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Yeast Cox11, a Protein Essential for Cytochrome cOxidase Assembly, Is a Cu(I)-binding Protein
Open accessAbstract
Cox11 is a protein essential for respiratory growth and has been implicated in the assembly of the Cu(B) site of cytochrome c oxidase. In the present study, we demonstrate that Cox11 is a copper-binding protein. The soluble C-terminal domain of Cox11 forms a dimer that coordinates one Cu(I) per monomer via three thiolate ligands. The two Cu(I) ions in the dimer exist in a binuclear cluster and appear to be ligated by three conserved Cys residues. Mutation of any of these Cys residues reduces Cu(I) binding and confers respiratory incompetence. Cytochrome c oxidase activity is reduced in these mutants. Thus, the residues important for Cu(I) binding correlate with in vivo function, suggesting that Cu(I) binding is important in Cox11 function.
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Citations
Cited by
Gaggelli, E., Kozlowski, H., Valensin, D., & Valensin, G. (2006) · Chemical Reviews · doi:10.1021/cr040410w · Cited by 1,729
Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors
Finney, L. A., & O'Halloran, T. V. (2003) · Science · doi:10.1126/science.1085049 · Cited by 1,100
Copper trafficking to the mitochondrion and assembly of copper metalloenzymes
Cobine, P. A., Pierrel, F., & Winge, D. R. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.03.002 · Cited by 317
Self-citationMitochondrial copper metabolism and delivery to cytochrome c oxidase
Horn, D., & Barrientos, A. (2008) · IUBMB Life · doi:10.1002/iub.50 · Cited by 283
Cu Homeostasis in Bacteria: The Ins and Outs
Andrei, A., Öztürk, Y., Khalfaoui-Hassani, B., Rauch, J., Marckmann, D., Trasnea, P.-I., Daldal, F., & Koch, H.-G. (2020) · Membranes · doi:10.3390/membranes10090242 · Cited by 153
Metadata
- Authors
- Carr, H. S., George, G. N., & Winge, D. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 277
- Issue
- 34
- Pages
- 31237-31242
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2039168627
- Cited by
- 171
- References
- 0
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Carr, H. S., George, G. N., & Winge, D. R. (2002). Yeast Cox11, a Protein Essential for Cytochrome cOxidase Assembly, Is a Cu(I)-binding Protein. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m204854200
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