar045168-04)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 45168)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: fatty acid uptake, obesity, Zucker rats, fatty acid translocase, FAT/CD36, fatty acid binding protein, plasma membrane localization, heart, skeletal muscle, adipose tissue, vesicular uptake
MeSH terms: Animals, Fatty Acids, Female, Kinetics, Membrane Glycoproteins, Obesity, Rats, Zucker, RNA, Messenger, CD36 Antigens, Organic Anion Transporters, Rats

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Increased Rates of Fatty Acid Uptake and Plasmalemmal Fatty Acid Transporters in Obese Zucker Rats

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