Nitric Oxide Suppresses Tumor Cell Migration through N-Myc Downstream-regulated Gene-1 (NDRG1) Expression

Hickok, Jason R.; Sahni, Sumit; Mikhed, Yuliya; Bonini, Marcelo G.; Thomas, Douglas D.

doi:10.1074/jbc.m111.287052

Nitric Oxide Suppresses Tumor Cell Migration through N-Myc Downstream-regulated Gene-1 (NDRG1) Expression

Background: Expression of N-Myc downstream-regulated gene 1 inversely correlates with patient outcome. Results: Nitric oxide exposure leads to NDRG1 gene expression, which inhibits tumor cell migration. Conclusion: Nitric oxide-mediated sequestration of chelatable iron via dinitrosyliron complex …