Wnt/β-Catenin Signaling Mediates Osteoblast Differentiation Triggered by Peptide-induced α5β1 Integrin Priming in Mesenchymal Skeletal Cells

Saidak, Zuzana; Le Henaff, Carole; Azzi, Sofia; Marty, Caroline; Da Nascimento, Sophie; Sonnet, Pascal; Marie, Pierre J.

doi:10.1074/jbc.m114.621219

Wnt/β-Catenin Signaling Mediates Osteoblast Differentiation Triggered by Peptide-induced α5β1 Integrin Priming in Mesenchymal Skeletal Cells

Background: The mechanisms whereby α5β1 integrin triggers osteogenesis are poorly understood. Results: CRRETAWAC-mediated α5β1 integrin priming promotes osteoblast differentiation via PI3K/Wnt/β-catenin signaling independently of the RGD-like REET sequence. Systemic delivery of the α5β1 integrin-…