The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Expression of Serotonin Receptors in Bone
Open accessAbstract
The 5-hydroxytryptamine (5-HT) receptors 5-HT(2A), 5-HT(2B), and 5-HT(2C) belong to a subfamily of serotonin receptors. Amino acid and mRNA sequences of these receptors have been published for several species including man. The 5-HT(2) receptors have been reported to act on nervous, muscle, and endothelial tissues. Here we report the presence of 5-HT(2B) receptor in fetal chicken bone cells. 5-HT(2B) receptor mRNA expression was demonstrated in osteocytes, osteoblasts, and periosteal fibroblasts, a population containing osteoblast precursor cells. Pharmacological studies using several agonists and antagonists showed that occupancy of the 5-HT(2B) receptor stimulates the proliferation of periosteal fibroblasts. Activity of the 5-HT(2A) receptor could however not be excluded. mRNA for both receptors was shown to be equally present in adult mouse osteoblasts. Osteocytes, which showed the highest expression of 5-HT(2B) receptor mRNA in chicken, and to a lesser extent osteoblasts, are considered to be mechanosensor cells involved in the adaptation of bone to its mechanical usage. Nitric oxide is one of the signaling molecules that is released upon mechanical stimulation of osteocytes and osteoblasts. The serotonin analog alpha-methyl-5-HT, which preferentially binds to 5-HT(2) receptors, decreased nitric oxide release by mechanically stimulated mouse osteoblasts. These results demonstrate that serotonin is involved in bone metabolism and its mechanoregulation.
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Cites
Kleinnulend, J., Semeins, C. M., Ajubi, N. E., Nijweide, P. J., & Burger, E. H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2822 · Cited by 425
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Cited by
Weaver, C. M., Gordon, C. M., Janz, K. F., Kalkwarf, H. J., Lappe, J. M., Lewis, R., O’Karma, M., Wallace, T. C., & Zemel, B. S. (2016) · Osteoporosis International · doi:10.1007/s00198-015-3440-3 · Cited by 1,378
Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture
Richards, J. B. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.2.188 · Cited by 386
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Ahlawat, S., Asha, & Sharma, K. K. (2021) · Letters in Applied Microbiology · doi:10.1111/lam.13333 · Cited by 361
Bone and muscle: Interactions beyond mechanical
Brotto, M., & Bonewald, L. (2015) · Bone · doi:10.1016/j.bone.2015.02.010 · Cited by 351
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Chrcanovic, B. R., Kisch, J., Albrektsson, T., & Wennerberg, A. (2016) · Journal of Dental Research · doi:10.1177/0022034516646098 · Cited by 286
Metadata
- Authors
- Westbroek, I., van der Plas, A., de Rooij, K. E., Klein-Nulend, J., & Nijweide, P. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 276
- Issue
- 31
- Pages
- 28961-28968
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2168347208
- Cited by
- 206
- References
- 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Westbroek, I., van der Plas, A., de Rooij, K. E., Klein-Nulend, J., & Nijweide, P. J. (2001). Expression of Serotonin Receptors in Bone. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m101824200
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
