Ankyrin-B Regulates Cav2.1 and Cav2.2 Channel Expression and Targeting

Kline, Crystal F.; Scott, John; Curran, Jerry; Hund, Thomas J.; Mohler, Peter J.

doi:10.1074/jbc.m113.523639

Ankyrin-B Regulates Cav2.1 and Cav2.2 Channel Expression and Targeting

Background: Calcium channels control membrane excitability. The mechanisms underlying Cav2.1/Cav2.2 targeting are not well understood. Results: Ankyrin-B associates with Cav2.1/Cav2.2. Loss of ankyrin-B results in reduced expression of Cav2.1/Cav2.2 in select brain regions. Conclusion: Ankyrin-B …