The Near-iron Transporter (NEAT) Domains of the Anthrax Hemophore IsdX2 Require a Critical Glutamine to Extract Heme from Methemoglobin

Honsa, Erin S.; Owens, Cedric P.; Goulding, Celia W.; Maresso, Anthony W.

doi:10.1074/jbc.m112.430009

The Near-iron Transporter (NEAT) Domains of the Anthrax Hemophore IsdX2 Require a Critical Glutamine to Extract Heme from Methemoglobin

Background: Bacillus anthracis secretes IsdX2 to acquire heme from methemoglobin. Results: Heme extraction occurs when IsdX2 near-iron transporter (NEAT) domains contain a residue with an amide side chain in the fifth position of the 310-helix. Conclusion: An amide side chain is necessary and suf…