A Novel Host-Parasite Lipid Cross-talk
Open accessAbstract
Schistosome infections are characterized by prominent T cell hyporesponsiveness during the chronic stage of infection. We found that schistosome-specific phosphatidylserine (PS) activated TLR2 and affected dendritic cells such that mature dendritic cells gained the ability to induce the development of IL-10-producing regulatory T cells. Using mass spectrometry, schistosomal lysophosphatidylserine (lyso-PS) was identified as the TLR2-activating molecule. This activity appears to be a unique property of schistosomal lyso-PS, containing specific acyl chains, because neither a synthetic lyso-PS (16:0) nor PS isolated from the mammalian host activates TLR2. Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology.
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LysoPS is a TLR2 ligand that increases the capacity of human DCs to drive IL-10-producing T cells, suppressing T cell proliferation.
“LysoPS is a TLR2 ligand that increases the capacity of human DCs to drive IL-10-producing T cells, suppressing T cell proliferation”
From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as van der Kleij et al., 2002
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References 48 · Cited by 587
- Authors
- van der Kleij, D., Latz, E., Brouwers, J. F. H. M., Kruize, Y. C. M., Schmitz, M., Kurt-Jones, E. A., Espevik, T., de Jong, E. C., Kapsenberg, M. L., Golenbock, D. T., Tielens, A. G. M., & Yazdanbakhsh, M.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Norwegian University of Science and Technology (NO)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Yazdanbakhsh, Maria
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-12
- Volume
- 277
- Issue
- 50
- Pages
- 48122-48129
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2065927080
- Cited by
- 587
- References
- 48
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 10 · 2022: 17 · 2021: 11 · 2020: 24 · 2019: 18 · 2018: 18 · 2017: 14 · 2016: 20 · 2015: 19 · 2014: 26 · 2013: 22 · 2012: 30
- FWCI
- 31.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Funders
- Deutscher Akademischer Austauschdienst
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- schistosomiasis, TLR2, phosphatidylserine, lysophosphatidylserine, dendritic cells, regulatory T cells, IL-10, T cell hyporesponsiveness, host-parasite interactions, parasite survival
- MeSH terms
- Animals, Base Sequence, Cell Line, Host-Parasite Interactions, Humans, Lysophospholipids, Membrane Glycoproteins, Oligodeoxyribonucleotides, Receptors, Cell Surface, Schistosoma mansoni, T-Lymphocytes, Drosophila Proteins, Toll-Like Receptors, Toll-Like Receptor 2
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