Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53

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  3. PTEN Regulates Mdm2 Expression through the P1 Promoter
    Chun-Ju Chang, Daniel J. Freeman, Hong Wu · 2004 · Journal of Biological Chemistry
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    Austin Young Shull, Alicia Latham-Schwark, Poornema Ramasamy, Kristin L. Leskoske, Dora Oroian, Marc R. Birtwistle, Phillip Buckhaults · 2012 · PLoS ONE
  7. Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt–Mdm2–p53 pathway
    Kenneth R. Rogulski, Youjun Li, Kristi D. Rothermund, Lixia Pu, Simon C. Watkins, Fenghua Yi, Edward V. Prochownik · 2005 · Oncogene
  8. Caveolin and cavin family members: Dual roles in cancer
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  9. Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells
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  10. TIGAR, TIGAR, burning bright
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    Shinozaki, Tomomi, Nota, Ayumi, Taya, Yoichi, Okamoto, Koji · 2003 · Oncogene
  12. Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs
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  15. Roles of the PI3K/Akt pathway and autophagy in TLR3 signaling-induced apoptosis and growth arrest of human prostate cancer cells
    Nanae Harashima, Tohko Inao, Ryu Imamura, Shinji Okano, Takashi Suda, Mamoru Harada · 2011 · Cancer Immunology Immunotherapy
  16. The Inhibitory Mechanisms of Tumor PD-L1 Expression by Natural Bioactive Gallic Acid in Non-Small-Cell Lung Cancer (NSCLC) Cells
    Dong Young Kang, Nipin Sp, Eun Seong Jo, Alexis Rugamba, Dae Young Hong, Mark Hong Lee, Ji‐Seung Yoo, Qing Liu, Kyoung‐Jin Jang, Young Mok Yang · 2020 · Cancers
  17. Elevated Levels of Oncogenic Protein Kinase Pim-1 Induce the p53 Pathway in Cultured Cells and Correlate with Increased Mdm2 in Mantle Cell Lymphoma
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  18. DNA Damage–Induced Protein 14-3-3 σ Inhibits Protein Kinase B/Akt Activation and Suppresses Akt-Activated Cancer
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  19. A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis
    Virginie Olive, Erich Y. Sabio, Margaux J. Bennett, Caitlin S De Jong, Anne Biton, James C. McGann, Samantha K. Greaney, Nicole M. Sodir, Alicia Yiran Zhou, Asha Balakrishnan et al. · 2013 · eLife
  20. Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells
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  21. SCF E3 ligase F‐box protein complex SCF FBXL19 regulates cell migration by mediating Rac1 ubiquitination and degradation
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  22. Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation
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  23. Phosphorylation of MDMX Mediated by Akt Leads to Stabilization and Induces 14-3-3 Binding
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  24. TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression
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  25. SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival
    Nina Fenouille, Alexandre Puissant, Mélanie Tichet, Geordie Zimniak, Patricia Abbe, Aude Mallavialle, Stéphane Rocchi, J.‐P. Ortonne, Marcel Deckert, Robert Ballotti et al. · 2011 · Oncogene
  26. p53 Is a Key Molecular Target of Ursodeoxycholic Acid in Regulating Apoptosis
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  27. Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway
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  28. p53 protects against LPS-induced lung endothelial barrier dysfunction
    Nektarios Barabutis, Christiana Dimitropoulou, Charalampos Birmpas, Atul Joshi, Gagan Singh Thangjam, John D. Catravas · 2015 · American Journal of Physiology-Lung Cellular and Molecular Physiology
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  30. BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions
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  31. The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation
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  32. Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells
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  33. The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells
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  34. Apoptosis in Parkinson's disease: Is p53 the missing link between genetic and sporadic Parkinsonism?
    Cristine Alvès da Costa, Frédéric Checler · 2010 · Cellular Signalling
  35. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6
    Emilie Giaime, Claire Sunyach, Charlotte Druon, Sabine Scarzello, Guillaume Robert, Sébastien Grosso, Patrick Auberger, Matthew S. Goldberg, Jie Shen, Peter Heutink et al. · 2009 · Cell Death and Differentiation
  36. The prognostic value of PTEN, p53, and beta-catenin in endometrial carcinoma: a prospective immunocytochemical study
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  37. Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway
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  38. MEK-ERK-mediated Phosphorylation of Mdm2 at Ser-166 in Hepatocytes
    Maria Malmlöf, Emilie Annie Roudier, Johan Högberg, Ulla Stenius · 2006 · Journal of Biological Chemistry
  39. Activation of LKB1-Akt Pathway Independent of Phosphoinositide 3-Kinase Plays a Critical Role in the Proliferation of Hepatocellular Carcinoma From Nonalcoholic Steatohepatitis
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  40. IL-1 and EGF regulate expression of genes important in inflammation and cancer
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  41. Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment
    Bodo Clemens Melnik · 2023 · Cells
  42. MDM2 Is Required for Suppression of Apoptosis by Activated Akt1 in Salivary Acinar Cells
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  43. MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 IS ACTIVATED IN RESPONSE TO INHIBITED Akt SIGNALING.
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  44. A genome‐wide si RNA screen for regulators of tumor suppressor p53 activity in human non‐small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment
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  45. AP-1 Regulates Cyclin D1 and c-MYC Transcription in an AKT-Dependent Manner in Response to mTOR Inhibition: Role of AIP4/Itch-Mediated JUNB Degradation
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  46. F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress
    Sunil Kumar Malonia, Parul Dutta, Manas Kumar Santra, Michael R. Green · 2015 · Proceedings of the National Academy of Sciences
  47. MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome
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  48. The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide
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  49. Pten Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific Manner
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  50. Inhibition of β-TrcP–dependent ubiquitination of p53 by HIV-1 Vpu promotes p53–mediated apoptosis in human T cells
    Sachin Kumar Verma, Amjad Ali, Sakshi Arora, Akhil Chandra Banerjea · 2011 · Blood
  51. Pathological Signaling via Platelet-Derived Growth Factor Receptor α Involves Chronic Activation of Akt and Suppression of p53
    Hetian Lei, Gisela Velez, Andrius Kazlauskas · 2011 · Molecular and Cellular Biology
  52. Mechanistic elements and critical factors of cellular reprogramming revealed by stepwise global gene expression analyses
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  53. The Many Faces of MDM2 Binding Partners
    Maurisa F. Riley, Guillermina Lozano · 2012 · Genes & Cancer
  54. Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
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  55. ZNF677 Suppresses Akt Phosphorylation and Tumorigenesis in Thyroid Cancer
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  56. Taming the PI3K team to hold inflammation and cancer at bay
    Emilio Hirsch, Elisa Ciraolo, Alessandra Ghigo, Carlotta Costa · 2008 · Pharmacology & Therapeutics
  57. Mechanisms of Activation and Regulation of the Heat Shock-Sensitive Signaling Pathways
    Sébastien Ian Nadeau, Jacques Landry · 2007 · Springer eBooks
  58. p53 in the CNS: Perspectives on Development, Stem Cells, and Cancer
    Susan M. Mendrysa, Sara Ghassemifar, Reem A. Malek · 2011 · Genes & Cancer
  59. AKT‐dependent phosphorylation of Niban regulates nucleophosmin‐ and MDM2‐mediated p53 stability and cell apoptosis
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  60. Postconditioning by Volatile Anesthetics: Salvaging Ischemic Myocardium at Reperfusion by Activation of Prosurvival Signaling
    Paul S. Pagel · 2008 · Journal of Cardiothoracic and Vascular Anesthesia
  61. Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo
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  62. Mdm2 in growth signaling and cancer
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  63. Apoptosis Inhibitor ARC Promotes Breast Tumorigenesis, Metastasis, and Chemoresistance
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  67. p53 and Notch signaling in chronic lymphocytic leukemia: clues to identifying novel therapeutic strategies
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  69. Shikonin Inhibits Thyroid Cancer Cell Growth and Invasiveness Through Targeting Major Signaling Pathways
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  71. Tied Up in Loops: Positive and Negative Autoregulation of p53
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  77. p53 ubiquitination by Mdm2: A never ending tail?
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  80. Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II
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