Substoichiometric Levels of Cu2+ Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

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Items 101–159 of 159

1. Divalent copper ion bound amyloid-β(40) and amyloid-β(42) alloforms are less preferred than divalent zinc ion bound amyloid-β(40) and amyloid-β(42) alloforms
   Orkid Coskuner‐Weber · 2016 · JBIC Journal of Biological Inorganic Chemistry
2. Copper(ii) and zinc(ii) dependent effects on Aβ42 aggregation: a CD, Th-T and SFM study
   Francesco Attanasio, Paolo De Bona, Sebastiano Cataldo, Michele F. M. Sciacca, Danilo Milardi, Bruno Pignataro, Giuseppe Pappalardo · 2013 · New Journal of Chemistry
3. Optimization of mechanical and antibacterial properties of SLM–fabricated TC4–5Cu alloy by annealing heat treatment
   Wen-Xin Yang, Ying Chen, Lin Yang, Shang Zhu, Yifeng Wang, Yu-Sheng Shi · 2023 · Journal of Alloys and Compounds
4. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models
   Michele F. M. Sciacca, Налетова Ирина Николаевна, Maria Laura Giuffrida, Francesco Attanasio · 2022 · ACS Chemical Neuroscience
5. Cu2+ Affects Amyloid-\b{eta} (1-42) Aggregation by Increasing Peptide-Peptide Binding Forces
   Francis T. Hane, Gary Tran, Simon J. Attwood, Zoya Leonenko · 2017 · arXiv (Cornell University)
6. From Small Peptides to Large Proteins against Alzheimer’sDisease
   Pasquale Picone, Tiziana Sanfilippo, Sonya Vasto, Sara Baldassano, Rossella Guggino, Domenico Nuzzo, Donatella Bulone, Pier Luigi San Biagio, Emanuela Muscolino, Roberto Monastero et al. · 2022 · Biomolecules
7. Functional characterization of copper transporters zCtr1, zAtox1, zAtp7a and zAtp7b in zebrafish liver cell line ZFL.
   Man-Long Kwok, King M. Chan · 2019 · Metallomics
8. Inhibitory effect of human serum albumin on Cu-induced Aβ40 aggregation and toxicity
   Naihao Lu, Qin Yang, Jiayu Li, Rong Tian, Yiyuan Peng · 2015 · European Journal of Pharmacology
9. Proteomic Analysis of the Copper Ion-Induced Stress Response in a Human Embryonic Carcinoma Cell Line
   D. Han, Mi-Ran Choi, K. Jung, Hyung Tae Lee, J. H. Park, T. Ohn, Y. Chai · 2012 · International journal of toxicology
10. CdSe/ZnS core/shell quantum dots as luminescence lifetime sensors for Cu2+
    J. Sutter, D. Birch, O. Rolinski · 2012
11. Copper-mediated growth of amyloid β fibrils in the presence of oxidized and negatively charged liposomes.
    T. Shimanouchi, Ryo Onishi, Nachi Kitaura, H. Umakoshi, R. Kuboi · 2011 · Journal of Bioscience and Bioengineering
12. Copper overload worsens the inflammatory response of microglia to amyloid beta (Aβ) by impairing phagocytosis and promoting mitochondrial DNA-mediated NLRP3 inflammasome activation
    Marlene Zubillaga, Xenia Abadin, Elia Ivars, Margalida Puigròs, Ramón Trullás, María José Bellini, Nathalie Arnal, Anna Colell · 2025 · Redox Biology
13. Cross-seeding of WT amyloid-β with Arctic but not Italian familial mutants accelerates fibril formation in Alzheimer's disease
    Ruina Liang, Yao Tian, John H. Viles · 2022 · Journal of Biological Chemistry
14. Electrochemical Amyloid-Based Biosensor for the Determination of Metal Ions
    Joohyung Park, Wonseok Lee, Gyudo Lee, Hyunsung Choi, Minwoo Kim, Woong Kim, Sungsoo Na, Jinsung Park · 2019 · Journal of the Electrochemical Society
15. Reciprocal modulation of Aβ42 aggregation by copper and homocysteine
    Salla Keskitalo, Melinda Farkas, Michael Hanenberg, Anita Szodorai, Luka Kulic, Alexander Semmler, Michael Weller, Roger M. Nitsch, Michael Linnebank · 2014 · Frontiers in Aging Neuroscience
16. Calcium channel blockers’ contribution to overcoming Current drug discovery challenges in Alzheimer’s disease
    Paul J. Bernard, Djamila Bellili, Lhassane Ismaïli · 2023 · Expert Opinion on Drug Discovery
17. Effect of Metals on Kinetic Pathways of Amyloid-\b{eta} Aggregation
    Francis Hane, Z. Leonenko · 2017
18. Aging-Related Protein Alterations in the Brain
    Rafay Ali Syed, Mahnoor Hayat, Hammad Qaiser, Mohammad Uzair, Khalid Al-Regaiey, Roaa A. Khallaf, Imdad Kaleem, Shahid Bashir · 2024 · Journal of Alzheimer s Disease
19. Key roles of Tyr 10 in Cu bound Aβ complexes and its relevance to Alzheimer's disease
    Naihao Lu, Jiayu Li, Zhonghong Gao · 2015 · Archives of Biochemistry and Biophysics
20. Interaction of Metal Ions with the His13-His14 Sequence Relevant to Alzheimer’s Disease
    Xiangtao Kong, Zhi Zhao, Xin Lei, 张冰冰, Dongxu Dai, Ling Jiang · 2015 · The Journal of Physical Chemistry A
21. Molecular dynamics simulations of copper binding to amyloid-β Glu22 mutants
    Shaun T. Mutter, Matthew Turner, Robert James Deeth, James A. Platts · 2019 · Heliyon
22. Big versus small: The impact of aggregate size in disease
    Brianna Hnath, Jiaxing Chen, Joshua Reynolds, Esther Sue Choi, Jian Wang, Dongyan Zhang, Congzhou Mike Sha, Nikolay V. Dokholyan · 2023 · Protein Science
23. Evidence for a central role of PrP helix 2 in the nucleation of amyloid fibrils
    Ryo P. Honda, Kazuo Kuwata · 2018 · The FASEB Journal
24. Curcumin induces structural change and reduces the growth of amyloid-β fibrils: a QCM-D study
    Cong-Gang Wang, Li Xu, Fang Cheng, Han-Qi Wang, Lingyun Jia · 2015 · RSC Advances
25. An N-terminal acidic β-sheet domain is responsible for the metal-accumulation properties of amyloid-β protofibrils: a molecular dynamics study
    Carlos Zepactonal Gómez-Castro, Liliana Quintanar, Alberto Vela · 2024 · JBIC Journal of Biological Inorganic Chemistry
26. Revisiting Cu(II) Bound Amyloid-β40 and Amyloid-β42 Peptides: Varying Coordination Chemistries
    Orkid Coskuner‐Weber · 2018 · Journal of the Turkish Chemical Society Section A Chemistry
27. Covalent modifications of the amyloid beta peptide by hydroxynonenal: Effects on metal ion binding by monomers and insights into the fibril topology
    Giuseppe Grasso, Hiroaki Komatsu, Paul H. Axelsen · 2017 · Journal of Inorganic Biochemistry
28. Elevated copper ion levels as potential cause of impaired kinesin-dependent transport processes
    K. Böhm · 2015 · Archives of Toxicology
29. Side Effect of Tris on the Interaction of Amyloid β-peptide with Cu2+: Evidence for Tris–Aβ–Cu2+ Ternary Complex Formation
    Yannan Bin, Zhongxiu Jiang, Juan Xiang · 2015 · Applied Biochemistry and Biotechnology
30. The co-effect of copper and lipid vesicles on Aβ aggregation
    Xuehang Zhu, Wenjing Liu, Weijing Zhao, Ziwei Chang, Jun Yang · 2022 · Biochimica et Biophysica Acta (BBA) - Biomembranes
31. Interactions between copper (II) and β-amyloid peptide using capillary electrophoresis–ICP–MS: Kd measurements at the nanogram scale
    Coraline Duroux, Agnès Hagège · 2021 · Analytical and Bioanalytical Chemistry
32. Copper(II) partially protects three histidine residues and the N‐terminus of amyloid‐β peptide from diethyl pyrocarbonate (DEPC) modification
    Merlin Friedemann, V. Tõugu, P. Palumaa · 2020 · FEBS Open Bio
33. Aqueous Synthesis of Protein-Encapsulated ZnSe Quantum Dots and Physical Significance of Semiconductor-Induced CuII Ion Sensing.
    Somashree Kundu, S. Maiti, D. Ghosh, C. N. Roy, A. Saha · 2017 · ChemPhysChem
34. Copper in Wilson’s and Alzheimer’s Diseases, Copper-Lowering Therapy in Cancer and Other Diseases, and Copper Deficiency
    George J. Brewer · 2016 · Elsevier eBooks
35. Copper interaction with cystatin C: effects on protein structure and oligomerization
    Justyna Żygowska, Marta Orlikowska, Igor Zhukov, Wojciech Bal, Aneta Szymańska · 2024 · FEBS Journal
36. Unravelling the complex interplay of cuproptosis, lncRNAs, and immune infiltration in Alzheimer’s disease: a step towards novel therapeutic targets
    Yi Zeng, Siqi Qian, Yuan Cao, Wen-Biao Xiao · 2024 · Annals of Human Biology
37. Ligand steric effects of nano-inhibitors on Aβ fibrillation at the nano-bio interfaces
    Bin Zhang, Guanbin Gao, Zijun Zhang, Baisheng Cao, Taolei Sun · 2023 · Applied Surface Science
38. An Electrochemistry and Computational Study at an Electrified Liquid–Liquid Interface for Studying Beta-Amyloid Aggregation
    Bongiwe Silwane, Mark Richard Wilson, Ritu Kataky · 2023 · Membranes
39. Synthesis and characterization of 8-aminoquinolines, substituted by electron donating groups, as high-affinity copper chelators for the treatment of Alzheimer's disease
    Ju Huang, M. Nguyen, Yan Liu, A. Robert, B. Meunier · 2019 · Comptes rendus. Chimie
40. Cofactor-mediated amyloidogenesis
    J. Madine · 2019 · Bioscience Reports
41. Cytogenetic Analysis and Screening of ApoE and Neurotransmitters in Alzheimer’s Patients in Tamil Nadu Population
    K. Sasikalaa, S. Sureshkumar, B. Balamuralikrishnana, M. Aruna, A. Karthickkumar, A. Ahmad, K. Sankar, V. Dhivya, N. Srilakshmiprabha, S. Devi et al. · 2016
42. Exploring the neuroprotective, antioxidant, and anti-amyloid effects of Ganoderma lucidum compounds in Alzheimer’s disease: insights from experimental and computational approaches
    Mojnu Mia, Amit Dutta, Md. Mainuddin Hossain, Juthi Adhikari, Md. Masuder Rahman, Abu Zaffar Shibly · 2026 · Journal of Genetic Engineering and Biotechnology
43. Guluronic acid disaccharide inhibits reactive oxygen species production and amyloid-β oligomer formation
    Hangyu Shen, Wenhui Liu, Yun Dou, Yongxin Lu, Chunling Zhang, Xiaoying Wang, Fangong Kong, Shoujuan Wang · 2024 · Biochemical and Biophysical Research Communications
44. A computational study of metal ions interaction with amyloid-β 1–42 peptide structure in hyperpyrexia: Implications for Alzheimer disease
    Cosmin Stefan Mocanu, Laura Darie‐Ion, Brîndușa Alina Petre, Vasile Robert Grădinaru, Gabi Drochioiu · 2022 · Journal of King Saud University - Science
45. Synthesis of isoniazid-substituted tetraphenylethylene stereoisomers with dramatic differences on aggregate morphologies, optical and mechanocharomic properties
    Zhixiang Lu, Shuhan Lu, Yi Cheng, Yu Qin, Shao-Xiong Yang, Xiaolan Liu, W. Fan, Li-Yan Zheng, Hongbin Zhang · 2020
46. Dityrosine cross-link trapping of amyloid-β intermediates reveals that self-assembly is required for Aβ-induced cytotoxicity
    Mahmoud Bukar Maina, Kurtis Mengham, Gunasekhar Burra, Youssra K Al-Hilaly, L. Serpell · 2020 · bioRxiv
47. Ultraviolet irradiation-mediated formation of Aβ 42 oligomers and reactive oxygen species in Zn 2+ -bound Aβ 42 aggregates irrespective of the removal of Zn 2+
    Xiang Li, Xiongwei Dong, Yaojing Liu, Yan Meng, Yong Zhang, Dan Zhang, Changlin Liu · 2016 · New Journal of Chemistry
48. Antioxidant promotion of tyrosine nitration in the presence of copper(ii)
    Liang Qiao, Baohong Liu, Hubert H. Girault · 2013 · Metallomics
49. DeepKa Protein pKa Database: Identifying pH Dependence in the Protein Data Bank.
    Bao-Rong Yang, Xiang-Xiang Lu, Zhi-Tao Cai, Jia-Wen Sun, Yan-Dong Huang · 2026 · Journal of Chemical Information and Modeling
50. Cell type transcriptomic modules reveal shared molecular mechanisms in Alzheimer’s and Parkinson’s disease
    Anwesha Bhattacharya, Edward A. Fon, Alain Dagher, Yasser Iturria‐Medina, Jo Anne Stratton, Chloé Savignac, Jack Stanley, L. M. Hodgson, Badr Ait Hammou, David A. A Bennett et al. · 2026 · GigaScience
51. Biomimetic red blood cell membrane-coated cerium metal-organic framework for multi-target synergistic therapy of Alzheimer's disease.
    Fengmei Yang, Yutong Chen, Yujiao Yan, Ruixin Zhao, Liran Deng, Die Tian, Meng Xie · 2026 · Colloids and Surfaces B: Biointerfaces
52. NMR probing of copper–amyloid β1–16 interactions and self-assembly
    Punnepalli Sunanda, S. Raghothama, Uma Maheswari Devi Palempalli, Bankala Krishnarjuna · 2024 · Academia Biology
53. Binding of Cu2+ to Aβ1-29 causes aggregation and toxicity in SH-SY5Y cells
    Masanari Taniguchi, Mayu Saito, Takahisa Kuga, Nobuyuki Yamagishi · 2020 · Biochemical and Biophysical Research Communications
54. Candidate Environmental Factors for the Alzheimer’s Epidemic Part 1
    George J. Brewer · 2018 · Elsevier eBooks
55. Metabolic cell death networks in Alzheimer’s disease: mechanistic links and therapeutic perspectives of ferroptosis, cuproptosis, and disulfidptosis
    Shuyu Ding, Zihan Guo, Hang Ji, Jinting He · 2026 · Frontiers in Cell and Developmental Biology
56. From the classical colloidal theory to biomolecular condensation: implications in health and disease
    Noelia A. Melian, Aldana Gomez, Milagros B. Abate, Pamela L. Toledo, M. Ermácora, D. S. Vazquez · 2026 · Frontiers in Biophysics
57. Protective or Deteriorative Effect of Zinc Ions on Protein Misfolding: A New Insight into Amyloidogenic Disease
    Sepideh Noorzadeh, Mohammad Reza Dayer, Saeed Aminzadeh · 2017 · Jentashapir Journal of Health Research
58. The Amyloid _-Protein and Alzheimer's Disease
    David B. Teplow, Mingfeng Yang, Robin Roychaudhuri, Eric S. Pang, Tien‐Phat V. Huynh, Mei‐Sha Chen, Shiela Beroukhim · 2012 · Frontiers in neuroscience
59. The Copper Hypothesis Fits Nicely With Known Risk Factors and Theories of Alzheimer’s Disease Causation
    G. Brewer · 2018