The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Heterotrimeric Gi Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration
Open accessAbstract
Evidence supporting the functionality of Smoothened (SMO), an essential transducer in most pathways engaged by Hedgehog (Hh), as a G(i)-coupled receptor contrasts with the lack of an apparently consistent requirement for G(i) in Hh signal transduction. In the present study, we sought to evaluate the role of SMO-G(i) coupling in fibroblast migration induced by Sonic Hedgehog (Shh). Our results demonstrate an absolute requirement for G(i) in Shh-induced fibroblast migration. We found that Shh acutely stimulates the small Rho GTPases Rac1 and RhoA via SMO through a G(i) protein- and PI3K-dependent mechanism, and that these are required for cell migration. These responses were independent of transcription by Gli and of the C-terminal domain of SMO, as we show using a combination of molecular and genetic tools. Our findings provide a mechanistic model for fibroblast migration in response to Shh and underscore the role of SMO-G(i) coupling in non-canonical Hh signaling.
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Cites
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science · doi:10.1126/science.1139740 · Cited by 1,426
Cited by
A highlight on Sonic hedgehog pathway
Carballo, G. B., Honorato, J. R., de Lopes, G. P. F., & Spohr, T. C. L. D. S. E. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0220-7 · Cited by 460
The Hedgehog Signal Transduction Network
Robbins, D. J., Fei, D. L., & Riobo, N. A. (2012) · Science Signaling · doi:10.1126/scisignal.2002906 · Cited by 419
Self-citationHedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat
Teperino, R., Amann, S., Bayer, M., McGee, S. L., Loipetzberger, A., Connor, T., Jaeger, C., Kammerer, B., Winter, L., Wiche, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.021 · Cited by 283
Yuan, X., Cao, J., He, X., Serra, R., Qu, J., Cao, X., & Yang, S. (2016) · Nature Communications · doi:10.1038/ncomms11024 · Cited by 122
Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation
Dutzmann, J., Koch, A., Weisheit, S., Sonnenschein, K., Korte, L., Haertlé, M., Thum, T., Bauersachs, J., Sedding, D. G., & Daniel, J.-M. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx158 · Cited by 49
Metadata
- Authors
- Polizio, A. H., Chinchilla, P., Chen, X., Kim, S., Manning, D. R., & Riobo, N. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 286
- Issue
- 22
- Pages
- 19589-19596
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2011815295
- Cited by
- 159
- References
- 2
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Heterotrimeric Gi Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration. https://app.cochat.ai/papers/10.1074/jbc.m110.197111
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- Polizio, A. H., Chinchilla, P., Chen, X., Kim, S., Manning, D. R., & Riobo, N. A. (2011). Heterotrimeric Gi Proteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m110.197111
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