No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

Fleury, C., Neverova, M., Collins, S., Raimbault, S., Champigny, O., Lévi-Meyrueis, C., Bouillaud, F., Seldin, M. F., Surwit, R. S., Ricquier, D., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-269 · Cited by 1,630

Superoxide activates mitochondrial uncoupling proteins

Echtay, K. S., Roussel, D., St-Pierre, J., Jekabsons, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., et al. (2002) · Nature · doi:10.1038/415096a · Cited by 1,382

Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

Enerbäck, S., Jacobsson, A., Simpson, E. M., Guerra, C., Yamashita, H., Harper, M.-E., & Kozak, L. P. (1997) · Nature · doi:10.1038/387090a0 · Cited by 1,379

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves‐Guerra, M., Goubern, M., Surwit, R. S., et al. (2000) · Nature Genetics · doi:10.1038/82565 · Cited by 1,100

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917

Uncoupling: new approaches to an old problem of bioenergetics

Skulachev, V. P. (1998) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(97)00091-1 · Cited by 893

Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids

Racker, E. (1950) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(50)90026-6 · Cited by 814

The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

Ricquier, D., & Bouillaud, F. (2000) · Biochemical Journal · doi:10.1042/bj3450161 · Cited by 811

A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

Nègre‐Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayre, R., Pénicaud, L., & Casteilla, L. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.10.9271366 · Cited by 773

Energy metabolism in uncoupling protein 3 gene knockout mice

Vidal-Puig, A. J., Grujic, D., Zhang, C.-Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910179199 · Cited by 677

FM19G11 Favors Spinal Cord Injury Regeneration and Stem Cell Self-Renewal by Mitochondrial Uncoupling and Glucose Metabolism Induction

Rodríguez-Jiménez, F. J., Alastrue‐Agudo, A., Erceg, S., Stojković, M., & Moreno‐Manzano, V. (2012) · Stem Cells · doi:10.1002/stem.1189 · Cited by 36

Antioxidant and Regulatory Role of Mitochondrial Uncoupling Protein UCP2 in Pancreatic β-cells

Ježek, P., Olejár, T., Smolková, K., Ježek, J., Dlasková, A., Plecitá‐Hlavatá, L., Zelenka, J., Špaček, T., Engstová, H., Reguera, D. P., et al. (2014) · Physiological Research · doi:10.33549/physiolres.932633 · Cited by 38

Uncoupling Protein 2, but Not Uncoupling Protein 1, Is Expressed in the Female Mouse Reproductive Tract

Rousset, S., Alves‐Guerra, M., Ouadghiri-Bencherif, S., Kozak, L. P., Miroux, B., Richard, D., Bouillaud, F., Ricquier, D., & Cassard, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306980200 · Cited by 34

Uncoupling protein 2 and 3 in marsupials: identification, phylogeny, and gene expression in response to cold and fasting in Antechinus flavipes

Jastroch, M., Withers, K., & Klingenspor, M. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00165.2003 · Cited by 35

Alteration of Plant Mitochondrial Proton Conductance by Free Fatty Acids

Cabassa, C., Mesneau, A., Miroux, B., Roussaux, J., Ricquier, D., Zachowski, A., & Moreau, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202805200 · Cited by 34

Role of UCP2 and UCP3 in nutrition and obesity

Nagy, T. R., Blaylock, M. L., & Garvey, W. T. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.024 · Cited by 35

Uncoupling proteins: Martin Klingenberg's contributions for 40 years

Echtay, K. S., Bienengraeber, M., Mayinger, P., Heimpel, S., Winkler, E., Druhmann, D., Frischmuth, K., Kamp, F., & Huang, S. (2018) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2018.09.006 · Cited by 31

Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1)

Nishio, K., Qiao, S., & Yamashita, H. (2005) · The Histochemical Journal · doi:10.1007/s10735-004-2915-x · Cited by 29

Mitochondrial uncoupling protein 2 in pancreatic β ‐cells

Brand, M. D., Parker, N., Affourtit, C., Mookerjee, S. A., & Azzu, V. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01264.x · Cited by 29

Molecular evolution of uncoupling proteins and implications for brain function

Gaudry, M. J., & Jastroch, M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.12.027 · Cited by 28

Alleviation of fatty acid and hypoxia-reoxygenation-induced proximal tubule deenergization by ADP/ATP carrier inhibition and glutamate

Feldkamp, T., Kribben, A., Roeser, N. F., Ostrowski, T., & Weinberg, J. M. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00476.2006 · Cited by 27

Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice

Wang, Q., Wang, J., Hu, M., Yu, Y. W., Guo, L., Xu, J., Lei, C., Jiao, Y., & Xu, J. (2016) · Mediators of Inflammation · doi:10.1155/2016/9154230 · Cited by 28

Deletion of Uncoupling Protein‐2 reduces renal mitochondrial leak respiration, intrarenal hypoxia and proteinuria in a mouse model of type 1 diabetes

Friederich‐Persson, M., Persson, P., Hansell, P., & Palm, F. (2018) · Acta Physiologica · doi:10.1111/apha.13058 · Cited by 26

The contribution of uncoupling protein 2 to mitochondrial Ca2+ homeostasis in health and disease – A short revisit

Koshenov, Z., Oflaz, F. E., Hirtl, M., Bachkoenig, O. A., Rost, R., Osibow, K., Gottschalk, B., Madreiter‐Sokolowski, C. T., Waldeck‐Weiermair, M., Malli, R., et al. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.10.003 · Cited by 24

Inhibition of high glucose-induced apoptosis by uncoupling protein 2 in human umbilical vein endothelial cells

He, Y., Wang, N., Shen, Y., Zheng, Z. J., & Xu, X. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.1676 · Cited by 24

Development of Chromanes as Novel Inhibitors of the Uncoupling Proteins

Rial, E., Rodríguez-Sánchez, L., Aller, P., Guisado, A., González‐Barroso, M. M., Gallardo‐Vara, E., Redondo‐Horcajo, M., Castellanos, E., de la Pradilla, R. F., & Viso, A. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.12.012 · Cited by 24

Oxidative phosphorylation, mitochondrial proton cycling, free-radical production and aging

Speakman, J. R. (2003) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(03)14003-5 · Cited by 25

Uncoupling protein‐3 sensitizes cells to mitochondrial‐dependent stimulus of apoptosis

Dejean, L. M., Cámara, Y., Sibille, B., Solanes, G., & Villarroya, F. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20048 · Cited by 25

Apelin-13 protects the lungs from ischemia-reperfusion injury by attenuating inflammatory and oxidative stress

Xia, F., Chen, H., Jin, Z., & Fu, Z. (2020) · Human & Experimental Toxicology · doi:10.1177/0960327120961436 · Cited by 22

The role of uncoupling protein 2 in macrophages and its impact on obesity-induced adipose tissue inflammation and insulin resistance

van Dierendonck, X. A. M. H., Sancerni, T., Alves‐Guerra, M., & Stienstra, R. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014868 · Cited by 21

Recruitment of mitochondrial uncoupling protein UCP2 after lipopolysaccharide induction

Růžička, M., Škobisová, E., Dlasková, A., Šantorová, J., Smolková, K., Špaček, T., Žáčková, M., Modrianský, M., & Ježek, P. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.016 · Cited by 22

Mitochondrial ion channels in pancreatic β‐cells: Novel pharmacological targets for the treatment of Type 2 diabetes

Marchi, U. D., Fernandez‐Martinez, S., de la Fuente, S., Wiederkehr, A., & Domingo, J. S. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15018 · Cited by 22

Fatty acids do not activate UCP2 in pancreatic beta cells: comparison with UCP1

Galetti, S., Sarre, A., Perreten, H., Produit-Zengaffinen, N., Muzzin, P., & Assimacopoulos‐Jeannet, F. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0548-8 · Cited by 19

Role of UCP2 in the Energy Metabolism of the Cancer Cell Line A549

Segalés, J., Sànchez‐Martìn, C., Pujol-Morcillo, A., Martín‐Ruíz, M., Santos, P. D. L., Lobato-Alonso, D., Oliver, E., & Rial, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098123 · Cited by 17

Kainic acid upregulates uncoupling protein-2 mRNA expression in the mouse brain

Clavel, S., Paradis, É., Ricquier, D., & Richard, D. (2003) · Neuroreport · doi:10.1097/00001756-200311140-00002 · Cited by 18

Deletion of UCP2 in iNOS Deficient Mice Reduces the Severity of the Disease during Experimental Autoimmune Encephalomyelitis

Aheng, C., Ly, N. Y., Kelly, M., Ibrahim, S. M., Ricquier, D., Alves‐Guerra, M., & Miroux, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022841 · Cited by 16

UCP-2 is involved in angiotensin-II-induced abdominal aortic aneurysm in apolipoprotein E-knockout mice

Yan, P., Chen, K., Wang, Q., Yang, D., Li, D., & Yang, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0179743 · Cited by 15

Protein-mediated energy-dissipating pathways in mitochondria

Starkov, A. A. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.02.009 · Cited by 14

ATP Accelerates Respiration of Mitochondria From Rat Lung and Suppresses Their Release of Hydrogen Peroxide

Carlson, D. E., Pumplin, D. W., Ghavam, S., Fiedler, S. M., Chiu, W. C., & Scalea, T. M. (2005) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-005-8644-3 · Cited by 14

UCP2 and pancreatic cancer: conscious uncoupling for therapeutic effect

Caggiano, E. G., & Taniguchi, C. M. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-023-10157-4 · Cited by 13

Molecular Properties of Purified Human Uncoupling Protein 2 Refolded from Bacterial Inclusion Bodies

Jekabsons, M. B., Echtay, K. S., Aréchaga, I., & Brand, M. D. (2003) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1027335713635 · Cited by 10

Assessment of a high-throughput screening methodology for the measurement of purified UCP1 uncoupling activity

Mozo, J., Ferry, G., Masscheleyn, S., Miroux, B., Boutin, J. A., & Bouillaud, F. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.01.033 · Cited by 11

Treadmill exercise with nanoselenium supplementation affects the expression of Irisin/FNDC5 and semaphorin 3A in rats exposed to cigarette smoke extract

Arabzadeh, E., Shirvani, H., Masjedi, M. R., Ghanei, M., Hofmeister, M., & Rostamkhani, F. (2023) · 3 Biotech · doi:10.1007/s13205-023-03849-9 · Cited by 9

Molecular evolution of thermogenic uncoupling protein 1 and implications for medical intervention of human disease

Gaudry, M. J., Keuper, M., & Jastroch, M. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.006 · Cited by 9

Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung

Yakubu, D. P., Mostyn, A., Hyatt, M. A., Kurlak, L. O., Budge, H., Stephenson, T. J., & Symonds, M. E. (2007) · Reproduction · doi:10.1530/rep-07-0155 · Cited by 8

Mitochondrial ATP Synthase and Mild Uncoupling by Butyl Ester of Rhodamine 19, C4R1

Zorova, L. D., Pevzner, I. B., Khailova, L. S., Korshunova, G. A., Ковалева, М. А., Ковалев, Л. И., Serebryakova, M. V., Silachev, D. N., Sudakov, R. V., Zorov, S. D., et al. (2023) · Antioxidants · doi:10.3390/antiox12030646 · Cited by 7

Hydroxynonenal, a lipid peroxidation end product, stimulates uncoupling protein activity in Acanthamoeba castellanii mitochondria; the sensitivity of the inducible activity to purine nucleotides depends on the membranous ubiquinone redox state

Woyda-Ploszczyca, A. M., & Jarmuszkiewicz, W. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9456-x · Cited by 7

Chronic Alcohol Consumption Increases the Expression of Uncoupling Protein‐2 and ‐4 in the Brain

Graw, J. A., von Haefen, C., Poyraz, D., Möbius, N., Sifringer, M., & Spies, C. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12144 · Cited by 7

Metabolic Reprogramming in Cancer and Metabolic Theory of CSC

Pavlović, M. D., & Radotić, K. (2017) · Springer eBooks · doi:10.1007/978-3-319-47763-3_11 · Cited by 3

Mice overexpressing chromogranin A display hypergranulogenic adrenal glands with attenuated ATP levels contributing to the hypertensive phenotype

Mir, S. A., Li, Y., Story, J. D., Bal, S., Awdishu, L., Street, A. A., Mehta, R. L., Singh, P., & Vaingankar, S. M. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001678 · Cited by 3

Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins

Porter, R. K. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_7 · Cited by 3

Inter‐Caste Comparison Reveals a Unique Bioenergetic Signature in Long‐Lived Ant Queens

Kervella, M., Bertile, F., Granger‐Farbos, A., Pinson, B., Villette, C., Heintz, D., Schmitt, A., Quque, M., Bouillaud, F., & Criscuolo, F. (2025) · Molecular Ecology · doi:10.1111/mec.70127 · Cited by 1

Thyroid Hormone and Myocardial Mitochondria

Marín-García, J. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4599-9_22 · Cited by 2

Uncoupling proteins UCP2 and UCP3 from mitochondria of liver and skeletal muscle of ground squirrel Spermophilus undulatus do not transport pyruvate in contrast to UCP1 from brown adipose tissue

Komelina, N. P., & Amerkhanov, Z. G. (2014) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747813050073 · Cited by 1

On obesity in acute pancreatitis

Segersvärd, R. (2005) · Figshare · Cited by 1

Papel de la proteína desacoplante UCP2 en el estrés oxidativo provocado por la metformina en el adipocito blanco

Anedda, A. (2010) · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)

5.4 Uncoupling Proteins

Kim‐Han, J. S., Ali, S. S., & Dugan, L. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-30411-3_20

Regulation of Fatty Acid Transport Across the Mitochondrial Membranes in Human and Rodent Skeletal Muscle

Bézaire, V. (2005) · Canadian Journal of Applied Physiology · doi:10.1139/h05-145

The pathophysiology of respiratory chain dysfunction

Silva, J. P. (2005) · Figshare

LeakRegulation and Physiology of Mitochondrial Proton

Dalton, N. D., Peterson, K. L., Gu, Y., Matkovich, S. J., Murphy, A. N., Ling, H., Divakaruni, A. S., Zambon, A. C., King, M. S., Kunji, E. R. S., et al. (2015)

Tesi doctoral presentada per En/Na

Ironia, E. I. (2002)

Estudio comparativo de los efectos producidos por la hipoxia crónica intermitente en ratas jóvenes (3 meses) y viejas (24 meses)

Coca, M. Q. (2015) · doi:10.35376/10324/16658

Mitochondrial Respiration of Cancer Stem Cell

Pavlović, M. D., & Balint, B. (2015) · Springer eBooks · doi:10.1007/978-3-319-25670-2_7

Dieta hipercalórica e hipoxia intermitente crónica como modelos de obesidad y apnea obstructiva del sueño. Significado de la leptina en el control respiratorio

Fraile, E. O. (2016) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/20828

Efectos inducidos por la hipoxia crónica intermitente en rata y cobaya como modelos animales de la apnea obstructiva del sueño

Docio, I. (2019) · UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) · doi:10.35376/10324/35124

Fuelling the fire : Immunometabolism of monocytes and macrophages in obesity & diabetes

van Dierendonck, X. A. M. H. (2021) · doi:10.18174/545884

Quel est le rôle des protéines découplantes mitochondriales chez les mammifères et les oiseaux ?

DAMON, M., & Collin, A. (2006) · INRAE Productions Animales · doi:10.20870/productions-animales.2006.19.4.3497 · Cited by 3

THE CHARACTERISTIC MITOCHONDRIAL OXIDATIONS OF A SPLEEN OF RATS

Абдулкадер, А. (2007) · Health and Ecology Issues · doi:10.51523/2708-6011.2007-4-4-16

Mitochondrial Dysfunction: Potential Therapy For Abdominal Aortic Aneurysms

Yang, W., He, J., Yu, H., Wu, Y., & Shi, S. (2025) · Current Vascular Pharmacology · doi:10.2174/0115701611312293241220101556 · Cited by 2

Pro‐ and Anti‐Inflammatory Macrophages Adjust UCP2 Protein Levels Based on Their Intrinsic Metabolism and Available Metabolites

Nasirzade, J., Sternberg, F., Vogel, A., Sango, R., Beikbaghban, T., Kolbe, T., Rattei, T., Weichhart, T., & Pohl, E. E. (2026) · European Journal of Immunology · doi:10.1002/eji.70218

Impact de la perte du transporteur mitochondrial UCP2 sur la physiologie de l'intestin et l'immunité favorisant la tumorigenèse colorectale

Luby, A. (2024) · theses.fr (ABES) · doi:10.70675/8759af0czcd7cz459az8396z5ab690fd4aa1

Uncoupling Protein 2 and Nitric Oxide Deficiency Favor Glycolytic Pathways and Organ Growth in the Rat Spleen

Wagner, L., Schreckenberg, R., Itani, N., Sato, T., Sperhake, J., Cesar, Y., & Schlüter, K. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48080775

A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2

Krauss, S., Zhang, C., & Lowell, B. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012410699 · Cited by 176

Uncoupling protein 2 in regulatory mechanisms and basical experiments

Chen, Y. (2016) · International journal of pediatrics · doi:10.3760/cma.j.issn.1673-4408.2016.09.010

Antioxidant activity by a synergy of redox-sensitive mitochondrial phospholipase A2 and uncoupling protein-2 in lung and spleen

Jabůrek, M., Ježek, J., Zelenka, J., & Ježek, P. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.01.010 · Cited by 44

Cytoprotective activity of mitochondrial uncoupling protein‐2 in lung and spleen

Jabůrek, M., Ježek, J., & Ježek, P. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12410 · Cited by 6

Physiological Levels of Mammalian Uncoupling Protein 2 Do Not Uncouple Yeast Mitochondria*

Brand, M. D. (2015)