Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain

Background: Hsp90 binds to functional domains of protein clients, including the ligand-binding domain of the aryl hydrocarbon receptor (AhR). Results: Hsp90- and ligand-binding sites spatially overlap, and ligand displaces Hsp90 in AhR activation. Conclusion: Hsp90 binding affects AhR activation …