The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Genetic Analysis of the Structure and Function of 7SK Small Nuclear Ribonucleoprotein (snRNP) in Cells
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The GUAC motif has been reported in 7SK small nuclear RNA (7SK) as a part of the 7SK small nuclear ribonucleoprotein (7SK snRNP).”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [74]
In the citing paper
“This motif is required to inactivate the positive transcription elongation factor b in cells by interacting with hexamethylene bisacetamide-induced protein (HEXIM) 1, which is also incorporated in 7SK snRNP [74].”
From Differential RNA packaging into small extracellular vesicles by neurons and astrocytes (2021) · cites this paper as [74]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Defining mechanisms that regulate RNA polymerase II transcription in vivo
Fuda, N. J., Ardehali, M. B., & Lis, J. T. (2009) · Nature · doi:10.1038/nature08449 · Cited by 576
Flagged first, then by citations
Research works printed but not linked: 53
- Shilatifard, 2003, The RNA polymerase II elongation complex, Annu. Rev. Biochem, 72, 693, 10.1146/annurev.biochem.72.121801.161551 · DOI
- Peterlin, 2010, Transcription elongation takes central stage: the P-TEFb connection, Cell Cycle, 9, 2933, 10.4161/cc.9.15.12698 · DOI
- Price, 2008, Poised polymerases: on your mark, get set, go!, Mol. Cell, 30, 7, 10.1016/j.molcel.2008.03.001 · DOI
- Peterlin, 2006, Controlling the elongation phase of transcription with P-TEFb, Mol. Cell, 23, 297, 10.1016/j.molcel.2006.06.014 · DOI · Paper page
- Zhou, 2006, The Yin and Yang of P-TEFb regulation: implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation, Microbiol. Mol. Biol. Rev, 70, 646, 10.1128/MMBR.00011-06 · DOI
- He, 2010, HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription, Mol. Cell, 38, 428, 10.1016/j.molcel.2010.04.013 · DOI
- Sobhian, 2010, HIV-1 Tat assembles a multifunctional transcription elongation complex and stably associates with the 7SK snRNP, Mol. Cell, 38, 439, 10.1016/j.molcel.2010.04.012 · DOI
- Jang, 2005, The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription, Mol. Cell, 19, 523, 10.1016/j.molcel.2005.06.027 · DOI
- Yang, 2005, Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4, Mol. Cell, 19, 535, 10.1016/j.molcel.2005.06.029 · DOI
- He, 2011, New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC), J. Neuroimmune Pharmacol, 6, 260, 10.1007/s11481-011-9267-6 · DOI
- Chen, 2008, PP2B and PP1α cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling, Genes Dev, 22, 1356, 10.1101/gad.1636008 · DOI
- He, 2006, Modulation of a P-TEFb functional equilibrium for the global control of cell growth and differentiation, Mol. Cell Biol, 26, 7068, 10.1128/MCB.00778-06 · DOI
- Bartholomeeusen, 2013, HDAC inhibitors that release positive transcription elongation factor b (P-TEFb) from its inhibitory complex also activate HIV transcription, J. Biol. Chem, 288, 14400, 10.1074/jbc.M113.464834 · DOI
- Bartholomeeusen, 2012, BET bromodomain inhibition activates transcription via a transient release of P-TEFb from 7SK snRNP, J. Biol. Chem, 287, 36609, 10.1074/jbc.M112.410746 · DOI
- Contreras, 2007, HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription, PLoS Pathog, 3, 1459, 10.1371/journal.ppat.0030146 · DOI
- Peterlin, 2012, 7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription, Wiley Interdiscip. Rev. RNA, 3, 92, 10.1002/wrna.106 · DOI
- Barrandon, 2007, The transcription-dependent dissociation of P-TEFb-HEXIM1–7SK RNA relies upon formation of hnRNP-7SK RNA complexes, Mol. Cell Biol, 27, 6996, 10.1128/MCB.00975-07 · DOI
- Krueger, 2008, LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated, Nucleic Acids Res, 36, 2219, 10.1093/nar/gkn061 · DOI
- Marz, 2009, Evolution of 7SK RNA and its protein partners in metazoa, Mol. Biol. Evol, 26, 2821, 10.1093/molbev/msp198 · DOI
- Muniz, 2010, Controlling cellular P-TEFb activity by the HIV-1 transcriptional transactivator Tat, PLoS Pathog, 6, e1001152, 10.1371/journal.ppat.1001152 · DOI
- Barboric, 2007, Tat competes with HEXIM1 to increase the active pool of P-TEFb for HIV-1 transcription, Nucleic Acids Res, 35, 2003, 10.1093/nar/gkm063 · DOI
- Sedore, 2007, Manipulation of P-TEFb control machinery by HIV: recruitment of P-TEFb from the large form by Tat and binding of HEXIM1 to TAR, Nucleic Acids Res, 35, 4347, 10.1093/nar/gkm443 · DOI
- Muniz, 2013, RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP, Nucleic Acids Res, 41, 4686, 10.1093/nar/gkt159 · DOI
- Yik, 2003, Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA, Mol. Cell, 12, 971, 10.1016/S1097-2765(03)00388-5 · DOI
- Michels, 2003, MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner, Mol. Cell Biol, 23, 4859, 10.1128/MCB.23.14.4859-4869.2003 · DOI
- Yik, 2004, A human immunodeficiency virus type 1 Tat-like arginine-rich RNA-binding domain is essential for HEXIM1 to inhibit RNA polymerase II transcription through 7SK snRNA-mediated inactivation of P-TEFb, Mol. Cell Biol, 24, 5094, 10.1128/MCB.24.12.5094-5105.2004 · DOI
- Li, 2007, HEXIM1 is a promiscuous double-stranded RNA-binding protein and interacts with RNAs in addition to 7SK in cultured cells, Nucleic Acids Res, 35, 2503, 10.1093/nar/gkm150 · DOI
- Michels, 2004, Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor, EMBO J, 23, 2608, 10.1038/sj.emboj.7600275 · DOI
- Li, 2005, Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186, J. Biol. Chem, 280, 28819, 10.1074/jbc.M502712200 · DOI
- Barboric, 2005, Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb, EMBO J, 24, 4291, 10.1038/sj.emboj.7600883 · DOI
- Blazek, 2005, Oligomerization of HEXIM1 via 7SK snRNA and coiled-coil region directs the inhibition of P-TEFb, Nucleic Acids Res, 33, 7000, 10.1093/nar/gki997 · DOI
- Bigalke, 2011, Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1, J. Mol. Biol, 414, 639, 10.1016/j.jmb.2011.10.022 · DOI
- Tiley, 1992, The VP16 transcription activation domain is functional when targeted to a promoter-proximal RNA sequence, Genes Dev, 6, 2077, 10.1101/gad.6.11.2077 · DOI
- Bieniasz, 1999, Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription, Proc. Natl. Acad. Sci. U.S.A, 96, 7791, 10.1073/pnas.96.14.7791 · DOI
- Fujinaga, 1998, The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat, J. Virol, 72, 7154, 10.1128/JVI.72.9.7154-7159.1998 · DOI
- Fujinaga, 1999, Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T, Proc. Natl. Acad. Sci. U.S.A, 96, 1285, 10.1073/pnas.96.4.1285 · DOI
- Lu, 1993, The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat, J. Virol, 67, 1752, 10.1128/jvi.67.4.1752-1760.1993 · DOI
- Fujinaga, 2002, Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression, J. Virol, 76, 10873, 10.1128/JVI.76.21.10873-10881.2002 · DOI
- Wassarman, 1991, Structural analyses of the 7SK ribonucleoprotein (RNP), the most abundant human small RNP of unknown function, Mol. Cell Biol, 11, 3432
- Bélanger, 2009, U30 of 7SK RNA forms a specific photo-cross-link with Hexim1 in the context of both a minimal RNA-binding site and a fully reconstituted 7SK/Hexim1/P-TEFb ribonucleoprotein complex, J. Mol. Biol, 386, 1094, 10.1016/j.jmb.2009.01.015 · DOI
- Egloff, 2006, Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding, Mol. Cell Biol, 26, 630, 10.1128/MCB.26.2.630-642.2006 · DOI
- Lebars, 2010, HEXIM1 targets a repeated GAUC motif in the riboregulator of transcription 7SK and promotes base pair rearrangements, Nucleic Acids Res, 38, 7749, 10.1093/nar/gkq660 · DOI
- Barboric, 2001, NF-κB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II, Mol. Cell, 8, 327, 10.1016/S1097-2765(01)00314-8 · DOI
- Southgate, 1990, Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein, Nature, 345, 640, 10.1038/345640a0 · DOI
- Wei, 1998, A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA, Cell, 92, 451, 10.1016/S0092-8674(00)80939-3 · DOI
- Richter, 2002, Specific HIV-1 TAR RNA loop sequence and functional groups are required for human cyclin T1-Tat-TAR ternary complex formation, Biochemistry, 41, 6391, 10.1021/bi0159579 · DOI · Paper page
- Richter, 2002, TAR RNA loop: a scaffold for the assembly of a regulatory switch in HIV replication, Proc. Natl. Acad. Sci. U.S.A, 99, 7928, 10.1073/pnas.122119999 · DOI
- Byers, 2005, HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK, J. Biol. Chem, 280, 16360, 10.1074/jbc.M500424200 · DOI
- Selby, 1989, Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeat, Genes Dev, 3, 547, 10.1101/gad.3.4.547 · DOI
- Kwak, 2013, Precise maps of RNA polymerase reveal how promoters direct initiation and pausing, Science, 339, 950, 10.1126/science.1229386 · DOI · Paper page
- Ji, 2013, SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase, Cell, 153, 855, 10.1016/j.cell.2013.04.028 · DOI
- McNamara, 2013, Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation, Cell Rep, 5, 1256, 10.1016/j.celrep.2013.11.003 · DOI
- Fujinaga, 2012, PKC phosphorylates HEXIM1 and regulates P-TEFb activity, Nucleic Acids Res, 40, 9160, 10.1093/nar/gks682 · DOI
Cited by
Sorted by citations
Differential RNA packaging into small extracellular vesicles by neurons and astrocytes
Luo, X., Jean-Toussaint, R., Sacan, A., & Ajit, S. K. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00757-4 · Cited by 32
Metadata
- Authors
- Fujinaga, K., Luo, Z., & Peterlin, B. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 289
- Issue
- 30
- Pages
- 21181-21190
- ISSN
- 0021-9258
- Cited by
- 20
- References
- 1
- Language
- en
- Licence
- Funders
- National Institutes of Health (U19 AI076113)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review